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GENÇ ERKEK HASTALARDA SPİNAL BLOK SIRASINDA GELİŞEN VAZOVAGAL SENKOPA MİDAZOLAM PREMEDİKASYONUNUN ETKİSİ: RETROSPEKTİF BİR ÇALIŞMA

Year 2024, Volume: 4 Issue: 11, 124 - 129, 24.10.2024
https://doi.org/10.54270/atljm.2024.60

Abstract

Amaç: Vazovagal senkop arteriyel kan basıncının ve serebral kan akışının azalmasından kaynaklanan ani bilinç kaybıdır.
Gereç ve Yöntem: ASA I-II, 18-45 yaş aralığında, elektif şartlarda spinal anestezi uygulanan 133 erkek hastanın anestezi kayıtları retrospektif olarak incelendi. Premedikasyon uygulanan ve uygulanmayan hastaların anestezi kayıtlarında yer alan hemodinamik veriler ve spinal anesteziye bağlı gelişen fenalaşma hissi, hipotansiyon, senkop ve asistoli kayıtları incelendi ve iki grup hastanın verileri istatistiksel olarak karşılaştırıldı. Verilerin analizinde bağımsız örneklem t test, mann-whitney u, ki-kare test, ki-kare test koşulları sağlanmadığında fischer test kullanıldı.
Bulgular: Spinal anestezi öncesi midazolam kullanan grupta anksiyete oranı midazolam kullanmayan gruptan anlamlı olarak daha yüksekti (p<0,05). Midazolam kullanan ve kullanmayan gruplar arasında spinal sırasında ve spinal öncesi hemodinamik verilerde anlamlı farklılık görülmedi (p>0,05). Midazolam kullanılmayan grupta bradikardi, senkop, fenalaşma oranı midazolam kullanılan gruptan anlamlı (p<0,05) olarak daha yüksekti. Midazolam kullanılan grupta yatar pozisyon oranı midazolam kullanmayan gruptan anlamlı olarak daha düşüktü (p<0,05).Midazolam kullanan ve kullanmayan gruplar arasında efedrin, atropin kullanımı benzer bulundu (p>0,05).
Sonuç: Sonuçlarımız spinal anestezi öncesi uygulanan midazolam sedasyonunun genç erkek hastalarda spinal blok sırasında görülen bradikardi, fenalaşma ve senkopu önlemede etkin olabildiğini göstermektedir.

References

  • Ma J, Tian X, Deng L. Recurrent Syncope Episodes during Spinal Anesthesia for Perianal Abscess Drainage: A Case Report Emphasizing Pain as a Trigger. Am J Case Rep. 2023; 26:24.
  • Longo S, Legramante JM, Rizza S, Federici M. Vasovagal syncope: An overview of pathophysiological mechanisms. Eur J Intern Med. 2023;112:6-14.
  • Kinsella SM, Tuckey JP. Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex. Br J Anaesth. 2001;86(6):859-68.
  • Bamgbade OA. Severe Needle Phobia in the Perianesthesia Setting, Journal of PeriAnesthesia Nursing, 2007; 22:322-329.
  • Arthur W, Kaye GC. The pathophysiology of common causes of syncope. Postgrad Med J. 2000;76(902):750-3.
  • Makkar JK, Jain D, Jain K, Pareek A. Vasovagal mediated cardiac arrest during epidural catheter insertion in a patient with previous uneventful surgeries under regional anesthesia. J Anaesthesiol Clin Pharmacol. 2018;34(2):268-269.
  • Fredrikson M, Furmark T. Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders. Ann N Y Acad Sci. 2003;985:341-7.
  • Serletis A, Rose S, Sheldon AG, Sheldon RS. Vasovagal syncope in medical students and their first-degree relatives. Eur Heart J. 2006;27: 1965–70.
  • Matveeva N, Titov B, Bazyleva E, Pevzner A, Favorova O. Towards Understanding the Genetic Nature of Vasovagal Syncope. Int J Mol Sci. 2021; 24;22(19):10316.
  • Khalaji A, Behnoush AH, Tajdini M. Association between vitamin D deficiency and vasovagal syncope: A systematic review and metaanalysis. Clin Cardiol. 2023;46(7):721-28.
  • Behnoush AH, Yazdani K, Khalaji A, Tavolinejad H, Aminorroaya A, Jalali A, Tajdini M. Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network metaanalysis of randomized controlled trials. Heart Rhythm. 2023;20(3):448-60.
  • DeLeon AM, Rivera-Monfeli J, Akbar TA, DeCaria B. Vasovagal Syncope and Transient Asystole During Peripheral Nerve Blockade. Cureus. 2023;22:15.
  • Ekinci M, Gölboyu BE, Dülgeroğlu O, Aksun M, Baysal PK, Çelik EC, Yeksan AN. The relationship between preoperative anxiety levels and vasovagal incidents during the administration of spinal anesthesia. Rev Bras Anestesiol. 2017;67(4):388-94.
  • Kindler CH, Harms C, Amsler F, Ihde-Scholl T, Scheidegger D. The visual analog scale allows effective measurement of pre‐operative anxiety and detection of patient’s anesthetic concerns. Anesth Analg. 2000;90: 706-712.
  • Wetsch WA, Pircher I, Lederer W, Kinzl JF, Traweger C, Heinz-Erian P, Benzer A. Preoperative stress and anxiety in day‐care patients and inpatients undergoing fast‐track surgery. Br J Anaesth. 2009;103:199-205.
  • Mitchell M. Conscious surgery: influence of the environment on patient anxiety. J Adv Nurs. 2008;(64): 261-71.
  • Caumo W, Schmidt AP, Schneider CN, Bergmann J, Iwamoto CW, Adamatti LC, Bandeira D, Ferreira MB. Risk factors for postoperative anxiety in adults. Anaesthesia. 2001;(56): 720-28.
  • Pachon-M JC. Neurocardiogenic syncope: Pacemaker or cardioneuroablation? Heart Rhythm. 2020;17:829-30.
  • Mikesell CE, Atkinson DE, Rachman BR. Prolonged QT Syndrome and Sedation A Case Report and a Review of the Literature. Pediatric Emergency Care, 2011; 27:2.
  • Sprung J, Abdelmalak B, Schoenwald PK. Vasovagal Cardiac Arrest During the Insertion of an Epidural Catheter and Before the Administration of Epidural Medication Anesth Analg. 1998;86:1263-5.
  • Sanuki T, Kishimoto N, Kuroda H, Kido K. Hypotension Without Skin Symptoms at Local Anesthesia in Dental Treatment: Anaphylaxis? Or Vasovagal Reaction? Anesth Prog. 2023;70(2):91-2.
Year 2024, Volume: 4 Issue: 11, 124 - 129, 24.10.2024
https://doi.org/10.54270/atljm.2024.60

Abstract

References

  • Ma J, Tian X, Deng L. Recurrent Syncope Episodes during Spinal Anesthesia for Perianal Abscess Drainage: A Case Report Emphasizing Pain as a Trigger. Am J Case Rep. 2023; 26:24.
  • Longo S, Legramante JM, Rizza S, Federici M. Vasovagal syncope: An overview of pathophysiological mechanisms. Eur J Intern Med. 2023;112:6-14.
  • Kinsella SM, Tuckey JP. Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex. Br J Anaesth. 2001;86(6):859-68.
  • Bamgbade OA. Severe Needle Phobia in the Perianesthesia Setting, Journal of PeriAnesthesia Nursing, 2007; 22:322-329.
  • Arthur W, Kaye GC. The pathophysiology of common causes of syncope. Postgrad Med J. 2000;76(902):750-3.
  • Makkar JK, Jain D, Jain K, Pareek A. Vasovagal mediated cardiac arrest during epidural catheter insertion in a patient with previous uneventful surgeries under regional anesthesia. J Anaesthesiol Clin Pharmacol. 2018;34(2):268-269.
  • Fredrikson M, Furmark T. Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders. Ann N Y Acad Sci. 2003;985:341-7.
  • Serletis A, Rose S, Sheldon AG, Sheldon RS. Vasovagal syncope in medical students and their first-degree relatives. Eur Heart J. 2006;27: 1965–70.
  • Matveeva N, Titov B, Bazyleva E, Pevzner A, Favorova O. Towards Understanding the Genetic Nature of Vasovagal Syncope. Int J Mol Sci. 2021; 24;22(19):10316.
  • Khalaji A, Behnoush AH, Tajdini M. Association between vitamin D deficiency and vasovagal syncope: A systematic review and metaanalysis. Clin Cardiol. 2023;46(7):721-28.
  • Behnoush AH, Yazdani K, Khalaji A, Tavolinejad H, Aminorroaya A, Jalali A, Tajdini M. Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network metaanalysis of randomized controlled trials. Heart Rhythm. 2023;20(3):448-60.
  • DeLeon AM, Rivera-Monfeli J, Akbar TA, DeCaria B. Vasovagal Syncope and Transient Asystole During Peripheral Nerve Blockade. Cureus. 2023;22:15.
  • Ekinci M, Gölboyu BE, Dülgeroğlu O, Aksun M, Baysal PK, Çelik EC, Yeksan AN. The relationship between preoperative anxiety levels and vasovagal incidents during the administration of spinal anesthesia. Rev Bras Anestesiol. 2017;67(4):388-94.
  • Kindler CH, Harms C, Amsler F, Ihde-Scholl T, Scheidegger D. The visual analog scale allows effective measurement of pre‐operative anxiety and detection of patient’s anesthetic concerns. Anesth Analg. 2000;90: 706-712.
  • Wetsch WA, Pircher I, Lederer W, Kinzl JF, Traweger C, Heinz-Erian P, Benzer A. Preoperative stress and anxiety in day‐care patients and inpatients undergoing fast‐track surgery. Br J Anaesth. 2009;103:199-205.
  • Mitchell M. Conscious surgery: influence of the environment on patient anxiety. J Adv Nurs. 2008;(64): 261-71.
  • Caumo W, Schmidt AP, Schneider CN, Bergmann J, Iwamoto CW, Adamatti LC, Bandeira D, Ferreira MB. Risk factors for postoperative anxiety in adults. Anaesthesia. 2001;(56): 720-28.
  • Pachon-M JC. Neurocardiogenic syncope: Pacemaker or cardioneuroablation? Heart Rhythm. 2020;17:829-30.
  • Mikesell CE, Atkinson DE, Rachman BR. Prolonged QT Syndrome and Sedation A Case Report and a Review of the Literature. Pediatric Emergency Care, 2011; 27:2.
  • Sprung J, Abdelmalak B, Schoenwald PK. Vasovagal Cardiac Arrest During the Insertion of an Epidural Catheter and Before the Administration of Epidural Medication Anesth Analg. 1998;86:1263-5.
  • Sanuki T, Kishimoto N, Kuroda H, Kido K. Hypotension Without Skin Symptoms at Local Anesthesia in Dental Treatment: Anaphylaxis? Or Vasovagal Reaction? Anesth Prog. 2023;70(2):91-2.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Anaesthesiology
Journal Section Research Articles
Authors

Ergün Gündüz 0000-0002-5344-8250

Early Pub Date August 15, 2024
Publication Date October 24, 2024
Submission Date April 30, 2024
Acceptance Date May 24, 2024
Published in Issue Year 2024 Volume: 4 Issue: 11

Cite

Vancouver Gündüz E. GENÇ ERKEK HASTALARDA SPİNAL BLOK SIRASINDA GELİŞEN VAZOVAGAL SENKOPA MİDAZOLAM PREMEDİKASYONUNUN ETKİSİ: RETROSPEKTİF BİR ÇALIŞMA. ATLJM. 2024;4(11):124-9.