Köpeklerde sevofluran, izofluran ve halotan anestezilerinin spontan ve kontrollü ventilasyonsırasındaki kardiyopulmoner etkileri

Abstract

Bu çalışma ile köpeklerde spontan ventilasyon (SV) ve kontrollü ventilasyon (CV) sırasında sevofluran (SEV), izofluran (ISO) ve halothan (HAL) anestezilerinin kardiyopulmoner etkilerinin incelenmesi amaçlandı. Çalışma deneysel olarak planlandı ve çalışmada 60 sağlıklı melez köpek kullanıldı. Köpekler eşit olacak şekilde rastgele 6 anestezi grubuna ayrıldı: SEV/SV; SEV/CV; ISO/SV; ISO/CV; HAL/SV; HAL/CV. Xylazine HCL ile premedikasyonu takiben indüksiyon thiopental sodium ile yapıldı ve SEV, ISO ve HAL ile 90 dakika boyunca inhalasyon anestezisi oluşturuldu. Kardiyopulmoner parametreler [kalp frekansı (HR), solunum sayısı (RR), ortalama arteriyel kan basıncı (MAP), solunum sonu karbondioksit düzeyi (ETCO2), oksijen saturasyonu (SpO2), sentral venöz basınç (CVP), beden ısısı, parsiyel arteriyel oksijen basıncı (PaO), parsiyel arteriyel karbondioksit basıncı (PaCO2) ve arteriyel pH] ölçüldü. İlk ölçüm değeri, inhalasyon anestezikleri ile bilincin kaybolmasından bir dakika sonra, diğer ölçüm değerleri ise 15., 30., 45. 60. ve 90. dakikalarda kaydedildi. HR’de anestezik maddeler arasında SV ve CV sırasında belirgin bir farklılık kaydedilmedi. SV’de ISO ve HAL anestezileri ile RR anlamlı şekilde azaldı (p<0.001). MAP tüm gruplarda belirgin olarak azaldı fakat ventilasyon modları arasında belirgin bir farklılık gözlenmedi. SV ile karşılaştırıldığında, CV sırasında ETCO2’deki azalma belirgindi (p<0.001). SEV anestezisi ile SV sırasında CVP değerleri daha düşük seyretti (p<0.001). Beden ısısı, ISO ve HAL anestezilerinde, SEV anestezisi ile karşılaştırıldığında anlamlı derecede düşüktü (p<0.001). CV, SV’ye göre PaCO2 artışını engelledi (p<0.001) ve pH’da düşme gözlenmedi (p<0.05). Xylazine HCL ile premedikasyon ve thiopental sodium ile indüksiyonu yapılmış sağlıklı köpeklerde, SEV ile oluşturulan genel anestezi sırasında kardiyopulmoner parametreler üzerinde minimal komplikasyon oluştuğu sonucuna varıldı. Çalışmada, inhalasyon anestezisi sırasında CV’nun kullanılması ile daha stabil bir anestezi sağlandı

Keywords

• Kontrollü ventilasyon
• köpek
• spontan ventilasyon
• volatil anestezik

The cardiopulmonary effects of sevoflurane, isoflurane and halothane anesthesia during spontaneous or controlled ventilation in dogs

Abstract

The objective of this study was to investigate the cardiopulmonary effects of sevoflurane (SEV), isoflurane (ISO) and halothane (HAL) anesthesia during spontaneous ventilation (SV) or controlled ventilation (CV) in dogs. An experimental study was designed. Sixty healthy cross breed dogs were used for the study. Dogs were randomly allocated to six anesthesia groups (n = 10 in each group): SEV/SV; SEV/CV; ISO/SV; ISO/CV; HAL/SV; HAL/CV. After premedication with xylazine HCl, anesthesia was induced with thiopental sodium. Inhalation anesthesia was maintained for 90 minutes with SEV, ISO, or HAL. Cardiopulmonary parameters [heart rate (HR), respiratory rate (RR), mean arterial blood pressure (MAP), end tidal carbon dioxide level (ETCO2), oxygen saturation (SpO2), central venous pressure (CVP), body temperature, arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and arterial pH] were measured after induction of anesthesia; the first measurement was taken one minute after the loss of consciousness with SEV, ISO, or HAL and the others were done at 15th, 30th, 45th, 60th and 90th minutes. There was not any significant difference in HR between anesthetics among SV and CV. RR decreased significantly during ISO and HAL anesthesia in SV (p<0.001). MAP decreased significantly in all groups but there was not any significant difference between the ventilation modes. There was a significant decrease in ETCO during CV compared to SV (p<0.001). The CVP values during anesthesia with SEV in SV were lower than those of other anesthetics (p<0.001). Body temperature decreased significantly during ISO and HAL anesthesia compared to SEV anesthesia (p<0.001). Compared with SV, CV prevented the increase in PaCO2(p<0.001) and no decrease in pH was observed (p<0.05). It is concluded that SEV anesthesia was appeared to have minimum complications on cardiopulmonary parameters in the healthy dogs which were premedicated with xylazine HCL and inducted with thiopental sodium. In the study, the use of CV was not associated with cardiovascular embarrassment during inhalation anesthesia and it was provide a more stable plane of anesthesia

Keywords

• Controlled ventilation
• dog
• spontaneous ventilation
• volatile anesthetics

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