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Pregnancy and Toxoplasmosis

Year 2018, Volume: 71 Issue: 1, 17 - 22, 16.10.2018

Abstract

Toxoplasma gondii is one of the major zoonotic parasitic infections that usually causes asymptomatic infections in humans but can cause signifcant disease in congenitally infected infants. Special care is taken to determine whether the infection was acquired before or after conception. Although rare, congenital toxoplasmosis can cause severe neurological or ocular disease, as well as cardiac and cerebral anomalies. The risk of fetal transmission of T. gondi infection which is acquired during gestation is effected by gestational age and treatment. Education of pregnant women about prevention of toxoplasmosis is very important. The purpose of this review is to provide an update on the diagnosis, treatment and management of toxoplasmosis during pregnancy

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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References

  • 1. Çolak H, Özgüneş İ. Gebelik, doğum ve abortusla ilgili enfeksiyonlar. Topçu AW, Söylenir G, Doğanay M editörler. Enfeksiyon Hastalıkları ve Mikrobiyolojisi. 3. Baskı. Ankara: Nobel Tıp Kitapevleri; 2008 (s 1528-1540)
  • 2. T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Kadın ve Üreme Sağlığı Daire Başkanlığı, Doğum Öncesi Bakım Yönetim Rehberi, 2014
  • 3. Remington JS, Thulliez P, Montoya JG. Recent developments for diagnosis of toxoplasmosis. J Clin Microbiol. 2004; 42(3): 941–945
  • 4. Mumcuoğlu İ, Toyran A, Çetin F ve ark. Gebelerde toksoplazmoz seroprevalansının değerlendirilmesi ve bir tanı algoritmasının oluşturulması. Mikrobiyol Bul. 2014; 48(2):283-291
  • 5. Negero J, Yohannes M, Woldemicheal K ve et al. Seroprevalence and potential risk factors of T. gondii infection in pregnant women attending antenatal care at Bonga Hospital, Southwestern Ethiopia. Int J of Infect Dis. 2017;57:44-49
  • 6. Torgerson PR, Mastroiacovo P. The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ. 2013;91:501–508
  • 7. Ertug S, Okyay P, Turkmen M. ve ark. Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey. BMC Public Health 2005; 5: 66.
  • 8. Tekay F, Ozbek E. The seroprevalence of Toxoplasma gondii in women from Sanliurfa, a province with a high raw meatball consumption. Turkiye Parazitol Derg 2007; 31(3): 176-179.
  • 9. Ocak S, Zeteroglu S, Ozer C ve ark. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 2007; 39(3): 231-234.
  • 10. Tamer GS, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med 2009; 32(1): E43-47.
  • 11. Çekin Y, Kızılateş F, Gür N ve ark. Investigation of Toxoplasma gondii seropositivity in pregnant women attending the Antalya Training and Research Hospital for the last four years. Turkiye Parazitol Derg 2011; 35(4): 181-184.
  • 12. Aral Akarsu G, Elhan HA, Akarsu C. Retrospective evaluation of Toxoplasma gondii seropositivity in fertile and infertile women. Mikrobiyol Bul 2011; 45(1): 174-180.
  • 13. Doğan K, Kafkaslı A, Karaman ve ark. The rates of seropositivity and seroconversion of toxoplasma infection in pregnant women. Mikrobiyol Bul 2012; 46(2): 290-294
  • 14. Frimpong C, Makasa M, Sitali L et al. Seroprevalence and determinants of toxoplasmosis in pregnant women attending antenatal clinic at the university teaching hospital, Lusaka, Zambia. BMC Infect Dis. 2017;17:10
  • 15. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans Int J Parasitol. 2000; 30(12-13): 1217– 1258.
  • 16. Montoya JG, Boothroyd JC, Kovacs JA. Toxoplasma gondi. In Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier Saunders; 2015 (p 3122-3153)
  • 17. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004;363(9425):1965-1976
  • 18. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008: 47(4):554- 566
  • 19. Dunn D, Wallon M, Peyron F et al. Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet 1999; 353:1829–1833
  • 20. National Committee for Clinical Laboratory Standard. Clinical use and interpretation of serologic tests for Toxoplasma gondii. Approved guideline M36-A. Wayne, PA: NCCLS, 2004.
  • 21. Romand S.Wallon M, Franck J et al. Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol. 2001;97(2):296-300
  • 22. Prusa AR.Kasper DC, Pollak A et al. Amniocentesis for the detection of congenital toxoplasmosis: results from the nationwide Austrian prenatal screening program. Clin Microbiol Infect 2015;21(2):191.e1-8
  • 23. De Oliveira Azevedo CT, do Brasil PE, Guida L et al. Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-Analysis. PLoS One. 2016;7:11(4)
  • 24. Villard O, Cimon B, L’Ollivier C et al. Serological diagnosis of Toxoplasma gondii infection; Recommendations from the French National Reference Center for Toxoplasmosis . Diagnostic Mıcrobiol and Infect Disese 2016;84:22-33
  • 25. Dard C, Fricker-Hidalgo H, Brenier-Pinchart MP et al. Relevance of and new developments in serology for toxoplasmosis. Trends Parasitol. 2016; 32(6):492-506
  • 26. Villard O, Breit L, Cimon B et al. Comparison of four commercially available avidity tests for Toxoplasma gondii-specific IgG antibodies. Clin Vaccine Immunol. 2013;20(2)197-204
  • 27. Sensini A. Toxoplasma gondii infection in pregnancy: opportunities and pitfalls of serological diagnosis. Clin Microbiol Infect. 2006;12(6)504-12
  • 28. Zhang K, Lin G, Han Y et al. Serological diagnosis of toxoplasmosis and standardization. Clin Chim Acta. 2016;461:83-89
  • 29. Boyer KM, Holfels E, Roizen N et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol 2005; 192:564–571.
  • 30. Pomares C, Montoya JG. Laboratory diagnosis of congenital toxoplasmosis. J Clin Microbiol. 2016;54(10)2448-2455
  • 31. Avelino MM, Amaral WN, Rodriques IM et al. Congenital toxoplasmosis and prenatal care state programs. BMC Infect Dis. 2014;14:33
  • 32. Wallon M, Peyron F, Cornu C et al. Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years. Clin Infect Dis. 2013;59(6):1223-31
  • 33. Prusa AR, Kasper DC, Pollak A et al. The Austrian Toxoplasmosis Register, 1992- 2008. Clin Infect Dis. 2015;60(2) :e4-e10
  • 34. Paquet C, Yudin MH, Society of Obstetricians and Gynaecologists of Canada. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. 2013;35(1):78-81
  • 35. Hotop A, Hlobil H, Gross U. Efficacy of rapid treatment initiation following primary Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2012;54(11):1545-1552
  • 36. Foulon W, Naessens A, Lauwers S et al. Impact of primary prevention on the incidence of toxoplasmosis during pregnancy. Obstet Gynecol. 1998;72:363-366
  • 37. Baril L, Ancelle T, Goulet V et al. Risk factors for toxoplasma infection in pregnancy:a case-control study in France, Scand J Infect Dis.1999;31:305-309
  • 38. Gollub EL, Leroy V, Gilbert R et al. Effectiveness of health education on toxoplasma-related knowledge, behaviour and risk of seroconversion in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2008;136:137-145

Gebelik ve Toksoplazmoz

Year 2018, Volume: 71 Issue: 1, 17 - 22, 16.10.2018

Abstract

Toxoplasma gondii major zoonotik paraziter enfeksiyonlardan biri olup insanda genellikle asemptomatik olarak seyretmektedir, fakat konjenital enfekte olan yenidoğanlarda ciddi klinik tablolara neden olabilir. Enfeksiyonun konsepsiyon öncesinde ya da sonrasında edinilmiș olmasının belirlenmesi oldukça önemlidir. Nadir olmasına rağmen konjenital toksoplazmoz ciddi nörolojik ya da oküler hastalıklara, aynı zamanda kardiyak ve serebral anomalilere neden olabilmektedir. Gebelik döneminde kazanılan T. gondii enfeksiyonlarının fetüse geçiș riski gestasyonel yaș ve tedaviye göre değișkenlik göstermektedir. Gebelerin toksoplazma enfeksiyonunun
önlenmesi konusunda bilgilendirilmesi oldukça önemlidir. Bu derlemede gebelik sırasında kazanılan toksoplazma enfeksiyonlarının tanısı, tedavisi ve yönetimi ile ilgili güncel bilgiler sunulmaktadır

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

References

  • 1. Çolak H, Özgüneş İ. Gebelik, doğum ve abortusla ilgili enfeksiyonlar. Topçu AW, Söylenir G, Doğanay M editörler. Enfeksiyon Hastalıkları ve Mikrobiyolojisi. 3. Baskı. Ankara: Nobel Tıp Kitapevleri; 2008 (s 1528-1540)
  • 2. T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Kadın ve Üreme Sağlığı Daire Başkanlığı, Doğum Öncesi Bakım Yönetim Rehberi, 2014
  • 3. Remington JS, Thulliez P, Montoya JG. Recent developments for diagnosis of toxoplasmosis. J Clin Microbiol. 2004; 42(3): 941–945
  • 4. Mumcuoğlu İ, Toyran A, Çetin F ve ark. Gebelerde toksoplazmoz seroprevalansının değerlendirilmesi ve bir tanı algoritmasının oluşturulması. Mikrobiyol Bul. 2014; 48(2):283-291
  • 5. Negero J, Yohannes M, Woldemicheal K ve et al. Seroprevalence and potential risk factors of T. gondii infection in pregnant women attending antenatal care at Bonga Hospital, Southwestern Ethiopia. Int J of Infect Dis. 2017;57:44-49
  • 6. Torgerson PR, Mastroiacovo P. The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ. 2013;91:501–508
  • 7. Ertug S, Okyay P, Turkmen M. ve ark. Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey. BMC Public Health 2005; 5: 66.
  • 8. Tekay F, Ozbek E. The seroprevalence of Toxoplasma gondii in women from Sanliurfa, a province with a high raw meatball consumption. Turkiye Parazitol Derg 2007; 31(3): 176-179.
  • 9. Ocak S, Zeteroglu S, Ozer C ve ark. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 2007; 39(3): 231-234.
  • 10. Tamer GS, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med 2009; 32(1): E43-47.
  • 11. Çekin Y, Kızılateş F, Gür N ve ark. Investigation of Toxoplasma gondii seropositivity in pregnant women attending the Antalya Training and Research Hospital for the last four years. Turkiye Parazitol Derg 2011; 35(4): 181-184.
  • 12. Aral Akarsu G, Elhan HA, Akarsu C. Retrospective evaluation of Toxoplasma gondii seropositivity in fertile and infertile women. Mikrobiyol Bul 2011; 45(1): 174-180.
  • 13. Doğan K, Kafkaslı A, Karaman ve ark. The rates of seropositivity and seroconversion of toxoplasma infection in pregnant women. Mikrobiyol Bul 2012; 46(2): 290-294
  • 14. Frimpong C, Makasa M, Sitali L et al. Seroprevalence and determinants of toxoplasmosis in pregnant women attending antenatal clinic at the university teaching hospital, Lusaka, Zambia. BMC Infect Dis. 2017;17:10
  • 15. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans Int J Parasitol. 2000; 30(12-13): 1217– 1258.
  • 16. Montoya JG, Boothroyd JC, Kovacs JA. Toxoplasma gondi. In Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier Saunders; 2015 (p 3122-3153)
  • 17. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004;363(9425):1965-1976
  • 18. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008: 47(4):554- 566
  • 19. Dunn D, Wallon M, Peyron F et al. Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet 1999; 353:1829–1833
  • 20. National Committee for Clinical Laboratory Standard. Clinical use and interpretation of serologic tests for Toxoplasma gondii. Approved guideline M36-A. Wayne, PA: NCCLS, 2004.
  • 21. Romand S.Wallon M, Franck J et al. Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol. 2001;97(2):296-300
  • 22. Prusa AR.Kasper DC, Pollak A et al. Amniocentesis for the detection of congenital toxoplasmosis: results from the nationwide Austrian prenatal screening program. Clin Microbiol Infect 2015;21(2):191.e1-8
  • 23. De Oliveira Azevedo CT, do Brasil PE, Guida L et al. Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-Analysis. PLoS One. 2016;7:11(4)
  • 24. Villard O, Cimon B, L’Ollivier C et al. Serological diagnosis of Toxoplasma gondii infection; Recommendations from the French National Reference Center for Toxoplasmosis . Diagnostic Mıcrobiol and Infect Disese 2016;84:22-33
  • 25. Dard C, Fricker-Hidalgo H, Brenier-Pinchart MP et al. Relevance of and new developments in serology for toxoplasmosis. Trends Parasitol. 2016; 32(6):492-506
  • 26. Villard O, Breit L, Cimon B et al. Comparison of four commercially available avidity tests for Toxoplasma gondii-specific IgG antibodies. Clin Vaccine Immunol. 2013;20(2)197-204
  • 27. Sensini A. Toxoplasma gondii infection in pregnancy: opportunities and pitfalls of serological diagnosis. Clin Microbiol Infect. 2006;12(6)504-12
  • 28. Zhang K, Lin G, Han Y et al. Serological diagnosis of toxoplasmosis and standardization. Clin Chim Acta. 2016;461:83-89
  • 29. Boyer KM, Holfels E, Roizen N et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol 2005; 192:564–571.
  • 30. Pomares C, Montoya JG. Laboratory diagnosis of congenital toxoplasmosis. J Clin Microbiol. 2016;54(10)2448-2455
  • 31. Avelino MM, Amaral WN, Rodriques IM et al. Congenital toxoplasmosis and prenatal care state programs. BMC Infect Dis. 2014;14:33
  • 32. Wallon M, Peyron F, Cornu C et al. Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years. Clin Infect Dis. 2013;59(6):1223-31
  • 33. Prusa AR, Kasper DC, Pollak A et al. The Austrian Toxoplasmosis Register, 1992- 2008. Clin Infect Dis. 2015;60(2) :e4-e10
  • 34. Paquet C, Yudin MH, Society of Obstetricians and Gynaecologists of Canada. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. 2013;35(1):78-81
  • 35. Hotop A, Hlobil H, Gross U. Efficacy of rapid treatment initiation following primary Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2012;54(11):1545-1552
  • 36. Foulon W, Naessens A, Lauwers S et al. Impact of primary prevention on the incidence of toxoplasmosis during pregnancy. Obstet Gynecol. 1998;72:363-366
  • 37. Baril L, Ancelle T, Goulet V et al. Risk factors for toxoplasma infection in pregnancy:a case-control study in France, Scand J Infect Dis.1999;31:305-309
  • 38. Gollub EL, Leroy V, Gilbert R et al. Effectiveness of health education on toxoplasma-related knowledge, behaviour and risk of seroconversion in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2008;136:137-145
There are 38 citations in total.

Details

Primary Language English
Subjects Medical Infection Agents
Journal Section Articles
Authors

Elif Mukime Sarıcaoğlu

Project Number -
Publication Date October 16, 2018
Published in Issue Year 2018 Volume: 71 Issue: 1

Cite

APA Sarıcaoğlu, E. M. (2018). Pregnancy and Toxoplasmosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 71(1), 17-22.
AMA Sarıcaoğlu EM. Pregnancy and Toxoplasmosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası. October 2018;71(1):17-22.
Chicago Sarıcaoğlu, Elif Mukime. “Pregnancy and Toxoplasmosis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71, no. 1 (October 2018): 17-22.
EndNote Sarıcaoğlu EM (October 1, 2018) Pregnancy and Toxoplasmosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 1 17–22.
IEEE E. M. Sarıcaoğlu, “Pregnancy and Toxoplasmosis”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 1, pp. 17–22, 2018.
ISNAD Sarıcaoğlu, Elif Mukime. “Pregnancy and Toxoplasmosis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71/1 (October2018), 17-22.
JAMA Sarıcaoğlu EM. Pregnancy and Toxoplasmosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71:17–22.
MLA Sarıcaoğlu, Elif Mukime. “Pregnancy and Toxoplasmosis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 1, 2018, pp. 17-22.
Vancouver Sarıcaoğlu EM. Pregnancy and Toxoplasmosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71(1):17-22.