The effect of chloramphenicol and florfenicol on electrocardiogram in guinea pigs

Abstract

In this study, the effects of chloramphenicol and florfenicol on electrocardiogram of guinea pigs were investigated. Single dose of 20 mg/kg of chloramphenicol intramuscular and 20 mg/kg of florfenicol have been applied to the groups orally at the same time every day for one week duration. After the results of electrocardiograms obtained were examined, it was determined that there has been an increase (p<0.01) in P wave amplitude with chloramphenicol application and there has been a shortening (p<0.001) in the duration of P wave compared to the control group for both test groups. It was observed that there has been a shortening (p<0.01) in the duration of P-R interval in the chloramphenicol applied group compared to the control group. When we had an evaluation between groups in terms of R wave amplitude, shortening (p<0.05) was observed in the group of which florphenicol was applied. Shortening has been observed in the duration of QRS complex (p<0.001), the duration of QT interval (p<0.001), QTc value (p<0.05) in the test groups compared to the control group, on the other hand an increase has been observed in the duration of T wave (p<0.05) and the number of heartbeat as minute (p<0.01). As a result, because these changes have been observed after the application of chloramphenicol and florfenicol on electrocardiogram, it has been reached to an opinion that these medications may cause adverse effects on cardiovascular system

Keywords

• ECG
• florfenicol
• chloramphenicol
• guinea pig
• adverse effect

Kobaylarda kloramfenikol ve florfenikol’ün elektrokardiyogram üzerine etkisi

Abstract

Çalışmada kobaylarda amfenikol grubundankloramfenikol ve florfenikolün elektrokardiyogram üzerine etkileri incelendi. Deney gruplarındaki hayvanlara bir hafta süre ile her gün aynı saatte tek doz 20 mg/kg kloramfenikol intramuskuler ve 20 mg/kg florfenikol oral yol ile uygulandı. Elde edilen elektrokardiyogramların incelenmesi sonrasında, P dalgası amplitüdünde kloramfenikol uygulamasıyla büyüme (p<0.01), P dalgasının süresinde her iki deney grubunda da kontrole göre kısalma (p<0.001) belirlendi. P-R aralığı süresinde kontrole oranla kloramfenikol uygulanan grupta kısalma (p<0.01) tespit edildi. R dalgasının amplitüdü açısından gruplar arasında değerlendirme yapıldığında kısalma (p<0.05) şeklindeki fark florfenikol uygulanan grupta belirlendi. QRS kompleksi süresi (p<0.001), QT aralığının süresi (p<0.001), QTc değerinde kontrole oranla deney gruplarına ait değerlerde kısalma (p<0.05), T dalgası süresi (p<0.05) ve dakika kalp atım sayısında ise artış (p<0.01) kaydedildi. Sonuç olarak, kloramfenikol ve florfenikol uygulanmasından sonra elektrokardiyogramda gözlenen değişiklikler bu iki ilacın kardiyovasküler sistemde istenmeyen etkilere neden olabileceği kanısını uyandırdı

Keywords

• EKG
• florfenikol
• kloramfenikol
• kobay
• yan etki

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