Prognostic usefulness of some parameters in dogs with canine parvovirus

Abstract

The purpose of this study was to evaluate the prognostic usefulness of some parameters in dogs with canine parvovirus (CPV). Fifty-nine animals which consist of 39 ill and 20 healthy puppies were used in the study. All puppies were underwent a complete physical examination and laboratory variables (CBC, serum routine biochemistry profile, cTn-I, TNF-α) on their first admission to clinic and on following every day before treatment until discharge or death. Despite aggressive treatment with available therapy, 14 of 39 dogs died. Non-survivor dogs had significantly lower leukocyte, lymphocyte, monocyte and granulocyte counts but had significantly higher serum urea and creatinine concentrations than those of survivor dogs at presentation (p<0.05). Serum cTn-I concentration level were positive in 11of 14 non-survival dogs and negative in all of the survival dogs. The relative risk of death for the dogs with TNF-α positive was 3,39 times (95% CI:1,53-7,52) higher than that of dogs with TNF-α negative. This study demonstrates that leukocyte, lymphocyte, granulocyte, monocyte counts, serum urea and creatinine concentrations, cTn-I and TNF-α levels are useful parameters for predicting the prognosis of dogs with CPV

Keywords

• Canine parvovirus
• cTn-I
• prognosis
• TNF-α

Kanin parvoviruslu köpeklerde bazı parametrelerin prognostik kullanımları

Abstract

Bu çalışmanın amacı kanin parvoviruslu köpeklerde (CPV) prognostik yararı olan bazı parametlerin değerlendirilmesidir. Bu çalışmada 39’u hasta, 20’si sağlıklı olmak üzere toplam 59 köpek kullanıldı. Bütün köpeklerin fiziksel muayene ve laboratuar (CBC, serum routine biochemistry profile, cTn-I, TNF-α) verileri kayıt altına alındı. Uygulanan agresif tedaviye rağmen 39 köpeğin 14’ü öldü. Ölen köpeklerde lökosit, lenfosit, monosit ve granülosit sayısı önemli derecede düşük; üre ve kreatinin konsantrasyonu ise iyileşen köpeklere oranla önemli derecede yüksek bulundu (p<0.05). Serum cTn-I konsantrasyonu, ölen 14 köpeğin 11’inde pozitif, iyileşen köpeklerin tamamında negatif bulundu. TNF-α pozitif olan köpeklerin ölme olasılığının iyileşenlere göre 3,39 kat daha fazla olduğu saptandı (95% CI:1,53-7,52). Bu çalışma; lökosit, lenfosit, granülosit, monosit sayılarının; serum üre ve kreatinin konsantrasyonlarının; cTn-I ve TNF-α değerlerinin, CPV’li köpeklerde prognozun belirlenmesinde önemli parametreler olduğunu gösterdi

Keywords

• cTn-I
• kanin parvovirus
• prognosis
• TNF-α

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