Research Article
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Tobacco Pharmacology Toxins,

Year 1980, Volume: 33 Issue: 3 , 497 - 506 , 30.09.1980
https://izlik.org/JA54AU88KH

Abstract

In order to fully understand the effects of tobacco on human health, it is necessary to know its pharmacology and toxicology. The pharmacological and toxic effects of tobacco depend partly on the substances present in tobacco and partly on the «pyrolysis» products formed during the combustion of a cigarette, pipe or cigar. It is accepted that there are more than 2000 chemical substances in cigarette smoke (19). In terms of pharmacology and toxicology, the most important substances found in smoke are nicotine, carbon monoxide (CO) and the substances in the particulate phase of smoke, which are the basis of tar.

References

  • 1. Backett AH, Garrod J W, Jenner P : The Effect of Smoking on Nicotine Metabolism in vivo in Man, J Pharm Pharmacol 23 : 62, 1971
  • 2. Gadek JE, Fella GA, Crystal RG : Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans, Science 206 : 1315, 1979
  • 3. Deneau GA, Inoki R : Nicotine Self-Administration in Monkeys, Ann NY Acad Sci 142 : 177, 1967
  • 4. Hanson HM, Ivester CA, Morton BR : Nicotine Self-Administration in Rats. In : Kras negor, N. ed. Cigarette Smoking as a Dependence Process, pp. 4-23. National Institute on Drug Abus
  • Research Monograh 23. DHEW Pub. No. (ADM) 79-800, Washington, D.C., 179 6. Janoff A ve ark : Cigarette Smoke Inhalation Decreases a, -Antitriypsin Activity in Rat Lung, Science 206 : 1313, 1979
  • 7. Jarvik ME : Tolerance to the Effects of Tobacco. In : Krasnegor, N. ed Cigarette Smo• king as a Dependence Process, pp. 150-157. National Institute on Drug Abuse Research Monograph 23. DHEW Pub. No. (ADM) 79-800. Washington, D.C., 1979
  • 8. Jarvik ME : Biological Influences on Cigarette Smoking. In : Krasnegor, N. ed, The Behavioral Aspects of Smoking, pp. 7-45. National Institute on Drug Abuse Research Monograph 26.
  • DHEW Pub. No. (ADM) 79-882, Washington, D.C., 1979
  • 9. Jones RT, Farrel TR Ill, Herning RI : Tobacco Smoking and Nicotine Tolerance. In : Krasnegor, N. ed. Self-Administration of Abused Substances : Methods for Study, pp. 202-208. National Institute on Drug Abuse Research Monograph 20. DHEW Pub. No. (ADM) 78-727. Washington, D.C. 1978
  • 10. Karmazyn M, Manku MS, Horrobin DF : The Mechanism of Coronary Artery Sposm : Roles of Oxygen, Prostaglandins, Sex Hormones and Smoking, Medical Hypotheses 5 : 447, 1979
  • 11. Kaÿmakçalan S, Kaymakçalan S : Sigara dumanmrn Akut Farmakolojik Tesirlerinin Tecrübe Hayvanlarrnda Tetkikine Ait özel Bir Metod, A (j TIP Fak Mec 15 : 436, 1962
  • 12. Kaymakçalan $ ve ark : Comparison of the Cardiovascular Effect of Regular arid Fil ter-tip Cigarette Smoke, Arzneim Forsch 18 : 817, 1968
  • 13. Kaymakçalan $ : Tütün ve Kanser (Onkoloji Yaymlarmdan), 1967 Yeni Desen Tic. Ltd., $ti. Matbaasl, Ankara
  • 14. Kaymakçalan $ : Deney Hayvanlarmda ilaçlarm Self-Administrasyonu, A Ü TIP Fak Mec 26 : 463, 1973 $iikrii
  • 15. Kershbaum A ve ark : Filter-Tip, and Modified Cigarettes. Nicotine Excretion, Free Fatty Acid Mobilization, and Catecholamine Excretion, J A M A 201 : 545, 1967
  • 16. özden AM : TIP Müfredatl Farmakodinami ve Tedavi Dersleri, 4. Tabl, 1940, Ekspres Baymevi, istanbul, Sayfa : 427
  • 17. Shiffman SM : The Tobacco Withdrawal Syndrone. In : Krasnegor, N. ed. Cigarette Smoking as a Dependence Proces, pp. 158-184. National Institute on Drug Abuse Research
  • Monograph 23, DHEW Pub. No. (ADM) 79-800, Washington D.C., 1979
  • 18. U.S. Department of Health, Education, and Welfare, ' Public Health Service. General of teh Public Health Service, P.H.S. Publication No. 1103, U.S. Government Printig Office, 1964
  • 19. U.S. Department of Health, Education, and Welfare, Public Health Service. Smoking and Health, A Report of the Surgeon General, P.H.S. Publication No. 79-50066, U.S. Government
  • Printing Office, 1979
  • 20. Volle RL, Koelle GB : Ganglionic Stimulating and Blocking Agents. In. Goodman, L.S. and Gilman, A. eds. Thc Pharmacological Basis of Therapeutics. Fifth Edition, 1975 Mcmillan
  • Publishing Co., New York, Sayfa : 569
  • 21. Wennmalm A : Cigarette Smoking, Prostaglandins and Reactive Hyperemia, Prostaglan dings and Medicine 3 : 321, 1979
  • 22. Yanagita T : An Experimental Framework for Evaluation of Dependence Liability of Various Types of Drugs in Monkeys, Bull Narcotics 25 : 57, 1973

Tütün Farmakolojisi Tokleri

Year 1980, Volume: 33 Issue: 3 , 497 - 506 , 30.09.1980
https://izlik.org/JA54AU88KH

Abstract

Tütünün insan sağlığına olan etkilerinin iyice anlaşılabilmesi için farmakoloji Ve toksikolojisinin bilinmesi gerekir. Tütünün farmakolojik ve toksik etkileri kısmen tütünde mevcut olan maddelere, kısmen de sigara, pipo veya püronun, yanması esnasında teşekkül eden «piroliziz» ürünlerine bağlıdır, Sigara dumanında 2000'den fazla kimyasal maddenin bulunduğu kabul edilmektedir (19). Farmakoloji ve toksikoloji bakımından dumanda bulunan en önemli maddeleri nikotin, karbonmonoksid (CO) ve katranın esasım teşkil eden dumanın partikül fazındaki maddeler teşkil etmektedir.

References

  • 1. Backett AH, Garrod J W, Jenner P : The Effect of Smoking on Nicotine Metabolism in vivo in Man, J Pharm Pharmacol 23 : 62, 1971
  • 2. Gadek JE, Fella GA, Crystal RG : Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans, Science 206 : 1315, 1979
  • 3. Deneau GA, Inoki R : Nicotine Self-Administration in Monkeys, Ann NY Acad Sci 142 : 177, 1967
  • 4. Hanson HM, Ivester CA, Morton BR : Nicotine Self-Administration in Rats. In : Kras negor, N. ed. Cigarette Smoking as a Dependence Process, pp. 4-23. National Institute on Drug Abus
  • Research Monograh 23. DHEW Pub. No. (ADM) 79-800, Washington, D.C., 179 6. Janoff A ve ark : Cigarette Smoke Inhalation Decreases a, -Antitriypsin Activity in Rat Lung, Science 206 : 1313, 1979
  • 7. Jarvik ME : Tolerance to the Effects of Tobacco. In : Krasnegor, N. ed Cigarette Smo• king as a Dependence Process, pp. 150-157. National Institute on Drug Abuse Research Monograph 23. DHEW Pub. No. (ADM) 79-800. Washington, D.C., 1979
  • 8. Jarvik ME : Biological Influences on Cigarette Smoking. In : Krasnegor, N. ed, The Behavioral Aspects of Smoking, pp. 7-45. National Institute on Drug Abuse Research Monograph 26.
  • DHEW Pub. No. (ADM) 79-882, Washington, D.C., 1979
  • 9. Jones RT, Farrel TR Ill, Herning RI : Tobacco Smoking and Nicotine Tolerance. In : Krasnegor, N. ed. Self-Administration of Abused Substances : Methods for Study, pp. 202-208. National Institute on Drug Abuse Research Monograph 20. DHEW Pub. No. (ADM) 78-727. Washington, D.C. 1978
  • 10. Karmazyn M, Manku MS, Horrobin DF : The Mechanism of Coronary Artery Sposm : Roles of Oxygen, Prostaglandins, Sex Hormones and Smoking, Medical Hypotheses 5 : 447, 1979
  • 11. Kaÿmakçalan S, Kaymakçalan S : Sigara dumanmrn Akut Farmakolojik Tesirlerinin Tecrübe Hayvanlarrnda Tetkikine Ait özel Bir Metod, A (j TIP Fak Mec 15 : 436, 1962
  • 12. Kaymakçalan $ ve ark : Comparison of the Cardiovascular Effect of Regular arid Fil ter-tip Cigarette Smoke, Arzneim Forsch 18 : 817, 1968
  • 13. Kaymakçalan $ : Tütün ve Kanser (Onkoloji Yaymlarmdan), 1967 Yeni Desen Tic. Ltd., $ti. Matbaasl, Ankara
  • 14. Kaymakçalan $ : Deney Hayvanlarmda ilaçlarm Self-Administrasyonu, A Ü TIP Fak Mec 26 : 463, 1973 $iikrii
  • 15. Kershbaum A ve ark : Filter-Tip, and Modified Cigarettes. Nicotine Excretion, Free Fatty Acid Mobilization, and Catecholamine Excretion, J A M A 201 : 545, 1967
  • 16. özden AM : TIP Müfredatl Farmakodinami ve Tedavi Dersleri, 4. Tabl, 1940, Ekspres Baymevi, istanbul, Sayfa : 427
  • 17. Shiffman SM : The Tobacco Withdrawal Syndrone. In : Krasnegor, N. ed. Cigarette Smoking as a Dependence Proces, pp. 158-184. National Institute on Drug Abuse Research
  • Monograph 23, DHEW Pub. No. (ADM) 79-800, Washington D.C., 1979
  • 18. U.S. Department of Health, Education, and Welfare, ' Public Health Service. General of teh Public Health Service, P.H.S. Publication No. 1103, U.S. Government Printig Office, 1964
  • 19. U.S. Department of Health, Education, and Welfare, Public Health Service. Smoking and Health, A Report of the Surgeon General, P.H.S. Publication No. 79-50066, U.S. Government
  • Printing Office, 1979
  • 20. Volle RL, Koelle GB : Ganglionic Stimulating and Blocking Agents. In. Goodman, L.S. and Gilman, A. eds. Thc Pharmacological Basis of Therapeutics. Fifth Edition, 1975 Mcmillan
  • Publishing Co., New York, Sayfa : 569
  • 21. Wennmalm A : Cigarette Smoking, Prostaglandins and Reactive Hyperemia, Prostaglan dings and Medicine 3 : 321, 1979
  • 22. Yanagita T : An Experimental Framework for Evaluation of Dependence Liability of Various Types of Drugs in Monkeys, Bull Narcotics 25 : 57, 1973
There are 25 citations in total.

Details

Primary Language English
Subjects Chest Diseases
Journal Section Research Article
Authors

Şükrü Kaymakçalan This is me

Publication Date September 30, 1980
IZ https://izlik.org/JA54AU88KH
Published in Issue Year 1980 Volume: 33 Issue: 3

Cite

APA Kaymakçalan, Ş. (1980). Tobacco Pharmacology Toxins,. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 33(3), 497-506. https://izlik.org/JA54AU88KH
AMA 1.Kaymakçalan Ş. Tobacco Pharmacology Toxins,. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1980;33(3):497-506. https://izlik.org/JA54AU88KH
Chicago Kaymakçalan, Şükrü. 1980. “Tobacco Pharmacology Toxins”,. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33 (3): 497-506. https://izlik.org/JA54AU88KH.
EndNote Kaymakçalan Ş (September 1, 1980) Tobacco Pharmacology Toxins,. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33 3 497–506.
IEEE [1]Ş. Kaymakçalan, “Tobacco Pharmacology Toxins”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 33, no. 3, pp. 497–506, Sept. 1980, [Online]. Available: https://izlik.org/JA54AU88KH
ISNAD Kaymakçalan, Şükrü. “Tobacco Pharmacology Toxins”,. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33/3 (September 1, 1980): 497-506. https://izlik.org/JA54AU88KH.
JAMA 1.Kaymakçalan Ş. Tobacco Pharmacology Toxins,. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1980;33:497–506.
MLA Kaymakçalan, Şükrü. “Tobacco Pharmacology Toxins”,. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 33, no. 3, Sept. 1980, pp. 497-06, https://izlik.org/JA54AU88KH.
Vancouver 1.Şükrü Kaymakçalan. Tobacco Pharmacology Toxins,. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1980 Sep. 1;33(3):497-506. Available from: https://izlik.org/JA54AU88KH