Bir köpekte nekrolitik migratuar eritem

Abstract

Bu çalışmada octreotide tedavisinin başarıyla sonuçlandığı, sirozlu bir köpekteki Nekrolitik Migratuar Eritem (NME) olgusu sunulmaktadır. Derinin histopatolojik incelemesi NME’i göstermiştir. Kan parametreleri, karaciğer biyopsi sonucu, karaciğer ve pankreasın ultrasonografik ve bilgisayarlı tomografik incelemeleri şiddetli siroz varlığına işaret etmiş, bununla beraber pankreasta herhangi bir kitle ya da tümör bulunamamıştır. Hastada görülen deri hastalığının, sekonder hipergliseminin eşlik ettiği kronik hepatopati (siroz) sonucu oluştuğu düşünülmüştür. Octreotide, yüksek protein diyeti, yağ asitleri ve çinko kullanılmış ve böylelikle semptomlarda geçici bir düzelme sağlanmıştır. Sonunda karaciğer yetmezliğine bağlı nörolojik semptomlar, tekrarlanan kusma, kilo kaybı ve belirgin ağrı görülmüş ve hasta ötanazi edilmiştir. Deri, pankreas ve karaciğer dokularının makroskobik ve mikroskobik değerlendirmelerini kapsayan postmortem muayene sonuçları tanımızı doğrulamıştır

Keywords

• köpek
• Nekrolitik Migratuar Eritem

Necrolytic migratory erythema in a dog

Abstract

We report here a case of Necrolytic Migratory Erythema (NME) seen in a dog with cirrhosis in which octreotide therapy succeeded. Histopathologic examination of skin revealed NME. Blood parameters and liver cytology result, USG and CT examination of liver and pancreas indicated a severe cirrhosis, however any mass or tumor couldn’t be found on pancreas at the time. In this case, the skin disease was believed to be due to a chronic hepatopathy (cirrhosis) associated with secondary hyperglucagonemia. Octreotide, high level of protein diet, fatty acids and zinc supplement were used, and this provided temporary relief of signs. Neurologic symptoms related to liver failure, profuse vomiting, weight loss and apparent pain were eventually observed and the patient was euthanized. Postmortem examination including gross necropsy and microscobic evaluation of skin, liver and pancreas tissues confirmed our diagnosis

Keywords

• dog
• Necrolytic Migratory Erythema.

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