The effect of amygdalin on electrocardiogram and blood nitric oxide levels in guinea pigs

Abstract

In this study the effects of amygdalin on electrocardiogram and blood nitric oxide (NO) levels in guinea pigs were investigated. 32 male, albino guinea-pigs were randomly assigned to one control and three experiment groups. One dose of 50 mg/kg, 100 mg/kg and 200 mg/kg amygdalin dissolved in distilled water were given to the second, third and fourth groups using gastric cathater. One hour after the drug administration, electrocardiography measurements were recorded and serum NO levels were determined. When the serum NO levels of the second, third, and fourth groups were compared to the serum NO level of the control group, each of the differences was found statistically significant (p

Keywords

• Amygdalin
• electrocardiogram
• guinea-pig
• nitric oxide

Kobaylarda amigdalinin elektrokardiyogram ve kan nitrik oksit düzeyine etkisi

Abstract

Araştırmada amigdalinin kobaylarda elektrokardiyogram ve kan nitrik oksit (NO) düzeyi üzerine etkileri incelendi. 32 kobay, bir kontrol ve geri kalan üç grup deney grupları olacak şekilde dört gruba ayrıldı ve 50 mg/kg, 100 mg/kg ve 200 mg/kg dozunda amigdalin tek doz, ağız yoluyla uygulandı. Uygulamayı takiben elektrokardiyografi çekimleri yapıldı ve serumda NO konsantrasyonları belirlendi. Serum NO miktarının kontrol grubuna göre sırasıyla 50 mg/kg, 100 mg/kg ve 200 mg/kg dozunda amigdalin uygulanan gruplarda istatistiksel olarak anlamlı bir şekilde arttığı (p

Keywords

• Amigdalin
• elektrokardiyogram
• kobay
• nitrik oksit

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