Abstract
Şizofreni, bipolar bozukluk, madde kullanım bozukluğu, majör depresif bozukluk ve anksiyete bozukluğu gibi psikiyatrik bozuklukların tedavisinde kullanılan olanzapine ödeme yol açabilir. Bu yazıda, olanzapin kullanımıyla ilişkilendirilen bir periorbital ödem olgusu ele alındı. Bipolar bozukluk ve çoklu madde kullanım bozukluğu eş tanılarıyla olanzapin 10 mg/gün başlanan 26 yaşındaki erkek hastada tedavinin 9’uncu gününde periorbital ödem ortaya çıktı. Mevcut yan etki olanzapin kullanımı ile ilişkilendirildi ve ilaç kesildi. Olanzapin kesilmesinin 6’ncı gününde periorbital ödem tamamen ortadan kalktı. Hastanın psikiyatrik tanılarıyla ilişkili tedavisi tamamlandı. Takiplerinde ödem gözlenmedi. Sonuç olarak, olanzapin kullanımına bağlı olarak periorbital ödem görülebileceği unutulmamalıdır.
Keywords
References
- Callaghan JT, Bergstrom RF, Ptak LR, et al. Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 1999;37(3):177-193.
- Gıynaş-Ayhan M, Dağıstan AA, Yılmaz G, et al. Periorbital edema induced by olanzapine: a case report. Anatolian Journal of Psychiatry 2017;18(1):56-58.
- American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.).
- Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of naranjo adverse drug reactions probability scale. Psychiatry Clin Psychopharmacol 2017;27(2):205-206.
- Ng B, Postlethwaite A, Rollnik J. Peripheral oedema in patients taking olanzapine. Int Clin Psychopharmacol 2003 Jan;18(1):57-59.
- Kuppili PP, Nebhinani N, Jain S, et al. Olanzapine associated palpebral edema: An uncommon adverse effect of a commonly prescribed drug. Asian J Psychiatr 2018 Aug;36:60-61.
- Herlihy M, Duff E, Sadlier M. Olanzapine-induced progressive facial oedema mimicking Morbihan disease. Clin Exp Dermatol 2023:llad367.
Abstract
Olanzapine, which is used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, substance use disorder, major depressive disorder, and anxiety disorder, may cause edema. In this paper, a case of periorbital edema associated with olanzapine use was discussed. Periorbital edema occurred on the 9th day of treatment in a 26-year-old male patient who was started on olanzapine 10 mg/day with the comorbid diagnoses of bipolar disorder and polysubstance use disorder. The current side effect was associated with olanzapine use and the drug was discontinued. Periorbital edema completely disappeared on the 6th day of olanzapine discontinuation. The patient's treatment related to his psychiatric diagnoses has been completed. No edema was observed during follow-up. As a result, it should not be forgotten that periorbital edema may occur due to olanzapine use.
Keywords
References
- Callaghan JT, Bergstrom RF, Ptak LR, et al. Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 1999;37(3):177-193.
- Gıynaş-Ayhan M, Dağıstan AA, Yılmaz G, et al. Periorbital edema induced by olanzapine: a case report. Anatolian Journal of Psychiatry 2017;18(1):56-58.
- American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.).
- Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of naranjo adverse drug reactions probability scale. Psychiatry Clin Psychopharmacol 2017;27(2):205-206.
- Ng B, Postlethwaite A, Rollnik J. Peripheral oedema in patients taking olanzapine. Int Clin Psychopharmacol 2003 Jan;18(1):57-59.
- Kuppili PP, Nebhinani N, Jain S, et al. Olanzapine associated palpebral edema: An uncommon adverse effect of a commonly prescribed drug. Asian J Psychiatr 2018 Aug;36:60-61.
- Herlihy M, Duff E, Sadlier M. Olanzapine-induced progressive facial oedema mimicking Morbihan disease. Clin Exp Dermatol 2023:llad367.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Psychiatry |
| Journal Section | Case Reports |
| Authors | |
| Early Pub Date | August 19, 2024 |
| Publication Date | October 24, 2024 |
| Submission Date | January 21, 2024 |
| Acceptance Date | January 31, 2024 |
| Published in Issue | Year 2024 |