Normal Şahıslarda Uzun ve Kısa Zincirli Yağ Asitlerinin İmmünoreaktifF İnsülin Dinamiğine Etkileri

Year 1974, Volume: 27 Issue: 1-2, 62 - 80, 30.06.1974

Gürbüz Erdoğan

https://izlik.org/JA47HN95BJ

Abstract

ideal ağırlığında ve diabetik olmayan 22 sıhhatli şahısta kısa ve uzun zincirli yağ asitlerinden müteşekkil nötral yağların oral yolla immünoreaktif insülin üzerine etkileri araştırıldı.
11 gönüllü kişiye kısa zincirli yağ asitlerini temsilen 35 g. tereyağı, sabah açlıkta, oral yolla verildi. 11 kişilik ikinci gönüllü grubuna aynı yol ve miktarda uzun zincirli yağ asitlerinden müteşekkil ayçiçeği yağı verildi.
3.5 saat süreyle muayyen aralıklarda, kanın İRİ, serbest yağ asitleri, trigliserid ve glukoz seviyeleri incelendi,
Fizyolojik şart ve miktarlarda oral yolla verilen kısa zincirli yağ asitlerinin normal şahıslarda plazma immunoreaktif insülin seviyelerini artırdığı, uzun zincirli yağ asitlerinin ise, aynı şart ve miktarda, plazma immunoreaktif insülin seviyesini etkilemediği gösterildi.

Keywords

yağ , yağ asidi , immunoloji

Effects Of Long And Short Chan ​​Fatty Acids On Immunoreactive Insulin Dynamics In Normal Subjects

https://izlik.org/JA47HN95BJ

Abstract

The effects of neutral fats consisting of short and long chain fatty acids on immunoreactive insulin were investigated orally in 22 healthy individuals of ideal weight and without diabetes.

11 volunteers were given 35 g of butter representing short chain fatty acids orally in the morning, fasting. The second group of 11 volunteers was given sunflower oil consisting of long chain fatty acids by the same route and amount.
Blood IRI, free fatty acids, triglyceride and glucose levels were examined at certain intervals for 3.5 hours.

It was shown that short chain fatty acids given orally under physiological conditions and amounts increased plasma immunoreactive insulin levels in normal individuals, while long chain fatty acids, under the same conditions and amounts, did not affect plasma immunoreactive insulin levels.

Keywords

fat , fatty acid , immunology

References

• 1 Montaque, W. , Taylor, K. W. : Regulation of insulin secretion by short chain fatty acids. Nature (London), 217:853, 1968.
• 2 Seyffert, W. A. , Madison, L. L. : Acute Effect of Elevation of Plasma Free Fatty Acids on Hepatic Glucose Output, Peripheral Glucose Utilizax. tion, Serum insulin and Plasma Glucagon Levels. Diabetes. 16:763. 1967.
• 3 Nikkila, E. A. : Control of plasma and liver triglyceride kinetics by carbohydrate metabolism and insulin. Adv. Lipid Res. 7:63, 1969.
• 4 Barter, P. J. , Carrol, K. F., and Nestel, P. J. : Diurmal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man, J. Clin. invest. 50:583, 1971. 5 Yelow, R. S. , and Berson, S. A. : Ïmm_unoassay of endogenous plasma insulin in man. J. Clin. Invest., 39: 1157, 1960.
• 6 Hales, C. N., and Randle, p. J. : Double Antibody Method. Lancet. 1:200, 1963.
• 7 Sussman, K. E. , George, R. H. : metabolic control of insulin secretion. Acta Diabet. Lat. 7:889, 1970.
• 8 GrodSky, G. M., Butts, A. A., Bennet, L. L., Vicelle, C., Williams, N. B. and Smith, D. F. : Effects of Carbon hydrates on secretion of Însulin from isolated rat pancreas. Amer. J. Physiol. 205:638, 1963.
• 9 Pozza, G., Galansino, G. , Hoffeld, H., Foa, P. P. : Stimulation of insulin output by monosaccarides. Amer. J. Physiol. 192 :497, 1958.
• 10 Floyd, J. C., Fajans„ S. S., Conn, J. W. Knopl., R. F. and Bull, J. : lnsulin secretion in response to a protein jngestion, J. Clin. Invest 45: 1479, 1966.
• 11 - Fajans, S. S. , Knopl, R. F., Floyd, J. C., Power, C. J. W. : The experimental induction in man of sensitivity to leucine poglycemia. J. Clin. Invest. 42:2.16, 1963.
• 12 Fajans, S. S., Floyd, J. C., Pek., S., Knolp, R. F. Mitchell, J. and Conn, J. W. : Effect of protein meals on plasma insulin in midly diabetic patients. Diabetes. 18:523, 1969.
• 13 Laudicina, E. , Bompiani, G. , Angeleri, G. : Serum insulin levels in normal (obese and monobese) and diabetic subject after intragastric amino- acid load. Act. Diabet. Lat. 5:64, 1968.
• 14 I-iertelendy, F., Machlin, L. , Kipnis, D. M. : Further studies on the regulation of insulin and growth hormone secretion in sheep. Endocrinology, 84:192, 1969.
• 15 Carrol, F. K., Nestel, P. J. : Effect of Longchain Triglyceride on Human insulin Secretion Diabetes. 21:923, 1972.
• 16 Pisunyer, F . X ., Hasmin, S. A., and van Italiie, T. B. : Insulin and ketone responses to ingestion of medium and long-chain triglyceride in man. Diabetes. 18:96, 1969.
• 17 Arquilla, P. , and Stavitsky, A. B. : rl'he production and identification of antibodies to insulin and their use in assaying insulin. J. Clin. Invest. 35:458, 1956.
• 18 Yelow, R. S., and Berson, S. A. : Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39: 1157, 1960.
• 19 Hales, C. N., and Randle, P. J, : Double Antibody Iv3.-ethod.. Lancet. 1:200, 1963.
• 20 The Radio Chemical Centre, Tecnical Bulletein 68/6.
• 21 Dole, V. P. : Determination of treglycerides in plasma. J. Olin. Invest. 35:150, 1956.
• 22 Van Hardel, n. X., Silversmit, D. .13. : Micro method for the determination of serum Triglycerids. J. of Lab. Clin. and Mede 50/1¾ 152, 1957.
• 23 Manns, J. Boda, J. M. : Insulin release by acetate, propionate, Butyrate and glucose in lambs and adult sheep. Amer. J. Physiol. 212: 756, 1967.
• 24 - Wilson, D. E. , Screibman, P. H'. , Bl'ewstey•. A. G. and Arky, R. A. : The enhancement of alimentary lipe•mia by effl•žanol in man. J. Lab. Clin. Med. 75:264, 1970.
• 25 Schalch, D. S. , and Kipn.is, D. IVI. : Abnormalities in carbohydrate telerance assosieted with elevated plasma nonesterified fatty acids. J. Clin. Invest. 44:2010, 1965.
• 26 — Martin, M. J. : Factors Controlling insulin in vitro. Acta Diabet. Lat. 7:689, 1969.
• 27 - Unger, R. H. , Ketterer, H. 5 Dupre. J., and Eisentraut, A. M. : The effect of secretj.n, pancreozymin and gastrin on insulin and gû.ucagon secretion in anaesthetized dogs. J. Clin. Invest. 46:630, 1967.
• 28 Young, J. D. , Lazarus, L. , and Chisholm, l). J. : Radioirnmunoassay of pancreozymin - cholecystokinin in human serum. J. Nucl. Med. 10 : 743, 1969.
• 29 Feldman, M. J., and Lebowetz H. E. : Effect of fasting on insulin secra.tion and action in mice. Endocrinology, 86:313, 1970.
• 30 Neptun, E. M. : Chages as blood glucose during metabolism of B-hydroxy butyrate, Amer. J. Physiol. 187 :451, 1963.
• 31 Rarnes, R. A., Druny, D. R., Gecly, P. 0., and A. N. : Utilisation of ketone bodies in normal animals and in those with ketosis. Am. J. Phsiol. 18:451, 1953.
• 32 Gordon, R. S. , and Cherkes, A. , and Gater, H. : Unesterified fath.y acides in human blood plasma. ll. The transport function of unesterified fathy acides. J. Clin. Inves. 36:810, 1957.