Blood HbA1C levels in dogs with diabetes mellitus

Abstract

The phenomenon of glucose molecules binding to proteins by a nonenzymatic glycation mechanism are known as glycated hemoglobin which is directly related to the amount of blood glucose levels. The level of HbA1c are increased in hyperglicaemia. Glycated Hb is an index of the mean blood glucose concentration over the long period. This index is not effected from the glycemic fluctuations in a short period. Therefore, HbA1c can be a good sign for controlling the blood sugar in Diabetes mellitus. In veterinary medicine, hyperglicaemia can be seen in the stress conditions during the blood sample collection from cats and dogs. HbA1c level is not effected from hyperglycemia in stress conditions. In this study, blood glucose and HbA1c levels were analysed and compared with the control group levels for the evolutions of blood HbA1c levels in dogs withDiabetes mellitus. The blood serum glucose levels in dogs with Diabetes mellitus and the control dogs were found to be 526.71±22 mg/dl and 97.80±2.93 mg/dl respectively. Moreover blood HbA1c levels of diabetic and control dogs were found 3.11±0.4 % and 1.07±0.08 % respectively. The blood HbA1c levels in Diabetes mellitus group in comparison to control group were found to be statisticaly higher (p<0.01)

Keywords

• Diabetes mellitus
• dog
• glycosylated haemoglobin
• HbA1c

Diyabetli köpeklerde kan HbA1C düzeyleri

Abstract

Glikozun, proteinlere enzimatik olmayan bağlanması sonucu oluşan glikozile hemoglobinler büyük ölçüde kan glikoz derişimine bağlıdır; dolayısıyla hiperglisemide miktarları artar. Glikozile hemoglobinler, uzun bir süreç içindeki ortalama kan glikozu için bir gösterge oluşturur. Bu gösterge, kan şekerindeki kısa süreli dalgalanmalardan etkilenmez ve dolayısıyla diyabette kan şekeri kontrolünün nispeten daha doğru bir göstergesidir. Veteriner hekimliğinde, özellikle kedi ve köpeklerden kan alınması esnasında, strese bağlı hiperglisemiler görülebilmektedir. HbA1c düzeyleri ise, strese bağlı oluşabilen hiperglisemiden etkilenmemektedir. Bu çalışmada diyabetli köpeklerde kan HbA1c düzeylerinindeğerlendirilmesi amacıyla kan plazma glikozu ile kan HbA1c düzeyleri ölçülerek kontrol grubu değerleri ile karşılaştırılmıştır. Diyabetli ve kontrol grubu köpeklerde kan plazma glikoz değerleri sırasıyla 526.71±22 mg/dl, 97.80±2.93 mg/dl ölçülmüştür. HbA1C düzeyleri ise diyabetli grupta % 3.11±0.4 kontrol grupta % 1.07±0.08 bulunmuştur. Kan HbA1c ve glikozdüzeyleri diyabetli grupta kontrol grubuna göre istatistik olarak önemli derecede yüksek (p<0.01) bulunmuştur

Keywords

• Diyabet
• glikozile hemoglobin
• HbA1c
• köpek

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