Yeni Bir Endojen Peptid : Nöropeptid-Y (Npy)

Year 1987, Volume: 40 Issue: 1 , 75 - 84 , 31.03.1987

Cankat Tulunay

https://izlik.org/JA46WE73HD

Abstract

NPY 1982 yılında domuz beyninden izole edilmiş daha sonrada in- san beyninde yaygın olarak dağıldığı saptanmış endojenöz bir pep- tiddir. Peptidin amino ve karboksil terminallerinde Tirozin amino- asidinin bulunması nedeniyle bu isim verilmiştir. Yapılan çalışmalar- da NPY beyinde diğer peptidlerden daha fazla miktarlarda bulunmuş- tur. Bu nedenle fizyolojik ve patotizyolojik durumlarda önemli biyo- lojik aktiviteye sahip olabileceği düşünülerek üzerinde yoğun bir ilgi odaklanmıştır. Radioimmünoassay ve immünositokimyasal değerlen- dirmelerde NPY gerek santralde gerekse periferde hemen daima ka- tekolaminerjik sistemlerde lokalize olduğu görülmüştür. Bu ko-peptid özelliği onun katekolaminlerle pre ve/veya postsinaptik düzeyde et- kileşerek veya tek basına nörotransmitter/nöromodülatör gibi etkili olabileceğini düşündürür. Gerçektende ilk bulgular bunu destekler gö- rünümdedir. Mevcut araştırma sonuçlarından ortak bir yere ulaşmak şu an için güç görünmekle birlikte hem peptidin literatüre yeni girmiş olması hemde teknik olanakların yetersizliği nedeniyle peptid hakkında son sözü söylemek için vakit henüz erkendir.

Keywords

aminoasit , immünoasitkimyasal , npy

A New Endogenous Peptide: Neuropeptide-Y (Npy)

https://izlik.org/JA46WE73HD

Abstract

NPY is an endogenous peptide isolated from pig brain in 1982 and later found to be widely distributed in human brain. This name was given because of the presence of Tyrosine amino acid at the amino and carboxyl termini of the peptide. Studies have shown that NPY is found in higher amounts in the brain than other peptides. For this reason, it has been focused on with great interest, considering that it may have important biological activity in physiological and pathophysiological conditions. In radioimmunoassay and immunocytochemical evaluations, it has been observed that NPY is almost always localized in catecholaminergic systems, both centrally and peripherally. This co-peptide feature suggests that it may be effective as a neurotransmitter/neuromodulator by interacting with catecholamines at pre- and/or postsynaptic levels or alone. Indeed, initial findings seem to support this. Reaching a common ground from the current research results

Keywords

npy , amino acid , immunocytochemistry

References

• i. Adrian, TE, Allen, J.M. Bloom, S.R., Chatsi, M.A,, Rossor, M.N, Roberts, G.W., Crow, T.J., Tatemoto, K., Polak J.M. : Neuropeptide Y distribution in human brain Nature, 306 : 584-686, 1983.
• 2. Adrian, TE. Allen, J.M, Tatemoto, K., Polak, J.M,, Bloom, S.R. : Neuropeptide Y in the human male genital tract Life sciences, 35 : 2843-48, 1984.
• 3. Adrian, TE. Allen, IM, Terenghi, G., Bacarase-Hamilton, AJ. Brown, M.I. Polak, J.M. : Neuropeptide Y in phaeochromocytomas and ganglioncurohlastomas. Lancet, 2 : 540-42, 1983,
• 4, Adrian, T.E., Savage, A.P., Bacarase-Hamilton, AJ,, Woofe K.D., Besterman, H.S., Bloom, S.R. : PYY, a new colonic hörmöne : changes in gastrointestinal diseaseş, Crut, 25 : A1150, 1904.
• 5-Allen, J.M, Ferrier, N., Adrian, TE, Crow, T.J., Bloom, SIR. : Distribution of neuropeptide Y in post mortem human brain from normal and schizophrenic subjects. Clin, Sci., 65 : P19, 1983.
• 6-Allen, J.M, Gibson, S.J.. Adrian, T.E., Polak, J.M. Bloom, 5.R. : Neuropeptide Yin human spinal cord, Brain Research, 308 : 145-48, 1984. Allen, J.M., McGregor, G.P., Adrian, T.E., Bloom, S.R., Zhang, 5.0,, Ennis, K.'W,,
• 7-Unger, W.G. : Reduction of neuropeptide Y (NPY) in the rabbit iris-ciliary body alter chronic sympathectomy. Exe. Eye Res., 37 : 2183-15, 1983. Allen, J.M., MeGregor, G.P., Woodhams, P.L., Polak, J.M, Bloom, S.R. : Ontogeny a novel peptide, neuropeptide Y (NPY) in rat brain. Brain Research, 303 : 107-200, 1904.
• 8-Allen, J.M., Schon F. Todd N., Yeats J.C. Crockard, H.A. Bloom, S.R. : Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasosnazm. Lancet, 2 : 550-52, 19B4. Allen, Y.S., Roberts, G.W., Bloom, S.R., Grow, T.J., Polak, J.M. : Neuropeptide Y in the stria terminalis : evidence for an amygdalofugal projection. Brain Research, 321 :357-62, 1984.
• 9-Andrews, P.C., Hawke, D., Shively, J.E.. Dixon, JE. : A nomanidated peptide homologous to porcine peptide YY and neuropeptide YY. Endocrinology, 116 : 2677-81, 1985. Chronwall, B.M., Di Moggio, D.A,, Massari, V.J., Pickel, V.M., Ruggiero, D.A,
• ©'Donaohue, T.L. : The anatomy of neuropeptde-Y-containing neurons in rat brain Neuroscionce, 15 ; 1159-81, 1985. i Clark, J.T., Kalra, P.5., Crowley, W.R., Kalra, S.P. : Neuropeptide Y and human panecreatic polypeptide stimulate fseding behavior in rats. Endocrinology, 115 : d2'7-a9, 1984,
• Corder, R., Emson, P.C,, Lowry, PJ, : Purification and characterization of human neuropeptide Y from adrenal-medullary phaeochromocytona tissuo, Biochem. J., 218 : 689-706, 1984. i
• Dawbotn, D., Hunt, S.P, Emson, P.C. : Neuropeptide Y : regional distribution chromatographic characterization and immunocytochemical demonstration in post mortem human brain. Brain Research, 296 : 168-173, 1984.
• Edvinsson, L., Emson, P., MeCullah, J. Tatemoto, K., Uddman, R. : Neuropeptide Y : Immunocytechemical localization to and effect upon feline pial arteries and veins in vitro and in situ, Acta Physiol, Scand., 122 : 155-63, 198
• Everitt, B.J., Höktelt, T., Terenius, L., Tatemoto, K., Mutt, V. Galdstein, M. : Differential co-existence of neuropeptide Y (NPY)-ike immunorsactivity wit catecholamines in (he central nervous system of the rat. Neuroscience, 11 : 443-62, 1984. Iveli, R., Emson, P., Richter, D. : Human neuropeptide Y, somatostatin and vasopressin precursors identified in cell-free translations of hypoihalamic m-ANA, Febs, 177 : 175-78, 1984.
• Kalra, SP., Crowley, V.E. : Norepinephrine-like eftects of neuropeptide Y on reicase in ihe rat. life Selences, 35 : 1178-76, 1984, Lundberg, J.M, Stjarne, L. : Neuropeptide Y (NP'Y) depresses the secretion ol 3 H-noradrenaline and the contractile response evoked by field stimulation, in Tat vas delerens. Acta Physiol. Scand. 120 : 477-79, 1984.
• Lundberg, J.M., Xiao-Ying Hua, Franco-Cereceda, A. : Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas delerens and urina/y biadder of (he guinea-pig- Acta Phystol. Scand., 121 : 325-32, 1984.
• Moore, R.Y., Gustafson, E.L,, Card, J.P. : Identical immunoreactivity of aferents to the ref suprachiasmatic nucleus with antisera against aviân pancreatic polypeptide, molluscan cardioexcitatory peptide and neuropeptide Y. Cell Tissue Res,, 236 : 41-46, 19B4.
• Owman, Ch., Hardebo, J.E. : Neuropeptide-Y in cerebrovaskuler adrenergic nerves, Cephelalgia, Supp. 4 : 56-57, 1986. Stanley, B.G, Leibowitz, S.F. : Neuropeptide Y : Stimulatlon of fceding and drinking by injection into the paraventricular nucleus. Life sciences, 35 ; 2635-42, 1984.
• Unden, A., Bartfai, T. : Regulation of neuropeptide Y (NPY) binding by guanin& nudleotides in the rat cerebral cortex. Febs, 177 : 125-28, 1904. Fini, 1, Pich, M., Fuxe, K., Lensi, P.L, Agnati, LE. Harfsirand, A., Mutt, v. “TTatsmota, K, Moscara, K. Actions ol cenirealiy administered neuropeptide Y on EKG activity in diffterents phases of t(htir circulation eyclo. Acta Physiol, Scand.122: 71-77, 1984,