Mezenkimal kök hücreler ve veteriner hekimlikte kullanımı

Abstract

Kök hücreler organizmada farklı hücre tiplerine dönüşebilen, canlı kaldıkça yaşamlarını sürdürme özelliğine sahip ve kendi kendilerini yenileyebilen hücrelerdir. Elde edildiği yere göre embriyonal ve yetişkin kök hücresi olmak üzere 2 tip kök hücre bulunmaktadır. Blastositin iç hücre kitlesinden elde edilen embriyonal kök hücreler tüm canlıyı oluşturabilirken differensiye olmuş bir dokudan elde edilen kök hücre sınırlı bölünme ve farklılaşma potansiyeline sahiptir. Embriyonal kök hücreler ile ilgili etik sınırlamalardan dolayı çalışmalar kısıtlıdır. Mezenkimal kök hücrelerdeki çalışmalar hem elde ediliş kolaylığı hem de rejeneratif tıpta kullanım alanı bulması ile öne çıkmaktadır. İnsanlarda kök hücre çalışmaları lokalize hastalıklarda, sistemik transplantasyonda, gen tedavisi ile kombine kök hücre tedavisinde ve doku mühendisliğinde olmak üzere dört alanda başlamıştır. Veteriner hekimlikte kök hücre çalışmaları insan hastalıklarına model oluşturması açısından deney hayvanlarında başlamıştır. Klinik olarak atlarda tendo yaralanmalarında köpeklerde ise osteoartiritisin/kıkırdak hasarının tedavisinde kullanım alanı bulmaktadır

Keywords

• Kemik iliği
• klinik uygulama
• kök hücre

Mesenchymal stem cells (Msc) and stem cell applications in veterinary medicine

Abstract

In the living organism stem cells differentiate into diverse specialized cell types, capable of sustaining viability and self-renewal. Stem cells can be categorized as embryonal, and adult due to its origin. Embryonic stem cells obtained from the inner cell mass of the blastocyst has the ability to create the whole organism, differentiated tissue-derived stem cells have the limited growth and differentiation potential and tend to turn into the tissue from which they originated. Due to ethical limitations studies in the embryonic stem cells are limited. Ease of obtaining and common use of the cells in regenerative medicine makes mesenchymal stem cells favorable for studies. In humans; localized disease, systemic transplantations, stem cell therapy in combination with gene therapy and tissue engineering are the four areas of work to be started on stem cells. Stem cell research in veterinary medicine started in experimental animals in terms of being a good model for human diseases. Clinically mesenchymal stem cells are broadly used in horses for tendon injuries and in dogs for osteoartiritis/ injury of the cartilage

Keywords

• Bone marrow
• clinical application
• stem cell

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