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D Vitamini Eksikliği ve Obezite İlişkisi

Year 2023, , 50 - 56, 27.12.2022
https://doi.org/10.53493/avrasyasbd.1152750

Abstract

Obezite, günümüzün en yaygın sağlık sorunlarından olup tüm dünyayı etkilemektedir. Obezite, kardiyovasküler hastalıklar, kanser türleri, diyabet gibi birçok hastalık ile de ilişkili bulunmuştur. D vitamini, vücutta endojen olarak sentezlenen bir vitamin olup kemik dokusunun korunması, kalsiyum-fosfor homeostazının sağlanması gibi birçok görevde rol oynamaktadır. D vitamini eksikliği, güneş ışığına yeterince maruz kalmama, yetersiz beslenme gibi birçok faktöre bağlı olarak yaygın görülmektedir. D vitamini eksikliği kardiyovasküler hastalıklar, arteriyel hipertansiyon, dislipidemi, tip 2 diyabet, kanser, multipl skleroz, depresyon, demans, psikiyatrik hastalıklar ve diğerleri gibi çok sayıda bozuklukla ilişkilendirilmiştir. Obezitenin patogenezinde D vitamini eksikliğinin rolünü düşündüren çeşitli hipotezler gelişmiştir. Genel olarak çalışmalarda obezite ve serum D vitamini düzeyleri arasında ters bir ilişki olduğu bildirilmiştir.

References

  • Arterburn, D. E., & Courcoulas, A. P. (2014). Bariatric surgery for obesity and metabolic conditions in adults. Bmj, 349.
  • Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2014). Vitamin D status and ill health: a systematic review. The Lancet Diabetes & Endocrinology, 2(1), 76-89.
  • Bacopoulou, F., Kolias, E., Efthymiou, V., Antonopoulos, C. N., & Charmandari, E. (2017). Vitamin D predictors in polycystic ovary syndrome: a meta‐analysis. European Journal of Clinical Investigation, 47(10), 746-755.
  • Blumberg, J. M., Tzameli, I., Astapova, I., Lam, F. S., Flier, J. S., & Hollenberg, A. N. (2006). Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. Journal of Biological Chemistry, 281(16), 11205-11213.
  • Bolland, M. J., Grey, A. B., Ames, R. W., Mason, B. H., Horne, A. M., Gamble, G. D., & Reid, I. R. (2007). The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. The American Journal of Clinical Nutrition, 86(4), 959-964.
  • Bray, G. A. (2003). Evaluation of obesity: who are the obese?. Postgraduate Medicine, 114(6), 19-38.
  • Carrelli, A., Bucovsky, M., Horst, R., Cremers, S., Zhang, C., Bessler, M., & Stein, E. M. (2017). Vitamin D storage in adipose tissue of obese and normal weight women. Journal of Bone and Mineral Research, 32(2), 237-242.
  • Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism: Clinical and Experimental, 92, 6–10. https://doi.org/10.1016/j.metabol.2018.09.005
  • Ding, C., Gao, D., Wilding, J., Trayhurn, P., & Bing, C. (2012). Vitamin D signalling in adipose tissue. British Journal of Nutrition, 108(11), 1915-1923.
  • Drincic, A., Fuller, E., Heaney, R. P., & Armas, L. A. (2013). 25-Hydroxyvitamin D response to graded vitamin D3 supplementation among obese adults. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4845-4851.
  • DSÖ, 2010. https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi Erişim: 25.05.2022
  • Earthman, C. P., Beckman, L. M., Masodkar, K., & Sibley, S. D. (2012). The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. International Journal of Obesity, 36(3), 387-396.
  • Evans, A. L., Paggiosi, M. A., Eastell, R., & Walsh, J. S. (2015). Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. Journal of Bone and Mineral Research, 30(5), 920-928.
  • Gallagher, J. C., Yalamanchili, V., & Smith, L. M. (2013). The effect of vitamin D supplementation on serum 25OHD in thin and obese women. The Journal of Steroid Biochemistry and Molecular Biology, 136, 195-200.
  • Gangloff, A., Bergeron, J., Lemieux, I., & Després, J. P. (2016). Changes in circulating vitamin D levels with loss of adipose tissue. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 464-470.
  • Gletsu-Miller, N., & Wright, B. N. (2013). Mineral malnutrition following bariatric surgery. Advances in Nutrition, 4(5), 506-517.
  • Global Burden of Disease Collaborative Network. (2017). Global Burden of Disease Study 2015 (GBD 2015) Obesity and Overweight Prevalence 1980-2015.
  • Golzarand, M., Hollis, B. W., Mirmiran, P., & Wagner, C. L. (2018). Shab-Bidar SJEjocn. Vitamin D supplementation and body fat mass: a systematic review and meta-analysis, 1.
  • Gonzalez, J. T., Rumbold, P. L. S., & Stevenson, E. J. (2012). Effect of calcium intake on fat oxidation in adults: a meta‐analysis of randomized, controlled trials. Obesity Reviews, 13(10), 848-857.
  • Kalani, A., Bami, H., Tiboni, M., Jaeschke, R., Adachi, J. D., & Lau, A. N. (2017). The effect of bariatric surgery on serum 25‐OH vitamin D levels: a systematic review and meta‐analysis. Obesity Science & Practice, 3(3), 319-332.
  • Kampmann, U., Mosekilde, L., Juhl, C., Moller, N., Christensen, B., Rejnmark, L., & Orskov, L. (2014). Effects of 12 weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency–a double-blind, randomized, placebo-controlled trial. Metabolism, 63(9), 1115-1124.
  • Karampela, I., Sakelliou, A., Vallianou, N., Christodoulatos, G. S., Magkos, F., & Dalamaga, M. (2021). Vitamin D and obesity: current evidence and controversies. Current Obesity Reports, 10(2), 162-180.
  • Kong, J., & Li, Y. C. (2006). Molecular mechanism of 1, 25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. American Journal of Physiology-Endocrinology and Metabolism, 290(5), E916-E924.
  • LeBlanc, E. S., Rizzo, J. H., Pedula, K. L., Ensrud, K. E., Cauley, J., Hochberg, M., & Hillier, for the Study of Osteoporotic Fractures, T. A. (2012). Associations between 25-hydroxyvitamin D and weight gain in elderly women. Journal of Women's Health, 21(10), 1066-1073.
  • Lee, H., Bae, S., & Yoon, Y. (2012). Anti-adipogenic effects of 1, 25-dihydroxyvitamin D3 are mediated by the maintenance of the wingless-type MMTV integration site/β-catenin pathway. International Journal of Molecular Medicine, 30(5), 1219-1224.
  • Lips, P. (2006). Vitamin D physiology. Progress in Biophysics and Molecular Biology, 92(1), 4-8.
  • Liu, C., Wu, D., Zhang, J. F., Xu, D., Xu, W. F., Chen, Y., & Li, L. (2016). Changes in bone metabolism in morbidly obese patients after bariatric surgery: a meta-analysis. Obesity Surgery, 26(1), 91-97.
  • Mai, X. M., Chen, Y., Camargo Jr, C. A., & Langhammer, A. (2012). Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. American Journal of Epidemiology, 175(10), 1029-1036.
  • Martini, L. A., & Wood, R. J. (2006). Vitamin D status and the metabolic syndrome. Nutrition Reviews, 64(11), 479-486.
  • Mason, C., Xiao, L., Imayama, I., Duggan, C., Wang, C. Y., Korde, L., & McTiernan, A. (2014). Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. The American Journal of Clinical Nutrition, 99(5), 1015-1025.
  • Mayoral, L. P. C., Andrade, G. M., Mayoral, E. P. C., Huerta, T. H., Canseco, S. P., Canales, F. J. R., & Perez-Campos, E. (2020). Obesity subtypes, related biomarkers & heterogeneity. The Indian Journal of Medical Research, 151(1), 11.
  • Mikolasevic, I., Milic, S., Wensveen, T. T., Grgic, I., Jakopcic, I., Stimac, D., & Orlic, L. (2016). Nonalcoholic fatty liver disease-A multisystem disease?. World Journal of Gastroenterology, 22(43), 9488.
  • Milic, S., Mikolasevic, I., Krznaric-Zrnic, I., Stanic, M., Poropat, G., Stimac, D., & Orlic, L. (2015). Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options. Drug Design, Development and Therapy, 9, 4835.
  • Mutt, S. J., & Vitamin, D. (2014). D and adipose tissue-more than storage. Frontiers in Physiology, (24), 228.
  • Pannu, P. K., Zhao, Y., & Soares, M. J. (2016). Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutrition Research, 36(3), 201-213.
  • Parikh, S. J., Edelman, M., Uwaifo, G. I., Freedman, R. J., Semega-Janneh, M., Reynolds, J., & Yanovski, J. A. (2004). The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 89(3), 1196-1199.
  • Pereira‐Santos, M., Costa, P. D. F., Assis, A. D., Santos, C. D. S., & Santos, D. D. (2015). Obesity and vitamin D deficiency: a systematic review and meta‐analysis. Obesity Reviews, 16(4), 341-349.
  • Rafiq, S., & Jeppesen, P. B. (2018). Body mass index, vitamin D, and type 2 diabetes: a systematic review and meta-analysis. Nutrients, 10(9), 1182.
  • Romero-Corral, A., Somers, V. K., Sierra-Johnson, J., Thomas, R. J., Collazo-Clavell, M. L., Korinek, J. E. C., & Lopez-Jimenez, F. (2008). Accuracy of body mass index in diagnosing obesity in the adult general population. International Journal of Obesity, 32(6), 959-966.
  • Ross, A. C., Manson, J. E., Abrams, S. A., Aloia, J. F., Brannon, P. M., Clinton, S. K., ... & Shapses, S. A. (2011). The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of Clinical Endocrinology & Metabolism, 96(1), 53-58.
  • Soares, M. J., Murhadi, L. L., Kurpad, A. V., Chan She Ping‐Delfos, W. L., & Piers, L. S. (2012). Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obesity Reviews, 13(7), 592-605.
  • Targher, G., Bertolini, L., Scala, L., Cigolini, M., Zenari, L., Falezza, G., & Arcaro, G. (2007). Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutrition, Metabolism and Cardiovascular Diseases, 17(7), 517-524.
  • Tian, Z., Fan, X. T., Li, S. Z., Zhai, T., & Dong, J. (2020). Changes in bone metabolism after sleeve gastrectomy versus gastric bypass: a meta-analysis. Obesity Surgery, 30(1), 77-86.
  • Vranić, L., Mikolašević, I., & Milić, S. (2019). Vitamin D Deficiency: Consequence or Cause of Obesity?. Medicina (Kaunas, Lithuania), 55(9), 541.
  • Walsh, J. S., Bowles, S., & Evans, A. L. (2017). Vitamin D in obesity. Current Opinion in Endocrinology & Diabetes and Obesity, 24(6), 389-394.
  • Walsh, J. S., Evans, A. L., Bowles, S., Naylor, K. E., Jones, K. S., Schoenmakers, I., ... & Eastell, R. (2016). Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. The American journal of clinical nutrition, 103(6), 1465-1471.
  • Wamberg, L., Kampmann, U., Stødkilde-Jørgensen, H., Rejnmark, L., Pedersen, S. B., & Richelsen, B. (2013). Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels—results from a randomized trial. European journal of internal medicine, 24(7), 644-649.
  • Wamberg, L., Pedersen, S. B., Rejnmark, L., & Richelsen, B. (2015). Causes of vitamin D deficiency and effect of vitamin D supplementation on metabolic complications in obesity: a review. Current Obesity Reports, 4(4), 429-440.
  • Wood, R. J. (2008). Vitamin D and adipogenesis: New molecular insights. Nutrition Reviews, 66, 40–46.
  • Zemel, M. B., Shi, H., Greer, B., Dirienzo, D., Zemel, P. C. (2000). Regulation of adiposity by dietary calcium. FASEB Journal,14,1132–8.
  • Zittermann, A., Frisch, S., Berthold, H.K., Götting, C., Kuhn, J., Kleesiek, K., Stehle, P., Koertke, H., Koerfer, R. (2009). Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. American Journal of Clinical Nutrition, 89, 1321–1327.
Year 2023, , 50 - 56, 27.12.2022
https://doi.org/10.53493/avrasyasbd.1152750

Abstract

References

  • Arterburn, D. E., & Courcoulas, A. P. (2014). Bariatric surgery for obesity and metabolic conditions in adults. Bmj, 349.
  • Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2014). Vitamin D status and ill health: a systematic review. The Lancet Diabetes & Endocrinology, 2(1), 76-89.
  • Bacopoulou, F., Kolias, E., Efthymiou, V., Antonopoulos, C. N., & Charmandari, E. (2017). Vitamin D predictors in polycystic ovary syndrome: a meta‐analysis. European Journal of Clinical Investigation, 47(10), 746-755.
  • Blumberg, J. M., Tzameli, I., Astapova, I., Lam, F. S., Flier, J. S., & Hollenberg, A. N. (2006). Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. Journal of Biological Chemistry, 281(16), 11205-11213.
  • Bolland, M. J., Grey, A. B., Ames, R. W., Mason, B. H., Horne, A. M., Gamble, G. D., & Reid, I. R. (2007). The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. The American Journal of Clinical Nutrition, 86(4), 959-964.
  • Bray, G. A. (2003). Evaluation of obesity: who are the obese?. Postgraduate Medicine, 114(6), 19-38.
  • Carrelli, A., Bucovsky, M., Horst, R., Cremers, S., Zhang, C., Bessler, M., & Stein, E. M. (2017). Vitamin D storage in adipose tissue of obese and normal weight women. Journal of Bone and Mineral Research, 32(2), 237-242.
  • Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism: Clinical and Experimental, 92, 6–10. https://doi.org/10.1016/j.metabol.2018.09.005
  • Ding, C., Gao, D., Wilding, J., Trayhurn, P., & Bing, C. (2012). Vitamin D signalling in adipose tissue. British Journal of Nutrition, 108(11), 1915-1923.
  • Drincic, A., Fuller, E., Heaney, R. P., & Armas, L. A. (2013). 25-Hydroxyvitamin D response to graded vitamin D3 supplementation among obese adults. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4845-4851.
  • DSÖ, 2010. https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi Erişim: 25.05.2022
  • Earthman, C. P., Beckman, L. M., Masodkar, K., & Sibley, S. D. (2012). The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. International Journal of Obesity, 36(3), 387-396.
  • Evans, A. L., Paggiosi, M. A., Eastell, R., & Walsh, J. S. (2015). Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. Journal of Bone and Mineral Research, 30(5), 920-928.
  • Gallagher, J. C., Yalamanchili, V., & Smith, L. M. (2013). The effect of vitamin D supplementation on serum 25OHD in thin and obese women. The Journal of Steroid Biochemistry and Molecular Biology, 136, 195-200.
  • Gangloff, A., Bergeron, J., Lemieux, I., & Després, J. P. (2016). Changes in circulating vitamin D levels with loss of adipose tissue. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 464-470.
  • Gletsu-Miller, N., & Wright, B. N. (2013). Mineral malnutrition following bariatric surgery. Advances in Nutrition, 4(5), 506-517.
  • Global Burden of Disease Collaborative Network. (2017). Global Burden of Disease Study 2015 (GBD 2015) Obesity and Overweight Prevalence 1980-2015.
  • Golzarand, M., Hollis, B. W., Mirmiran, P., & Wagner, C. L. (2018). Shab-Bidar SJEjocn. Vitamin D supplementation and body fat mass: a systematic review and meta-analysis, 1.
  • Gonzalez, J. T., Rumbold, P. L. S., & Stevenson, E. J. (2012). Effect of calcium intake on fat oxidation in adults: a meta‐analysis of randomized, controlled trials. Obesity Reviews, 13(10), 848-857.
  • Kalani, A., Bami, H., Tiboni, M., Jaeschke, R., Adachi, J. D., & Lau, A. N. (2017). The effect of bariatric surgery on serum 25‐OH vitamin D levels: a systematic review and meta‐analysis. Obesity Science & Practice, 3(3), 319-332.
  • Kampmann, U., Mosekilde, L., Juhl, C., Moller, N., Christensen, B., Rejnmark, L., & Orskov, L. (2014). Effects of 12 weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency–a double-blind, randomized, placebo-controlled trial. Metabolism, 63(9), 1115-1124.
  • Karampela, I., Sakelliou, A., Vallianou, N., Christodoulatos, G. S., Magkos, F., & Dalamaga, M. (2021). Vitamin D and obesity: current evidence and controversies. Current Obesity Reports, 10(2), 162-180.
  • Kong, J., & Li, Y. C. (2006). Molecular mechanism of 1, 25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. American Journal of Physiology-Endocrinology and Metabolism, 290(5), E916-E924.
  • LeBlanc, E. S., Rizzo, J. H., Pedula, K. L., Ensrud, K. E., Cauley, J., Hochberg, M., & Hillier, for the Study of Osteoporotic Fractures, T. A. (2012). Associations between 25-hydroxyvitamin D and weight gain in elderly women. Journal of Women's Health, 21(10), 1066-1073.
  • Lee, H., Bae, S., & Yoon, Y. (2012). Anti-adipogenic effects of 1, 25-dihydroxyvitamin D3 are mediated by the maintenance of the wingless-type MMTV integration site/β-catenin pathway. International Journal of Molecular Medicine, 30(5), 1219-1224.
  • Lips, P. (2006). Vitamin D physiology. Progress in Biophysics and Molecular Biology, 92(1), 4-8.
  • Liu, C., Wu, D., Zhang, J. F., Xu, D., Xu, W. F., Chen, Y., & Li, L. (2016). Changes in bone metabolism in morbidly obese patients after bariatric surgery: a meta-analysis. Obesity Surgery, 26(1), 91-97.
  • Mai, X. M., Chen, Y., Camargo Jr, C. A., & Langhammer, A. (2012). Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. American Journal of Epidemiology, 175(10), 1029-1036.
  • Martini, L. A., & Wood, R. J. (2006). Vitamin D status and the metabolic syndrome. Nutrition Reviews, 64(11), 479-486.
  • Mason, C., Xiao, L., Imayama, I., Duggan, C., Wang, C. Y., Korde, L., & McTiernan, A. (2014). Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. The American Journal of Clinical Nutrition, 99(5), 1015-1025.
  • Mayoral, L. P. C., Andrade, G. M., Mayoral, E. P. C., Huerta, T. H., Canseco, S. P., Canales, F. J. R., & Perez-Campos, E. (2020). Obesity subtypes, related biomarkers & heterogeneity. The Indian Journal of Medical Research, 151(1), 11.
  • Mikolasevic, I., Milic, S., Wensveen, T. T., Grgic, I., Jakopcic, I., Stimac, D., & Orlic, L. (2016). Nonalcoholic fatty liver disease-A multisystem disease?. World Journal of Gastroenterology, 22(43), 9488.
  • Milic, S., Mikolasevic, I., Krznaric-Zrnic, I., Stanic, M., Poropat, G., Stimac, D., & Orlic, L. (2015). Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options. Drug Design, Development and Therapy, 9, 4835.
  • Mutt, S. J., & Vitamin, D. (2014). D and adipose tissue-more than storage. Frontiers in Physiology, (24), 228.
  • Pannu, P. K., Zhao, Y., & Soares, M. J. (2016). Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutrition Research, 36(3), 201-213.
  • Parikh, S. J., Edelman, M., Uwaifo, G. I., Freedman, R. J., Semega-Janneh, M., Reynolds, J., & Yanovski, J. A. (2004). The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 89(3), 1196-1199.
  • Pereira‐Santos, M., Costa, P. D. F., Assis, A. D., Santos, C. D. S., & Santos, D. D. (2015). Obesity and vitamin D deficiency: a systematic review and meta‐analysis. Obesity Reviews, 16(4), 341-349.
  • Rafiq, S., & Jeppesen, P. B. (2018). Body mass index, vitamin D, and type 2 diabetes: a systematic review and meta-analysis. Nutrients, 10(9), 1182.
  • Romero-Corral, A., Somers, V. K., Sierra-Johnson, J., Thomas, R. J., Collazo-Clavell, M. L., Korinek, J. E. C., & Lopez-Jimenez, F. (2008). Accuracy of body mass index in diagnosing obesity in the adult general population. International Journal of Obesity, 32(6), 959-966.
  • Ross, A. C., Manson, J. E., Abrams, S. A., Aloia, J. F., Brannon, P. M., Clinton, S. K., ... & Shapses, S. A. (2011). The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of Clinical Endocrinology & Metabolism, 96(1), 53-58.
  • Soares, M. J., Murhadi, L. L., Kurpad, A. V., Chan She Ping‐Delfos, W. L., & Piers, L. S. (2012). Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obesity Reviews, 13(7), 592-605.
  • Targher, G., Bertolini, L., Scala, L., Cigolini, M., Zenari, L., Falezza, G., & Arcaro, G. (2007). Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutrition, Metabolism and Cardiovascular Diseases, 17(7), 517-524.
  • Tian, Z., Fan, X. T., Li, S. Z., Zhai, T., & Dong, J. (2020). Changes in bone metabolism after sleeve gastrectomy versus gastric bypass: a meta-analysis. Obesity Surgery, 30(1), 77-86.
  • Vranić, L., Mikolašević, I., & Milić, S. (2019). Vitamin D Deficiency: Consequence or Cause of Obesity?. Medicina (Kaunas, Lithuania), 55(9), 541.
  • Walsh, J. S., Bowles, S., & Evans, A. L. (2017). Vitamin D in obesity. Current Opinion in Endocrinology & Diabetes and Obesity, 24(6), 389-394.
  • Walsh, J. S., Evans, A. L., Bowles, S., Naylor, K. E., Jones, K. S., Schoenmakers, I., ... & Eastell, R. (2016). Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. The American journal of clinical nutrition, 103(6), 1465-1471.
  • Wamberg, L., Kampmann, U., Stødkilde-Jørgensen, H., Rejnmark, L., Pedersen, S. B., & Richelsen, B. (2013). Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels—results from a randomized trial. European journal of internal medicine, 24(7), 644-649.
  • Wamberg, L., Pedersen, S. B., Rejnmark, L., & Richelsen, B. (2015). Causes of vitamin D deficiency and effect of vitamin D supplementation on metabolic complications in obesity: a review. Current Obesity Reports, 4(4), 429-440.
  • Wood, R. J. (2008). Vitamin D and adipogenesis: New molecular insights. Nutrition Reviews, 66, 40–46.
  • Zemel, M. B., Shi, H., Greer, B., Dirienzo, D., Zemel, P. C. (2000). Regulation of adiposity by dietary calcium. FASEB Journal,14,1132–8.
  • Zittermann, A., Frisch, S., Berthold, H.K., Götting, C., Kuhn, J., Kleesiek, K., Stehle, P., Koertke, H., Koerfer, R. (2009). Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. American Journal of Clinical Nutrition, 89, 1321–1327.
There are 51 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Esra Irmak 0000-0001-5602-9468

Rukiye Bozbulut 0000-0003-4317-9226

Publication Date December 27, 2022
Submission Date August 4, 2022
Published in Issue Year 2023

Cite

APA Irmak, E., & Bozbulut, R. (2022). D Vitamini Eksikliği ve Obezite İlişkisi. Avrasya Sağlık Bilimleri Dergisi, 6(1), 50-56. https://doi.org/10.53493/avrasyasbd.1152750
AMA Irmak E, Bozbulut R. D Vitamini Eksikliği ve Obezite İlişkisi. AvrasyaSBD. December 2022;6(1):50-56. doi:10.53493/avrasyasbd.1152750
Chicago Irmak, Esra, and Rukiye Bozbulut. “D Vitamini Eksikliği Ve Obezite İlişkisi”. Avrasya Sağlık Bilimleri Dergisi 6, no. 1 (December 2022): 50-56. https://doi.org/10.53493/avrasyasbd.1152750.
EndNote Irmak E, Bozbulut R (December 1, 2022) D Vitamini Eksikliği ve Obezite İlişkisi. Avrasya Sağlık Bilimleri Dergisi 6 1 50–56.
IEEE E. Irmak and R. Bozbulut, “D Vitamini Eksikliği ve Obezite İlişkisi”, AvrasyaSBD, vol. 6, no. 1, pp. 50–56, 2022, doi: 10.53493/avrasyasbd.1152750.
ISNAD Irmak, Esra - Bozbulut, Rukiye. “D Vitamini Eksikliği Ve Obezite İlişkisi”. Avrasya Sağlık Bilimleri Dergisi 6/1 (December 2022), 50-56. https://doi.org/10.53493/avrasyasbd.1152750.
JAMA Irmak E, Bozbulut R. D Vitamini Eksikliği ve Obezite İlişkisi. AvrasyaSBD. 2022;6:50–56.
MLA Irmak, Esra and Rukiye Bozbulut. “D Vitamini Eksikliği Ve Obezite İlişkisi”. Avrasya Sağlık Bilimleri Dergisi, vol. 6, no. 1, 2022, pp. 50-56, doi:10.53493/avrasyasbd.1152750.
Vancouver Irmak E, Bozbulut R. D Vitamini Eksikliği ve Obezite İlişkisi. AvrasyaSBD. 2022;6(1):50-6.