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İntramukozal Karsinomun Eşlik Ettiği Duodenum Villöz Adenomu

Year 2020, Volume: 3 Issue: 2, 99 - 102, 01.07.2020

Abstract

İnce bağırsak primer tümörleri nadir görülür. Villöz ve tübülovillöz duodenum adenomların
görülme sıkılığı gastrointestinal şikâyetleri olan ve polipozis sendromlu olan hastalarda
tarama muayenesi için üst gastrointestinal endoskopi kullanımının yaygınlaşması nedeniyle
artış göstermiştir. Villöz duodenum adenomları, benign periampüller neoplazmlar arasında
en yaygınlarıdır ve malignant dönüşüm oranı %30-60 arasında değişen premalign lezyonlar
olarak kabul edilirler. Genellikle ampulla vateri yakınlarında olan konumları nedeniyle kanama,
safra yolu tıkanıklığı, pankreatit, duodenal tıkanıklık ile karakterize edilen semptomlara
neden olurlar. İnvaziv kanserlerde seçilen prosedür, pankreatikoduodenektomidir. Benign
olan ya da karsinoma in situ içeren bu lezyonlarda uygun tedavi tartışılmaktadır. Bu vakada
69 yaşında, beyin ameliyatı sonrası gelişen yutkunma bozukluğu nedeniyle yapılan perkütan
endoskopik gastrostomi esnasında lezyon tespit edilen bir hastanın sunumunu yapılacaktır.
Endoskopik biyopsi ve ameliyat sonrası patolojik sonuç lezyonuın iyi diferansiye intramukozal
adenokarsinom olduğunu göstermiştir.

References

  • 1. Sakorafas GH, Friess H, Dervenis CG. Villous Tumors of the duodenum: Biologic characters and clinical implications. Scand J Gastroenterol. 2000; 35: 337-344.
  • 2. Galandiuk S, Hermann RE, Jagelman DG, Fazio VW, Sivak MV. Villous tumors of the duodenum. Ann Surg. 1988; 207:234-239.
  • 3. Chappuis CW, Divincenti FC, Cohn I Jr. Villous tumors of the duodenum. Ann Surg. 2009; 593–599.
  • 4. Sabahattin A, Bahadır Ç, Fatma Markoç AÇ A duodenal villous adenoma associated with in situ carcinoma: A case report. Turk J Cancer. 2001; 31:162-167.
  • 5. Ryan DP, Schapiro RH, Warshaw AL. Villous tumors of the duodenum. Ann Surg. 1986; 203(3):301-306.
  • 6. Komorowski ZH, Cohen EB. Villous tumors of the duodenum: a clinico-pathological study. Cancer. 1981; 15;47(6):1377–1386.
  • 7. Pezet D, Rotman N, Slim K, Boudet MJ, Chipponi J, Fagniez PL Villous tumors of the duodenum: a retrospective study of 47 cases by the French Association of Surgical Research. J Am Coll Surg. 1995; 180(5):541-544.
  • 8. Cahen DL, Fockens P, De Wit LT, Offerhaus GJ, Obertop H, Gouma DJ. Local resection or pancreaticoduodenectomy for villous adenoma of the ampulla of Vater diagnosed before operation. Br J Surg. 1997; 84(7):948-951.
  • 9. McFarlane ME. Villous tumor of the duodenum: report of a case and review of the literature. J Hepatobiliary Pancreat Surg. 2001; 8(1):107-109.
  • 10. Kutin ND, Ranson JH, Gouge TH, Localio SA. Villous Tumors of the Duodenum. Ann Surg. 1975; 181(2):164-168.
  • 11. Farnell MB, Sakorafas GH, Sarr MG, Rowland CM, Tsiotos GG, Farley DR, Nagorney DM.Villous Tumors of the Duodenum: Reappraisal of Local vs. Extended Resection. J Gastrointest Surg. 2000; 4(1):13-21.

A Duodenal Villous Adenoma Associated with Intramucosal Carcinoma

Year 2020, Volume: 3 Issue: 2, 99 - 102, 01.07.2020

Abstract

Primary tumors of the small intestine are uncommon. There is an increase in the frequency
of villous and tubulovillous adenomas of the duodenum. This is likely to be caused by an
increase in application of endoscopic examination for evaluating gastrointestinal complaints
and for screening examination of patients with polyposis syndromes. Most frequently seen
benign periampullary neoplasm is duodenum villous adenomas. As they have a 30-60% rate of
malignant transformation, they are as considered to be premalignant lesions. They are usually
located near the ampulla of Vater and cause symptoms such as biliary obstruction, pancreatitis,
bleeding, duodenal obstruction. Pancreaticoduodenectomy remains the procedure of choice with
invasive cancer. The appropriate treatment for those lesions that are benign or contain carcinoma
in situ remains controversial. In these case we report a 69-year old woman, that the lesion is seen
incidentaly while placing a percutaneous endoscopic gastrostomy due to swallowing disorder
after cerebral operation. An endoscopic biopsy and pathological workup after local excision
revealed high diferantiated intramucosal adenocarcinoma.

References

  • 1. Sakorafas GH, Friess H, Dervenis CG. Villous Tumors of the duodenum: Biologic characters and clinical implications. Scand J Gastroenterol. 2000; 35: 337-344.
  • 2. Galandiuk S, Hermann RE, Jagelman DG, Fazio VW, Sivak MV. Villous tumors of the duodenum. Ann Surg. 1988; 207:234-239.
  • 3. Chappuis CW, Divincenti FC, Cohn I Jr. Villous tumors of the duodenum. Ann Surg. 2009; 593–599.
  • 4. Sabahattin A, Bahadır Ç, Fatma Markoç AÇ A duodenal villous adenoma associated with in situ carcinoma: A case report. Turk J Cancer. 2001; 31:162-167.
  • 5. Ryan DP, Schapiro RH, Warshaw AL. Villous tumors of the duodenum. Ann Surg. 1986; 203(3):301-306.
  • 6. Komorowski ZH, Cohen EB. Villous tumors of the duodenum: a clinico-pathological study. Cancer. 1981; 15;47(6):1377–1386.
  • 7. Pezet D, Rotman N, Slim K, Boudet MJ, Chipponi J, Fagniez PL Villous tumors of the duodenum: a retrospective study of 47 cases by the French Association of Surgical Research. J Am Coll Surg. 1995; 180(5):541-544.
  • 8. Cahen DL, Fockens P, De Wit LT, Offerhaus GJ, Obertop H, Gouma DJ. Local resection or pancreaticoduodenectomy for villous adenoma of the ampulla of Vater diagnosed before operation. Br J Surg. 1997; 84(7):948-951.
  • 9. McFarlane ME. Villous tumor of the duodenum: report of a case and review of the literature. J Hepatobiliary Pancreat Surg. 2001; 8(1):107-109.
  • 10. Kutin ND, Ranson JH, Gouge TH, Localio SA. Villous Tumors of the Duodenum. Ann Surg. 1975; 181(2):164-168.
  • 11. Farnell MB, Sakorafas GH, Sarr MG, Rowland CM, Tsiotos GG, Farley DR, Nagorney DM.Villous Tumors of the Duodenum: Reappraisal of Local vs. Extended Resection. J Gastrointest Surg. 2000; 4(1):13-21.
There are 11 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case study
Authors

Asiye Perek This is me

Sefa Ergun This is me 0000-0002-0315-8044

Ali Vedat Durgun This is me

Publication Date July 1, 2020
Acceptance Date June 20, 2020
Published in Issue Year 2020 Volume: 3 Issue: 2

Cite

APA Perek, A., Ergun, S., & Durgun, A. V. (2020). A Duodenal Villous Adenoma Associated with Intramucosal Carcinoma. Tıp Fakültesi Klinikleri Dergisi, 3(2), 99-102.


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