The comparison of clinical and cardiopulmonary effects of xylazine, medetomidine and detomidine in dogs

Abstract

This study intended to evaluate the effects of α2-adrenoceptor agonists (xylazine, medetomidine and detomidine) on clinical status and cardiopulmonary system in dogs. A total of 30 dogs were randomly assigned to 3 different groups. Following fasting period of 12 hours, xylazine (1 mg/kg IM), medetomidine (25 µ/kg IM) and detomidine (20 µg/kg IM) were administered to groups I, II and III, respectively. Body temperature, heart rates, and respiratory rates were recorded at predetermined times before and after injections. Serum electrolyte, biochemical parameters, blood gases were also evaluated in the blood samples before and after injection. ECG was recorded before, during and after sedation. Decrease in heart rate was found significant in all of the groups. Decrease in the respiration rate was statistically significant (P<0.001) for groups I and II, but not for group III. The decrease in body temperature was statistically significant (P<0.01) only in medetomidine group. Regarding to the biochemical parameters, the increase in blood glucose level was only statistically significant (P<0.05) in group I. Bradycardia, sinoatrial block, 2 Mobitz Type I, and 20 Mobitz Type II block were observed in all groups according to the ECG. Only in medetomidine group, heart rhythm disorders such as escape beat and escape rhythm were observed

Keywords

• Cardiopulmonary effect
• detomidine
• dog
• medetomidine
• xylazine

Köpeklerde xylazine, medetomidine ve detomidine’nin klinik ve kardiopulmoner etkilerininkarşılaştırılması

Abstract

Bu çalışmada, köpeklerde α2-adrenoreseptör agonistlerinin (xylazine, medetomidine ve detomidine) klinik ve kardiopulmoner sistem üzerindeki etkilerinin değerlendirilmesi amaçlandı. Toplam 30 adet köpek rastgele olarak 3 farklı gruba ayrıldı. 12 saatlik açlığı takiben I. gruptaki köpeklere xylazine (1 mg/kg İM), medetomidine (25 µg/kg İM), detomidine (20 µg/kg İM) dozunda uygulandı. Enjeksiyon öncesi ve sonrası belirli zaman beden ısısı, kalp atım ve solunum sayıları kaydedildi. Enjeksiyon öncesi ve sonrası alınan kan örneklerinde serum elektrolitleri, biyokimyasal parametreler ve kan gazları değerlendirildi. Sedasyon öncesi, sırası ve sonrası EKG kaydedildi. Kalp atım sayısındaki azalma bütün gruplarda anlamlı bulundu. Solunum sayısındaki azalma I. ve II. grupta anlamlı iken (P<0.001), III. grupta anlamlı değildi. Beden ısısında sadece medetomidine grubunda önemli azalma (P<0.01) belirlendi. Biyokimyasal parametrelerde sadece I. grupta glikoz değerinde artma istatiksel olarak anlamlı idi. Yapılan EKG değerlendirmelerinde bütün gruplarda bradikardi, sinoatrial blok, 2dereceMobitz Tip I, 2derece Mobitz Tip II bloklar görülürken, sadece medetomidine grubunda escape vuru, escape ritim gibi kalp ritm bozukluklarına rastlandı

Keywords

• Detomidine
• kardiyovasküler etki
• köpek
• medetomidine
• xylazine

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