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Yeni Koranavirüs Hastalığının Etiyolojisi

Year 2020, Volume: 3 Issue: COVID-19, 95 - 101, 13.07.2020

Nigün Ünal

Abstract

Yeni Koronovirüs (COVID-19) enfeksiyonu ilk olarak, Aralık 2019’da Çin’in Hubei eyaletinde Wuhan şehrinde ortayaçıkmıştır. Pnömonili hastalardan alınan örneklerde yapılan, virüs izolasyonu PCR ve genom sekans çalışmalarıile etkenin %96 oranında yarasa coronovirus (BatCoV) RaTG13 ve %80 oranında da SARS-CoV’a benzediği ortayakonmuştur. İnsanları enfekte eden ve insandan insana bulaşabilen bu yeni zoonoz betacoronovirüse SARS CoV’e yakınbenzerliğinden dolayı SARS-CoV-2 (Severe Acute Respiratory Syndrome–Coronavirus-2/ SARS-CoV-2) adı verilmiştir.

Keywords

COVID-19 Koronavirüs SARS-CoV-2

References

  • Anderson RM, Fraser C, Ghani AC, Donnelly CA, Riley S, Ferguson NM, Leung GM, Lam TH, Hedley AJ, (2004). Epidemiology, trans-mission dynamics and control of SARS: the 2002- 2003 epidemic. Philosophical Transactions of the Royal Society B 359, 1091–105.
  • European Centre for Disease Prevention and Control (ECDC) (2020). Rapid Risk Assessment - Severe respiratory disease associated with a novel coronavirus . Erişim Adresi: https://www.ecdc.europa.eu/sites/default/files/ media/en/publications/Publications/novel-coronavirusrapid-risk-assessment-update.pdf Erişim Tarihi: 22.04.2014.
  • Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z, (2020). Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science ,368, 779–782.
  • Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan D. (2020). Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 12, 372. DOI: 10.3390/v12040372.
  • Lau SK, Woo PC, Yip CC, Fan RY, Huang Y, Wang M, Guo R, Lam CS, Tsang AK, Lai KK, Chan KH, Che XY, Zheng BJ, Yuen KY, (2012). Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. Journal of Virology. 86 (10): 5481–96. DOI:10.1128/JVI.06927-11.
  • Letko M, Marzi A, Munster V, (2020). Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature Microbiology, 5; 562- 569.
  • Li H, Liua SM, Yub XH, Tang SL, Tang CK, (2020). Coronavirus disease 2019 (COVID-19): current status and future perspectives. International Journal of Antimicrobial Agents, 55, 105951.
  • Li W, Shi Z, Yu M, Ren W, Smith C, Epstein J, Wang H, Crameri G, Hu Z, Zhang H, Zhang J, McEachern J, Field H, Daszak P, Eaton B, Zhang S, Wang L. (2005) Bats are natural reservoirs of SARS-like coronaviruses, Science, 310 (5748), 676-679.
  • Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, ve ark. (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet (Lond. Engl), 95,565–574. DOI: 10.1016/S0140-6736(20)30251-8.
  • Masters PS, Perlman S, (2013). Coronoviridae. In: Field Virology (Ed), 6thed., 825, Knipe DM, Howley PM. by Lippincott Williams & Wilkins Philadelphia, PA 19103 USA.
  • Parks JM, Smith JC, (2020). How to discover antiviral drugs quickly. The New England Journal of Medicine, DOI: 10.1056/ NEJMcibr2007042.
  • Peeri NC, Shrestha N, Rahman S, Zaki R, Tan Z, Bibi S, Baghbanzadeh M, Aghamohammadi N, Zhang W, Haque U, (2020). International Journal of Epidemiology, 1–10. DOI: 10.1093/ije/dyaa033.
  • Pillay TH. (2020). Gene of the Month: The 2019-nCoV/ SARS-CoV-2 Novel Coronavirus Spike Protein. Journal of Clinical Pathology, 73; 366-369. DOI: 10.1136/ jclinpath-2020-206658.
  • Satarker S, Nampoothiri M, (2020). Structural Proteins in Severe Acute Respiratory Syndrome Coronavirus-2. Medical Research Archives, DOI: 10.1016/j.arcmed.2020.05.012.
  • Tang X, Wu C, Li X, Song Y, Yao X, Wu X. Duan Y, Zhang H, Wang Y, Qian Z, ve ark. (2020). On the origin and continuing evolution of SARS-CoV-2. National Science Review, 7(6): 1012-1023. DOI: 10.1093/nsr/nwaa036.
  • Türkiye Cumhuriyeti Sağlık Bakanlığı (2020). Covid-19 Rehberi (Sars-Cov-2 Enfeksiyonu) Erişim Adresi:https:// covid19bilgi.saglik.gov.tr/depo/rehberler/covid19-rehberi/COVID-19_REHBERI_GENEL_BILGILER_ EPIDEMIYOLOJI_VE_TANI.pdf Erişim Tarihi: 01.06.2020
  • Tortora GJ, Funke BR. Case CL, (2013). Viruses, Viroids, and Prions In: Microbiology An Introduction. (Ed), 11thed., 369, Pearson Education, Inc., USA. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D, (2020). Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell, 180, 281–292. DOI:org/10.1016/j.cell.2020.02.058.
  • Wagner RR. (2020). Erişim Adresi: https:// academic.eb.com/levels/collegiate/article/ virus/106000?opensearch=sars%20covid-19%20 virus#32739.toc. Erişim tarihi: 09.06.2020
  • World Health Organisation (WHO) (2020). Disease Outbreak News. Erişim Adresi: https://www.who.int/csr/don/en/ Erişim Tarihi: 15.05.2020
  • Zhang T, Wu O, Zhang Z, (2020). Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current Biology 30, 1346–1351.
  • Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si1 HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZH. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798): 270–273. DOI: 10.1038/s41586-020-2012-7.
  • Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F et al., for the China Novel Coronavirus Investigating and Research Team (2020) A novel coronavirus from patients with pneumonia in China, 2019. The New England Journal of Medicine 3827,27-733. DOI: 10.1056/NEJMoa2001017

Etiology of New Coronavirus Disease

Year 2020, Volume: 3 Issue: COVID-19, 95 - 101, 13.07.2020

Nigün Ünal

Abstract

The new Coronovirus (COVID-19) infection first appeared in Wuhan, China in Hubei province in December 2019.Virus isolation, PCR and genome sequencing studies were carried out with samples from patients with pneumonia.According to these studies, isolated virus was determined to be 96% similar to bat Coronovirus (BatCoV) RaTG13 and80% to SARS-CoV. This new zoonotic betacoronavirus, which infects humans and can be transmitted from person toperson, has been named SARS-CoV-2 (Severe Acute Respiratory Syndrome – Coronavirus-2 / SARS-CoV-2) due to itsclose resemblance to SARS CoV.

Keywords

Coronavirus COVID-19 etiology SARS-CoV-2

References

  • Anderson RM, Fraser C, Ghani AC, Donnelly CA, Riley S, Ferguson NM, Leung GM, Lam TH, Hedley AJ, (2004). Epidemiology, trans-mission dynamics and control of SARS: the 2002- 2003 epidemic. Philosophical Transactions of the Royal Society B 359, 1091–105.
  • European Centre for Disease Prevention and Control (ECDC) (2020). Rapid Risk Assessment - Severe respiratory disease associated with a novel coronavirus . Erişim Adresi: https://www.ecdc.europa.eu/sites/default/files/ media/en/publications/Publications/novel-coronavirusrapid-risk-assessment-update.pdf Erişim Tarihi: 22.04.2014.
  • Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z, (2020). Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science ,368, 779–782.
  • Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan D. (2020). Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 12, 372. DOI: 10.3390/v12040372.
  • Lau SK, Woo PC, Yip CC, Fan RY, Huang Y, Wang M, Guo R, Lam CS, Tsang AK, Lai KK, Chan KH, Che XY, Zheng BJ, Yuen KY, (2012). Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. Journal of Virology. 86 (10): 5481–96. DOI:10.1128/JVI.06927-11.
  • Letko M, Marzi A, Munster V, (2020). Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature Microbiology, 5; 562- 569.
  • Li H, Liua SM, Yub XH, Tang SL, Tang CK, (2020). Coronavirus disease 2019 (COVID-19): current status and future perspectives. International Journal of Antimicrobial Agents, 55, 105951.
  • Li W, Shi Z, Yu M, Ren W, Smith C, Epstein J, Wang H, Crameri G, Hu Z, Zhang H, Zhang J, McEachern J, Field H, Daszak P, Eaton B, Zhang S, Wang L. (2005) Bats are natural reservoirs of SARS-like coronaviruses, Science, 310 (5748), 676-679.
  • Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, ve ark. (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet (Lond. Engl), 95,565–574. DOI: 10.1016/S0140-6736(20)30251-8.
  • Masters PS, Perlman S, (2013). Coronoviridae. In: Field Virology (Ed), 6thed., 825, Knipe DM, Howley PM. by Lippincott Williams & Wilkins Philadelphia, PA 19103 USA.
  • Parks JM, Smith JC, (2020). How to discover antiviral drugs quickly. The New England Journal of Medicine, DOI: 10.1056/ NEJMcibr2007042.
  • Peeri NC, Shrestha N, Rahman S, Zaki R, Tan Z, Bibi S, Baghbanzadeh M, Aghamohammadi N, Zhang W, Haque U, (2020). International Journal of Epidemiology, 1–10. DOI: 10.1093/ije/dyaa033.
  • Pillay TH. (2020). Gene of the Month: The 2019-nCoV/ SARS-CoV-2 Novel Coronavirus Spike Protein. Journal of Clinical Pathology, 73; 366-369. DOI: 10.1136/ jclinpath-2020-206658.
  • Satarker S, Nampoothiri M, (2020). Structural Proteins in Severe Acute Respiratory Syndrome Coronavirus-2. Medical Research Archives, DOI: 10.1016/j.arcmed.2020.05.012.
  • Tang X, Wu C, Li X, Song Y, Yao X, Wu X. Duan Y, Zhang H, Wang Y, Qian Z, ve ark. (2020). On the origin and continuing evolution of SARS-CoV-2. National Science Review, 7(6): 1012-1023. DOI: 10.1093/nsr/nwaa036.
  • Türkiye Cumhuriyeti Sağlık Bakanlığı (2020). Covid-19 Rehberi (Sars-Cov-2 Enfeksiyonu) Erişim Adresi:https:// covid19bilgi.saglik.gov.tr/depo/rehberler/covid19-rehberi/COVID-19_REHBERI_GENEL_BILGILER_ EPIDEMIYOLOJI_VE_TANI.pdf Erişim Tarihi: 01.06.2020
  • Tortora GJ, Funke BR. Case CL, (2013). Viruses, Viroids, and Prions In: Microbiology An Introduction. (Ed), 11thed., 369, Pearson Education, Inc., USA. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D, (2020). Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell, 180, 281–292. DOI:org/10.1016/j.cell.2020.02.058.
  • Wagner RR. (2020). Erişim Adresi: https:// academic.eb.com/levels/collegiate/article/ virus/106000?opensearch=sars%20covid-19%20 virus#32739.toc. Erişim tarihi: 09.06.2020
  • World Health Organisation (WHO) (2020). Disease Outbreak News. Erişim Adresi: https://www.who.int/csr/don/en/ Erişim Tarihi: 15.05.2020
  • Zhang T, Wu O, Zhang Z, (2020). Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current Biology 30, 1346–1351.
  • Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si1 HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZH. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798): 270–273. DOI: 10.1038/s41586-020-2012-7.
  • Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F et al., for the China Novel Coronavirus Investigating and Research Team (2020) A novel coronavirus from patients with pneumonia in China, 2019. The New England Journal of Medicine 3827,27-733. DOI: 10.1056/NEJMoa2001017
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Nigün Ünal 0000-0002-0490-976X

Publication Date July 13, 2020
Submission Date June 17, 2020
Published in Issue Year 2020 Volume: 3 Issue: COVID-19

Cite

APA Ünal, N. (2020). Yeni Koranavirüs Hastalığının Etiyolojisi. Avrasya Sağlık Bilimleri Dergisi, 3(COVID-19), 95-101.
AMA Ünal N. Yeni Koranavirüs Hastalığının Etiyolojisi. AvrasyaSBD. July 2020;3(COVID-19):95-101.
Chicago Ünal, Nigün. “Yeni Koranavirüs Hastalığının Etiyolojisi”. Avrasya Sağlık Bilimleri Dergisi 3, no. COVID-19 (July 2020): 95-101.
EndNote Ünal N (July 1, 2020) Yeni Koranavirüs Hastalığının Etiyolojisi. Avrasya Sağlık Bilimleri Dergisi 3 COVID-19 95–101.
IEEE N. Ünal, “Yeni Koranavirüs Hastalığının Etiyolojisi”, AvrasyaSBD, vol. 3, no. COVID-19, pp. 95–101, 2020.
ISNAD Ünal, Nigün. “Yeni Koranavirüs Hastalığının Etiyolojisi”. Avrasya Sağlık Bilimleri Dergisi 3/COVID-19 (July 2020), 95-101.
JAMA Ünal N. Yeni Koranavirüs Hastalığının Etiyolojisi. AvrasyaSBD. 2020;3:95–101.
MLA Ünal, Nigün. “Yeni Koranavirüs Hastalığının Etiyolojisi”. Avrasya Sağlık Bilimleri Dergisi, vol. 3, no. COVID-19, 2020, pp. 95-101.
Vancouver Ünal N. Yeni Koranavirüs Hastalığının Etiyolojisi. AvrasyaSBD. 2020;3(COVID-19):95-101.
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