Concurrent metastatic hepatoid gland carcinoma and eosophagogastric leiomyosarcoma in a dog

Abstract

A 17-year-old male, mongrel dog was evaluated for a primary mass localized between perianal and sacral region and metastatic foci on lung. It was also encountered coincidentally with another mass taking place between distal esophagus and cardia of stomach and metastatic foci in kidney. In histopathological examination, perianal localization of mass and metastatic foci on lung were diagnosed as hepatoid gland carcinoma while esophagogastric mass and metastatic foci in kidney were diagnosed as leiomyosarcoma. In immunohistochemical examination, Ki-67 marker gave positive reaction in nuclei of anaplastic hepatoid gland cells in spite of vimentin and α-smooth actin positivity were found in reserve cells of the tumor. But, there was only positive with actin marker in leiomyosarcoma. It is considered useful to share results of the two different concurrent tumor in same dog

Keywords

• Dog
• hepatoid gland carcinoma
• leiomyosarcoma

Bir köpekte eş zamanlı metastatik hepatoid bez karsinomu ve özofagogastrik leiomyosarkom

Abstract

17 yaşlı erkek bir köpekte perianal ve sakral bölge arasında lokalize olan primer bir kitle ile akciğerdeki metastatik odaklar değerlendirildi. Rastlantısal olarak distal özefagus ve midenin kardiyası arasında yer alan diğer bir kitleyle birlikte böbrekte benzer odaklara rastlandı. Histopatolojik incelemede özefagogastrik yerleşimli ve böbrekte bulunan kitlelerin leiomyosarkom olarak tanılandırılmasına karşın, perianal bölgedeki kitle ile akciğerdeki metastatik odaklar hepatoid bez karsinomu olarak tanılandırıldı. İmmunohistokimyasal incelemede, vimentin ve α-smooth actin tümör rezerv hücrelerinde pozitif bulunmasına rağmen, Ki67 anaplastik hepatoid bez hücrelerinde pozitif reaksiyon verdi. Fakat leiomyosarkom sadece α-smooth actin ile pozitifti. Aynı köpekte iki farklı tümöre rastlanması açısından sonuçların paylaşılmasının yararlı olduğu düşünüldü

Keywords

• Hepatoid bez karsinomu
• köpek
• leiomyosarkom

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