The investigation of the effect of levamisole on rabbit trachea alone and combined with trichlorfon

Abstract

The aim of this study is to investigate the effect of levamisole on rabbit trachea, the antagonists of levamisole and reveal the relation between trichlorfon and levamisole. The cumulative concentrations of levamisole (10-8 - 10 M) were applied to the tracheal ring of rabbit. Bethanecole, carbachol, acetylcholine, trichlorfon, mecamylamine, atropine and nicotin were also studied with levamisole. Levamisole was without considerable effect alone on rabbit trachea. It was seen that the incubation with levamisole increased the Emax value of acetylcholine (p

Keywords

• Levamisole
• pharmacodynamic effect
• rabbit
• trachea
• trichlorfon

Tavşan trakeası üzerine levamizolun etkisinin tek başına ve triklorfonla birlikte araştırılması

Abstract

Bu araştırmada, levamizolun tavşan trakeası üzerine etkisini belirlemek, levamizolun antagonistlerini saptamak, levamizol ile triklorfon arasındaki ilişkiye açıklık kazandırmak amaçlandı. Levamizol (10-8-10-3 M) birikimli derişimlerde ve 5x10-5M derişimde asetilkolin (Ak), karbakol, betanekol, triklorfon, mekamilamin, nikotin ve atropin ile birlikte değişik terkip ve derişimlerde 82 tavşan trakeası üzerinde çalışıldı. Tavşan trakeası üzerine levamizolun tek başına etkisiz olduğu tespit edildi. Levamizol inkübasyonunun Ak’nın Emax değerini artırdığı (p

Keywords

• Farmakodinamik etki
• levamizol
• tavşan
• trakea
• triklorfon

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