Abstract
Santral sinir sisteminde çeşitli nöropeptidlerin fragmanlarının, esas nöropeptidinkilere benzer veya farklı etkilerinin bulunduğu gösterilmiştir. Bu çalışmada, oksitosinin fragmanları olan OXT (4-9) ve OXT (5-8)'in bir koşullu kaçış cevabının sönmesi üzerine etkileri sunulmuştur. OXT (4-9) bütün dozlarda sönmeyi fasilite eder, hatırlamayı bozarken, OXT (5-8) kullanıldığında aynı sonuçlar sadece yüksek dozlarda elde edilmiştir. Bu sonuçler, muhtemelen, dokuz pozisyonundaki glisin aminoasidinin özellikle bellek pekişmesi ve hatırlama olaylarında önemli olabileceğini göstermektedir.
References
- 1.Ayhan S : Sentetik met-enkefalin benzeri FK. 33824'ün sıçanlarda şartlı kaçış cevapları kazanılmasına etkisi. Ankara Tıp Bülteni 6 : 177-188, 1984.
- 2.Ayhan S5 Ocakçıoğlu EB : Oksitosinin bellek üzerine etkisi. Journal of Ankara Medical School (baskıda).
- 3.Burbach J Peter H Bohus B Kovâcs GL Van Nispen JW Greven MH : Oxytocin is a precursor of potent behaviouraily active neuropeptides. European Journal of Pharmacology 54 ; 125-131, 1983,
- 4.De Wied D Gaffari D Burbach PH Kovâcs GL Van Ree JM : Structure activity relationship studies with c-terminal fragrients ol vasopressin and oxytocin on avoldance behaviors of rats. The Journal of Pharmacology an Experimental 'Therapeutics 241 : 268-274, 1987.
- 5.Gaffori DIW De Wied D : Bimodal effect of oxytocin on avoidance behavior may be caused by the presence ol two peptide seguences with opposite action in the same molesule, European Journal of Pharmacology, 147 ; 157-162, 1988.
- 6.Heshimato H Fukui K Moto T Makajima T Kato N : Distribution of vasopressin and oxytocin in rat brain, Endocrinol. Japon. 32 : 89-97, 1985,
- 7.Valiguette G Haldar J Abrams GM Nilaver G Zimmerman EA : Extrahypothalamis neurohypophysial peptides in tbe rat central nervous system, Brain Research 301 : 176-170, 1985.
- 8.Waltor R Hoffman PL Flexner LB : Neuro hypophyseal hormones, analogs and İrag'nenis : Their effect on puromycin induced anınesia. Proc. Nat. Acad. Sci, V.S.A, 72 : 4180-4184, 1975,
- 9.Walter R Van Ree JM De Wied D ; Moedification of conditioned behavior of rats by neurohypophyseal hornones and analogues. Proc. Natl. Acad. Sci. U.S.A, 75 : 2493, 1978,
- 10.Zimmerman EA Nilaver G Hou-Yu A Silverman AS ; Vasopressinergic and oxytocinergic patlıways in the central nervous system. Federation Proc. 43 : 91- 96, 184,
Abstract
li was demonsirated thet in the central nervous system, fragment$ of various neuropeptides showed eflecis thet were similar to or different from the effects of the main nsuropeptide. Similerliy, the effects of certain fragments of oxytocin on behaviour was shown. In this repori we presented the citects of the fragmenis of oxytocin, OXT (4-9) and OXT (5-8) on ezxtinction of a conditioned avolidance response (E.C.A,R), In extinction test that the İfragment of oxytocin, OXT (4-9) have been injecied Ihr before the sessions, decreased responses (E.C.A.R.) were observed in comparison to saline injected control group, İt was observed that the results of 190
4g/ke doses of OXT (5-3) administered animals were not different from the controls while responses (E.C.AR)J of 200 pg/kg doses of OXT (5-8) injected animals weredeöcregsed. in retention tesis, administration of OXT (4-9) disturked retrieval process in all doses. When OKT (5-8) was injected, ii was mot effected by the doses of 190 ug/ke, but attenuated by higher doses, 209 ug /ke. İn conclusion, the fragment of oxytocin, OXT (4-9), facilitated extinction and disturbed retrieval
in all doses but OXT (5-8) caused same results only at higher doses. These results probably suggesisd that giycine aminoacid in position
nine may be important especialiy in memory consolidation and retrievel.
References
- 1.Ayhan S : Sentetik met-enkefalin benzeri FK. 33824'ün sıçanlarda şartlı kaçış cevapları kazanılmasına etkisi. Ankara Tıp Bülteni 6 : 177-188, 1984.
- 2.Ayhan S5 Ocakçıoğlu EB : Oksitosinin bellek üzerine etkisi. Journal of Ankara Medical School (baskıda).
- 3.Burbach J Peter H Bohus B Kovâcs GL Van Nispen JW Greven MH : Oxytocin is a precursor of potent behaviouraily active neuropeptides. European Journal of Pharmacology 54 ; 125-131, 1983,
- 4.De Wied D Gaffari D Burbach PH Kovâcs GL Van Ree JM : Structure activity relationship studies with c-terminal fragrients ol vasopressin and oxytocin on avoldance behaviors of rats. The Journal of Pharmacology an Experimental 'Therapeutics 241 : 268-274, 1987.
- 5.Gaffori DIW De Wied D : Bimodal effect of oxytocin on avoidance behavior may be caused by the presence ol two peptide seguences with opposite action in the same molesule, European Journal of Pharmacology, 147 ; 157-162, 1988.
- 6.Heshimato H Fukui K Moto T Makajima T Kato N : Distribution of vasopressin and oxytocin in rat brain, Endocrinol. Japon. 32 : 89-97, 1985,
- 7.Valiguette G Haldar J Abrams GM Nilaver G Zimmerman EA : Extrahypothalamis neurohypophysial peptides in tbe rat central nervous system, Brain Research 301 : 176-170, 1985.
- 8.Waltor R Hoffman PL Flexner LB : Neuro hypophyseal hormones, analogs and İrag'nenis : Their effect on puromycin induced anınesia. Proc. Nat. Acad. Sci, V.S.A, 72 : 4180-4184, 1975,
- 9.Walter R Van Ree JM De Wied D ; Moedification of conditioned behavior of rats by neurohypophyseal hornones and analogues. Proc. Natl. Acad. Sci. U.S.A, 75 : 2493, 1978,
- 10.Zimmerman EA Nilaver G Hou-Yu A Silverman AS ; Vasopressinergic and oxytocinergic patlıways in the central nervous system. Federation Proc. 43 : 91- 96, 184,
Details
| Primary Language | English |
|---|---|
| Subjects | Physiopathology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 30, 1991 |
| IZ | https://izlik.org/JA99DG26TD |
| Published in Issue | Year 1991 Volume: 44 Issue: 3 |