Ozone Application and Usage in Veterinary Medicine

Yıl 2019, Cilt: 2 Sayı: 4 - Ek sayı, 182 - 190, 30.12.2019

Derya Ünal , Tevhide Sel

Öz

In general, it has a protective effect against the harmful effects of UV rays in the living organism. After the discoveryof ozone in different patients (hepatic steatosis, chronic ulcer, orthopedic diseases, cancer, immunodeficiency,infected wounds, fistula, burn, mastitis, etc.) was used as a therapeutic agent O3 suppresses inflammatory cell factors,activates cyclooxygenase and reduces stress reactions to histiocytic oxidations and increases histiocytic ability toresist oxidation and free radicals. It increases the production of antioxidant enzymes while restoring cell homestasis.It shows free radicals due to chronic inflammation, pain relief and antiinflammatory effect. In the immune system,it acts as an ozone modulator. Different application methods such as medical ozone, intraperitoneal, intramuscular,intraarticular, subcutaneous can be applied and can cause local irrigation. The purpose of this review is to evaluatethe general properties of ozone, the application of medical ozone and its use in veterinary medicine for treatment.

Anahtar Kelimeler

Medical Ozone, Medical Ozone Application Methods, Ozone, Ozone Treatment

Ozon Uygulaması ve Veteriner Hekimlikte Kullanımı

Öz

Ozon (O3), keskin kokuya sahip olan ve ilk kez 1848 yılında keşfedilmiş renksiz bir gazdır. Genel olarak, canlı organizmadaUV ışınların zararlı etkilerine karşı koruyucu etki yaratmaktadır. Ozon keşfedildikten sonra farklı hastalarda (hepatiksteatoz, kronik ülser, ortopedik hastalıklar, kanser, immün yetmezlik, enfekte yaralar, fistül, yanık, mastitis vb.)terapotik ajan olarak kullanılmıştır. O3, enflamatuar hücre faktörlerini baskılamakta, siklooksijenazı aktive etmekteve histiyositik oksidasyonlara karşı stres reaksiyonlarını azaltmakta, oksidasyon ve serbest radikallere karşı dirençgösteren histiyositik yeteneğini artırmaktadır. Antioksidan enzimlerin üretimini artırırken hücre homestazisini iserestore etmektedir. Kronik enflamasyondan kaynaklı serbest radikalleri temizleyici, ağrı kesici ve antiinflamatuarolarak etki göstermektedir. İmmün sistemde ise ozon modülatör olarak görev yapmaktadır. Farklı uygulama yöntemleriolan tıbbi ozon, intraperitoneal, intramüsküler, intraartiküler, subkutan şeklinde uygulanabilmekte ve lokal irrigasyonaneden olabilmektedir. Bu derlemede amaç ozonun genel özelliklerini, tıbbi ozonun uygulama şekillerini ve sağaltımaçısından veteriner hekimliğinde kullanımını değerlendirmektir.

Anahtar Kelimeler

Ozon Sağaltımı, Ozon, Tıbbi Ozon, Tıbbi Ozon Uygulama Yöntemleri

Kaynakça

• Agrillo A, Ungari C, Filiaci F, Priore P, Iannetti G. (2007).Ozone Therapy in the treatmentof avascular bisphosphonaterelatedjaw osteonecrosis. J Craniofacial Surg, 18(5):1071-1075.
• Anık A. (2007). İklimlendirme Sistemlerinde OzonKullanımının İncelenmesi. Gazi Üniversitesi, Fen BilimleriEnstitüsü, Yüksek lisans tezi, 102s, Ankara
• Bocci V. (2006a). Scientific and medical aspects of ozonetherapy. State of the art. Archives of Medical Research, 37:425-435.
• Bocci V (2006b). Is It True That Ozone Is Always Toxic?The End of A Dogma. Toxicology and Applied Pharmacology,216(3): 493-504.
• Bocci V (2007). Can Ozonetherapy Be Performed. If TheBiochemistry Of The Process Cannot Be Controlled. ArchivesOf Medical Research, 38:584-585.
• Bocci VA, Zanardi I, and Travagli V. 2011. Ozone ActingOn Human Blood Yields A Hormetic Dose-ResponseRelationship. J Transl Med, 9: 66-59.
• Çağlaroğlu Ç. 2011. Farklı Seviyelerde Ozon KullanımınınErzurum İli İçme Suyunun Bazı Fiziksel, Kimyasal veMikrobiyolojik Özellikleri Üzerine Etkisi. Atatürk Üniversitesi,Fen Bilimleri Enstitüsü, Yüksek lisans tezi, 62s,
• Erzurum.Djuricic D, Lipar M, Samardzija M. (2014). Ozone TreatmentOf Metritis And Endometritis In Holstein Cows. Vet Arhiv,84(2):103-110.Dolphin S, Walker M. (1979). Healing Accelerated Byİonozone Therapy. Physiotherapy, 65(3):81-82.
• Elvis AM, Ekta JS. (2011). Ozone Therapy: A Clinical Review.J Nat Sci Biol Med, 2(1):66–70.
• Güzel Ö, Yildar E, Erdikmen DO (2011). Medical Ozone andIts Use In Veterinary Surgery. İstanbul Üniv Vet Fak Derg,37(2):177-184.
• Jakab GJ, Spannhake EW, Canning BJ, Klee-Berger SR,Gilmour MI. (1995). The Effects of Ozone On Immune Function.Environ Health Persp, 103(2):77-89.
• Kim JG, Yousef AE and Dave S (1999). Application of forEnhancing. The Microbiological Safety and Quality of Foods:A Review. J. Of Food Protect, 62(9): 1071-1087.
• Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO,Park YM (2009). Therapeutic Effects of Topical Applicationof Ozone On Acute Cutaneous Wound Healing. Journal ofKorean Medical Science, 24:368-374.
• Kucuksezer UC, Zekiroglu E, Kasapoglu P, Adin-Cinar S,Aktas-Cetin E, Deniz G. (2014). A Stim- Ulatory Role of OzoneExposure On Human Natural Killer Cells. Immunol Invest,43(1): 1-12.
• Kutlubay Z, Engin B, Serdaroğlu S, Tüzün Y. (2010).Dermatolojide Ozon Tedavisi. Dermatoz, 1(4):209-216.
• Li LJ, Yang YG, Zhang LL, Nie SF, Li Z, Li F, Hua HY, HuYJ, Zhang HS, Guo YB. (2007). Protective Effects of MedicalOzone Combined with Traditional Chinese Medicine AgainstChemically-Induced Hepatic Injury in Dogs. World JournalGastroenterolgy, 45:5989-5994
• Lu W, Li YH, He XF. (2010). Treatment of Large LumbarDisc Hemiation with Per-Cutaneous Ozone Injection Via ThePosterior-Lateral Route and Iner Magrin of the Facet Joint.World Journal of Radiology, 2:109-112.
• Mahapatra AK, Muthukumarappan K, Julson Jl. (2005).Applications of Ozone, Bacteriocins and Irradiation in FoodProcessing: A Review. Crit Rev Food Sci Nutr, 45(6):447-61.
• Mendiratta S, Qu ZC, May JM. (1998). Erythrocyte AscorbateRecycling: Antioxidant Effects in Blood. Free Radic Biol Med,24(5):789-797.
• Ogata A, Nagahata H. (2000). Intramammary Aplication ofOzone Therapy to Acute Clinical Mastitis in Dairy Cows. J VetMed Sci, 62(7):681- 686.
• Oleg V, Maslennikov A, Claudia N, Kontorshchikova C, IrinaA. (2008). Ozone Therapy In Practice. Health Manual. NizhnyNovgorod.
• Parkinson T. (2001): Urovagina. 399. In: DE Noakes,TJ Parkinson, GCW England (Ed), Arthur’s VeterinaryReproduction And Obstetrics. Saunders, Philadelphi.
• Polat B, Cengiz M, Çolak A, Cannazik O. (2015). ComparisonOf Intrauterine Ozone And Rifaximine Treatment In CowsWith Subclinical Endometritis. Kafkas Univ Vet Fak Derg,21(5):773-776.
• Rakovsky S and Zaikov G. (2009). Applıcatıon of Ozone InMedıcıne. Chemistry and Chemical Technology, 3:3.
• Romero R, Espinazo J, Mazor M. (2004). Can En-DometrialInfection/Inflammation Explain Implantation Failure,Spontaneous Abortion and Preterm Birth After In VitroFertilization? Fertil Steril, 82(4):779-804.
• Sagai M, Bocci V. (2011). Mechanisms of Action Involvedin Ozone Therapy: Is Healing Induced Via A Mild OxidativeStress? Medical Gas Research, 1:29.
• Schaur RJ. (2003). Basic Aspects of the BiochemicalReactivity of 4-Hydroxynonenal. 24: 149-159.Sharma M, Hudson JB. (2008). Ozone Gas is an Effectiveand Practical Antibacterial Agent. Am J Infect Control,36(8):559-563.
• Sheldon MI, Williams EJ, Miller AN, Nash DM, Herath S.(2008). Uterine Diseases In Cattle After Par- Turition. Vet J,176(1):115-121.
• Snyder SH. (2001). Baranano DE Heme Oxygenase: AFont Of Multiple Messengers Neuropsychopharmacology,25(3):294-298.
• Ünal, D., (2017). Ozon uygulaması ve Oksijen TutucuKullanımının Modifiye Atmosferde Ambalajlanan Tavuk EtininKalitesi Üzerine Etkileri. Ankara Üniversitesi, Fen BilimleriEnstitüsü, Yüksek Lisans Tezi, 87s, Ankara.
• Viebahn R. (1994).The Use Of Ozone In Medicine. 2nd Ed..Heidelberg: Karl F. Haug Publishers, 1-178.
• Zobel R, Tkalčić S, Stoković I, Pipal I, Buić V. (2012).Efficacy Of Ozone As A Novel Treatment Option For UrovaginaIn Dairy Cows Reprod Domest Anim, 47(2):293-298.
• Zobel R, Martinec R, Ivanovic D, Rosic N, Stancic Z, ZerjavicI. (2014). Intrauterine Ozone Administration For ImprovingFertility Rate In Simmental Cattle. Vet Arhiv, 84(1):120-123.