Novel of chronic phase of Canine Uveodermatologic Syndrome (Vogt- Koyanagi-Harada-like syndrome)

Abstract

The aim of the present study is to evaluate morphological findings of chronic uveodermatologic syndrome (UDS) in dogs. Five canine cases which had been diagnosed as chronic form of canine UDS pathologically were re-evaluated for histopathologically and immunohistochemically (CD3 and CD20). The dogs were from different breeds with the mean of 6-year-old (range 3 to 12 years) and enucleated globes were submitted from the different animal hospitals with the history of bilateral uveitis that was uncontrollable with anti-inflammatories, followed by glaucoma and blindness. Microscopically; mild to moderate lymphoplasmacytic uveitis together with histiocytic pigment phagocytosis, melanin containing macrophage infiltration and epithelial depigmentation were the main findings detected. Secondary glaucoma, synechia and iris bombé were also seen. The B lymphocytes were predominantly found in affected parts of the globe including iris, ciliary body, cilliary process and choroid. In conclusion, the chronic phase of canine uveodermatologic syndrome is characterized by mild to moderate lymphoplasmacytic uveitis or panuveitis. Although chronic form has not been reported in earlier canine reports, it is compatible with the chronic form of Vogt-KoyanagiHarada cases in humans

Keywords

• Chronic phase
• dog
• histopathology
• immunohistochemistry
• Uveodermatologic Syndrome
• Vogt-Koyanagi-Harada like Syndrome

Köpeklerin Uveodermatolojik Sendromunda (Vogt-Koyanagi-Harada Benzeri Sendrom) kronikdönem lezyonları

Abstract

Bu çalışmada köpeklerin uveodermatolojik sendromunun kronik formundaki morfolojik bulgular sunuldu. Daha önce patolojik olarak kronik Uveodermatolojik Sendrom (UDS) tanısı konmuş, ortalama 6 yaşında (3-12 yaş), 5 adet köpeğe ait 6 adet göz dokusu histopatolojik ve immünohistokimyasal (CD3 ve CD20) olarak incelendi. Enükle edilen gözler farklı hayvan hastanelerinden gönderilmiş olup, anemnez bulgusu olarak anti-inflamatuar ilaçlarla kontrol edilemeyen bilateral uveitis, glakom ve körlük bulguları mevcuttu. Hafif-orta şiddette uveitisle birlikte histiositik pigment fagositozu, melanin içeren makrofaj infiltrasyonu ve siliar epitelde depigmentasyon gözlenen belli başlı bulgulardı. Sekonder glakom, sineşi ve iris bombe bulgularına da rastlandı. Gözdeki incelenen yapılarda (iris, korpus siliare stroması, prosesus siliaris) B lenfositlerin baskın olarak bulunduğu ortaya kondu. Sonuç olarak, kronik dönem uveodermatolojik sendrom da hafif-orta şiddette uveitisle karakterizedir. Bu bulgu, daha önce köpeklerde bildirilmemiş olmakla birlikte insanlardaki kronik Vogt-Koyanagi-Harada sendromuyla uyumludur

Keywords

• Histopatoloji
• immunohistokimya
• köpek
• kronik dönem
• Uveodermatolojik Sendrom
• Vogt-Koyanagi

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