Ratlarda gentamisine bağlı oluşan nefrotoksisiteden korunmada allopurinolün etkisizliği

Abstract

Bu çalışmada, ksantin oksidaz inhibitörü olan allopurinolün gentamisin nefrotoksikozisinde koruyucu etkinliğinin araştırılması amaçlanmıştır.Gentamisin verilen grubun serum üre ve kreatinin düzeyleri ile plazma MDA düzeyi kontrol grubuna göre istatistiksel olarak önemli düzeyde yüksek bulunurken, eritrositlerde GSH-Px, SOD aktiviteleri düşük bulundu. Gentamisin+Allopurinol verilen grubun serum üre ve kreatinin düzeyleri ile plazma MDA düzeyi kontrol grubuna göre önemli düzeyde yüksek bulunurken, GSH-Px, SOD ve CAT aktiviteleri önemli düzeyde düşüktü. Gentamisin verilen grubun plazma MDA düzeyi gentamisin+allopurinol verilen gruba göre önemli düzeyde düşük iken GSH-Px, SOD aktiviteleri önemli düzeyde yüksekti. Sonuçta ksantin oksidaz inhibitörü olan allopurinolün gentamisin nefrotoksikozisinin oluşumunu önleyemediği kanısına varılmıştır

Keywords

• Allopurinol
• gentamisin
• nefrotoksikozis
• rat

Unable to protect gentamicin-induced nephrotoxicity with allopurinol in rats

Abstract

In this study, it is purposed to investigate the protective effects of allopurinol, a xanthine oxidase inhibitor, against gentamicin -induced nephrotoxicosis. The levels of serum urea, creatinine and plasma MDA were significantly higher and GSH-Px, SOD activities were lower in gentamicin administrated group than the control. The levels of serum urea, creatinine and plasma MDA were significantly higher and GSH-Px, SOD and CAT activities were significantly lower in gentamicin + allopurinol administrated group than the control. Plasma MDA was significantly lower and GSH-Px, SOD activities were higher in gentamicin induced group than gentamicin + allopurinol induced group. In conclusion, results demonstrate that allopurinol, a xanthine oxidase inhibitor, does not prevent the formation of gentamicin induced nephrotoxicosis

Keywords

• Allopurinol
• gentamicin
• nephrotoxicosis
• rat

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