Immunohistochemical distribution of ghrelin positive cells in the abomasum of sheep

Abstract

Ghrelin is a novel 28-amino-acid-peptide isolated from the rat and human stomach. This peptide is predominantly produced by the stomach, in addition lower amounts derive from small and large intestines, pancreas, pituitary gland, kidney, placenta, immun system organs and cells, testis, ovary and arcuate nucleus of hypothalamus. In this study, distrubition of ghrelin immunoreactive cells in the abomasum of sheep was investigated. Tissue samples were taken from cardia, fundus , the proximal region of pylorus, main/distal pylorus regions of abomasum. The results have revealed that ghrelin immunopositive cells distrubuted throughout the mucosal layer of abomasum of sheep, in other mammalian species

Keywords

• Abomasum
• Ghrelin
• immunohistochemistry
• sheep

Koyun abomasumunda ghrelin pozitif hücrelerin immunohistokimyasal dağılımı

Abstract

Ghrelin rat ve insan midesinden izole edilen 28 amino asitli bir peptiddir. Bu peptid öncelikle mide tarafından üretilmektedir, ayrıca ince ve kalın barsaklardan, pankreas, hipofiz, böbrek, plasenta, immun sistem, testis, ovaryum ve hipotalamusun arkuat nukleusundan küçük miktarlarda elde edilmiştir. Çalışmamızda, koyun abomasumunda Ghrelin immun pozitif hücrelerin dağılımı incelendi. Abomasum cardia, fundus, proksimal ve distal pilorus olmak üzere 4 bölüme ayrılarak incelendi. Sonuç olarak, Ghrelin immunpozitif hücrelerin diğer memeli hayvanlarda olduğu gibi abomasumun mukozal katmanına dağıldığı görüldü

Keywords

• abomasum
• Ghrelin
• immunohistokimya
• koyun

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