Dirofilaria immitis enfekte köpeklerde serum cystatinC konsantrasyonlarının değerlendirilmesi

Abstract

Glomerular filtrasyon hızının değerlendirilmesi amacı ile Dirofilaria immitis ile doğal enfekte köpeklerde yeni bir renal markır olan serum cystatinC (sCysC) konsantrasyonu kanin CysC ELISA kiti ile ölçüldü. Çalışmada yirmi mikrofilaremikseropozitif ve 20 amikrofilaremik-seronegatif köpek değerlendirildi. Her iki grupta serum üre ve kreatinin (sCre) konsantrasyonları ölçüldü. Enfekte köpeklerde ortalama sCysC konsantrasyonu 2.40 mg/L iken, kontrol grubunda 2.30 mg/L olarak bulundu. Enfekte köpeklerin ortalama serum üre konsantrasyonu 9.97 mmol/L, sCre 116.24 µmol/L bulunurken, kontrol grubunda değerler sırasıyla 11.92 mmol/L ve 128.62 µmol/L olarak tespit edildi. Gruplar arasında sCysC, sCre ile serum Urea:Cre oranları bakımından istatistiksel olarak farklılık bulunmadı. Diğer taraftan, serum üre konsantrasyonu gruplar arasında istatistiksel olarak farklı bulundu. Bu çalışma ile D. immitis ile enfekte köpeklerde sCysC konsantrasyonları değişmez gibi göründü

Keywords

• Dirofilaria immitis
• köpek
• serum cystatinC

Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis

Abstract

To assess glomerular filtration rate (GFR) in dogs naturally infected by D. immitis new renal marker serum cystatinC (sCysC) was measured with canine CysC ELISA kit. Twenty infected microfilaremic-seropositive and 20 amicrofilaremic and seronegative dogs evaluated in the study. Serum urea and creatinine (sCre) concentrations were measured in both groups. Mean sCysC concentrations in infected dogs were detected as 2.40 mg/L and 2.30 mg/L in controls. Mean serum urea 9.97 mmol/L and sCre 116.24 µmol/L concentrations in infected and in the uninfected group detected as 11.92 mmol/L and 128.62 µmol/L, respectively. Including mean sCysC and sCre concentrations with mean serum Urea:Cre ratio were not statistically differed between the groups. On the other hand, serum urea concentrations were statistically differed between groups. Based on the results of the present study, it is concluded that, sCysC concentrations seemed to be not altered in dogs with D. immitis infection

Keywords

• Dirofilaria immitis
• dog
• serum cystatinC

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