Mesothelioma in a dog

Abstract

In this study a mesothelioma case observed in a four–year-old female Rottweiler dog was defined. Macroscopically, on the serosal surfaces of the stomach and intestines, numerous masses showing diffuse distribution, greyish yellow in colour and hard consistency were observed. Microscopically, tumour cells were predominantly spindle-shaped with moderate amounts of eosinophilic cytoplasm and ovoid nuclei. These cells was not stained with epithelial membrane antigen (EMA) staining, the epithelial marker, while stained with the epithelial marker pancytokeratin and mesenchymal marker vimentin in the avidin-biotin-peroxidase (ABC-P) method. As a result, tumor case seen in a dog's stomach and intestinal serosal surface was defined as a mesothelioma according to the histopathological and immunohistochemical findings

Keywords

• Dog
• immunohistochemistry
• mesothelioma

Köpekte mezotelioma olgusu

Abstract

Bu çalışmada 4 yaşlı Rottweiler ırkı, dişi bir köpekte gözlenen mezotelioma olgusu tanımlandı. Makroskobik olarak mide ve bağırsakların serozal yüzeyinde diffuz dağılım gösteren, değişik büyüklükte ve sert kıvamda, grimsi sarı renkte kitleler görüldü. Mikroskobik olarak tümör hücreleri çoğunlukla iğ şeklinde, eozinofilik sitoplazmalı ovoid çekirdekliydi. Bu hücreler uygulanan avidin biyotin peroksidaz (ABC-P) immunohistokimyasal boyama yönteminde, epiteliyal belirteç pansitokeratin ve mezenkimal belirteç vimentin ile boyanırken epiteliyal belirteç olan epitheliyal membran antijeni (EMA) ile boyanmadı. Sonuç olarak bir köpeğin mide ve bağırsak serozal yüzeyinde karşılaşılan tümör olgusu, histopatolojik ve immunohistokimyasal bulgularına göre mesotelioma olarak tanımlandı

Keywords

• İmmunohistokimya
• köpek
• mezotelioma

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