Kronik Spontan Ürtikerde Siklosporin Tedavisi İle İlgili Gözlemlerimiz

Year 2016, Volume: 69 Issue: 2, 107 - 110, 20.10.2016

Hilayda Karakök , Seçil Saral Ayșenur Maden Nihal Kundakçı Beyza Doğanay Erdoğan , Bengü Nisa Akay

Abstract

Aim: Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigateefficacy and safety of cyclosporine in patients with chronic urticaria.
Material and Method: Twenty patients with chronic spontaneous urticaria whom detailed physical examinationwere noted and were treated in our center between 2005 and 2013 were included in this study

Results: A total 20 patients were included in this study. Daily wheal number and number of angioedema attackshad been compared and significant reduce in both parameters were detected. Total duration of treatmentwas mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were(min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two patientsunder treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 patient. We observed elevated creatinine levels in 3 patients.

Conclusion: A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticariafor a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy.

Keywords

Chronic Urticaria , Cyclosporine , urticaria

Supporting Institution

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Project Number

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Thanks

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Kronik Spontan Ürtikerde Siklosporin Tedavisi İle İlgili Gözlemlerimiz

Abstract

Amaç: Șiddetli seyreden kronik spontan ürtiker vakalarının tedavisi güçtür. Bu çalıșmada kronik ürtikertedavisinde siklosporinin etkinlik ve güvenilirliğini ölçmeyi hedefledik.

Materyal-Metod: 2005-2016 seneleri arasında kliniğimizde tetkik ve tedavi edilen ve ayrıntılı fizik muayenebulguları not edilen 20 kronik spontan ürtiker tanılı hasta çalıșmaya dâhil edildi.

Bulgular: Çalıșmaya toplam 20 hasta dâhil edildi. Günlük ürtika plağı sayısı ve anjioödem atağı sayısı karșılaștırıldıve her iki parametrenin de anlamlı azalma tespit edildi. Tedavinin toplam süresi 27,05 hafta (min: 4,maks:144, ±30,9507) idi. Günlük siklosporin dozları ortalama 2,2672 mg (min:0,54, maks:3,57 mg) idi. Tedavialtında iki hastada hafif hipertansiyon geliști ve antihipertansif ajanlarla etkili bir șekilde tedavi edildi. Birhastad diplopi geliști. Üç hastada kreatinin seviyelerinde yükselme tespit edildi.

Sonuç: Kronik ürtiker tedavisinde, 27 hafta süre ile günlük ortalama 2,2672 mg siklosporin kullanmanın etkiliolduğu tespit edilmiștir. Yan etki gelișimi açısından tüm hastalar takipte tutulmalıdır. Tedavi kesildikten sonra nüks ortalama 9 hafta sonra gelișmiștir.

Keywords

Kronik Ürtiker Ürtiker , Siklsoporin , ürtiker

Project Number

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