Abstract
1. Türkiyede ilk defa neşredilmiş olduğu zannedilen akut bir
promiyelositer lösemi vak'ası takdim olundu.
2. Akut promiyelositer löseminin literatürde önceleri akut
miyeloit lösemi, sonraları bizzat akut promiyelositer lösemi adı ile
yayınlanmış olan bir kısım vak'aları özellikleri ile özet olarak bhildirildi.
3. Akut promiyelositer lösemiyi karakterize eden ve promiyelosit
adı verilen hücrelerin özelliklerine işaret edildi. Bu tip lösemideki
fibrinojen değişikliklerinin mahiyeti ve hemorajik belirtilerin
sebebleri münakaşa edildi. Fibrinojenopeninin bu hastalıkta sabit
bir bulgu teşkil ettiği ve bunun trombositopeni ile bir arada kanama
diyatezinin husulünde sorumlu olduğu kanaatı ortaya konuldu
References
- 1. Tagnon, H. J.: The occurrence of fibrinolysis in shock, with observations on the prothrombin time and plasma fibrinogen during hemorrhagic shock. Am. J. M. Sc. 211:88, 1946.
- 2. Giraud, G., Gazal, P., Latour, H., Izorn, P., Levy, A., Bargon, P. and Ribstein, M.: Syndrome hemorrhagic mortal par fibrinolysé alguë au cours d’une loucose. Sang 25:628, 1954.
- 3 .Pisciotta, A. V. and Schulz, E. J.: Fibrinolytic purpura in acute leukemia. Am. J. Med. 19:824, 1955.
- 4. Cooperberg, A. A. and Neiman, G. M.: Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia. Ann. Int. Med. 42:706, 1955.
- 5. Hillestad, L. K.: Acute promyelocytic leukemia. Acta med. Scandinav. 159:189, 1957.
- 6. Bernard, J., Mathé, G., Boulay, J., Céoard, B., Chome, J.: La leucose alguë à promyélocytes, Schweiz, med. Wschr. 89:604, 1959.
- 7. Ghitis, J.: Acute promyelocytic leukemia? Blood 21:237, 1963.
- 8. Rosenthal, R. L.: Acute promyelocytic leukemia associated with hypofibrinogenemia. Blood 21:495, 1963.
- 9. Stefanini, M.: Fibrinolysis and fibrinolytic purpura. Blood 7:1044, 1952.
- 10. Risak, E.: Die Fibrinopenie, Ztschr. Kiln. Med. 128:605, 1935.
Abstract
1. A case of acute promyelocytic leukemia, believed to be the first to be published in Türkiye, was presented.
2. A number of cases of acute promyelocytic leukemia, initially published in the literature as acute myeloid leukemia and later as acute promyelocytic leukemia itself, were summarized.
3. The characteristics of the cells called promyelocytes, which characterize acute promyelocytic leukemia, were pointed out. The nature of fibrinogen changes and the causes of hemorrhagic manifestations in this type of leukemia were discussed. It was concluded that fibrinogenopenia is a consistent finding in this disease and that it is responsible for the bleeding diathesis associated with thrombocytopenia.
Keywords
Acute promyelocytic leukemia hypofibrinogenemia thrombocytopenia hemorrhagic diathesis fibrinolysis
References
- 1. Tagnon, H. J.: The occurrence of fibrinolysis in shock, with observations on the prothrombin time and plasma fibrinogen during hemorrhagic shock. Am. J. M. Sc. 211:88, 1946.
- 2. Giraud, G., Gazal, P., Latour, H., Izorn, P., Levy, A., Bargon, P. and Ribstein, M.: Syndrome hemorrhagic mortal par fibrinolysé alguë au cours d’une loucose. Sang 25:628, 1954.
- 3 .Pisciotta, A. V. and Schulz, E. J.: Fibrinolytic purpura in acute leukemia. Am. J. Med. 19:824, 1955.
- 4. Cooperberg, A. A. and Neiman, G. M.: Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia. Ann. Int. Med. 42:706, 1955.
- 5. Hillestad, L. K.: Acute promyelocytic leukemia. Acta med. Scandinav. 159:189, 1957.
- 6. Bernard, J., Mathé, G., Boulay, J., Céoard, B., Chome, J.: La leucose alguë à promyélocytes, Schweiz, med. Wschr. 89:604, 1959.
- 7. Ghitis, J.: Acute promyelocytic leukemia? Blood 21:237, 1963.
- 8. Rosenthal, R. L.: Acute promyelocytic leukemia associated with hypofibrinogenemia. Blood 21:495, 1963.
- 9. Stefanini, M.: Fibrinolysis and fibrinolytic purpura. Blood 7:1044, 1952.
- 10. Risak, E.: Die Fibrinopenie, Ztschr. Kiln. Med. 128:605, 1935.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 31, 1964 |
| Published in Issue | Year 1964 Volume: 17 Issue: 1 |