ATTRACTIVE APPROACHES in DRUG DELIVERY: BIO-BASED CARRIERS for siRNA TARGETING

Year 2018, Volume: 7 Issue:1, 74 - 89, 28.02.2018

Zülal Yalınca Şükrü Tüzmen

https://doi.org/10.18036/aubtdc.315579

Abstract

Functional
characterization of genes can be determined by disruption of gene expression.
This provides powerful approach in designing novel treatment strategies. RNA
interference (RNAi) is a natural phenomenon that can aid in the study of
post-transcriptional regulation of genes. This mechanism can be stimulated via
introduction of double stranded RNA (dsRNA) in a cell. Synthetic short/small interfering
RNAs (siRNA) can be utilized to trigger down-regulation of desired genes via
transfecting into mammalian cells. Recently, utilization of bio-based polymers
has been an attractive approach in drug delivery for medical applications. This
review article describes the advantages of exploiting bio-based polymeric
carriers for siRNA targeting, as bio-therapeutics. Here, we report the current
developments, safety and delivery of bio-based siRNAs via polymeric carriers.
Additionally, cancer genetics and metabolic disorders including obesity and
diabetes pertaining to the progress in clinical applications have been
highlighted.

Keywords

siRNA, bio-therapeutics, post-transcriptional regulation

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