Research Article
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The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency

Year 2024, Volume: 7 Issue: 2, 98 - 105, 30.05.2024
https://doi.org/10.53493/avrasyasbd.1435125

Abstract

Aim: Due to chronic diseases that occur with advancing age, the number of medications used in geriatric individuals increases dramatically. This increment necessitates the rational use of drugs within a proper program. Reasonable drug use can affect individuals' adaptation to the diseases and their quality of life. This research was undertaken to explore the impact of rational drug use on disease adaptation and life Quality in geriatric patients with heart failure.
Materials and Method: The research involved a cohort of 322 individuals aged 65 and above. Participants completed a patient information form, including the Rational Drug Use Scale, the Chronic Disease Adjustment Scale, and the Elderly Quality of Life Scale (CASP-19). Statistical comparisons utilized t-tests, Mann-Whitney U tests, and ANOVA tests, while Pearson correlation analysis was employed to assess the associations between scale scores. Significance was determined for conditions with p-values less than 0.05.
Results: The study revealed a notable correlation between the patients' levels of rational drug use and their adaptation to the disease (r=0.226; p<0.001). Conversely, no significant relationship was observed between reasonable drug use and quality of life (r=-0.039; p=0.486). Nevertheless, upon examining the sub-dimensions of the Rational Drug Use Scale (RDUS) and the Elderly Quality of Life Scale (CASP-19), a weak but statistically significant relationship emerged between these sub-dimensions (r=-0.191; p˂0.001). No significant difference was found between the polypharmacy and non-polypharmacy groups in comparing RDUS, ACIS, and CASP-19 scale scores and sub-dimension total scores (p>0.05). However, only in the group with polypharmacy was the total score of the physical adaptation sub-dimension of the ACIS significantly lower (p=0.011).
Conclusion and Suggestions: The research findings indicated that rational drug use among geriatric individuals positively influenced their ability to adapt to the disease, albeit resulting in a comparatively modest impact on the sub-dimensions of quality of life. Further studies are needed to evaluate rational drug use and to investigate its effect on symptom control, patient satisfaction, and quality of life in patients with heart failure.

References

  • Alkan S, Nural N. (2017). Can be prevented re-hospitalizations in heart failure? Turkish J Card Nur, 8(16):28-34. doi:10.5543/ khd.2017.25238
  • Appleton, SC, Abel GA, Payne RA. (2014). Cardiovascular polypharmacy is not associated with unplanned hospitalisation: evidence from a retrospective cohort study. BMC Family Practice, 15(1):1-8. https://link.springer. com/article/10.1186/1471-2296-15-58 (accessed October 14, 2023).
  • Atik D, Karatepe H. (2016). Scale development study: adaptation to chronic illness. Acta Medica Mediterranea, 32(1):135-142. doi:10.19193/0393-6384_2016_1_21
  • Burch, JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC. (2014). Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci, 69(1):1-3. doi:10.1093/gerona/glu041
  • Butrous H, Hummel SL. (2016). Heart failure in older adults. Canadian J Cardiol, 32(9):1140-1147. doi:10.1016/j. cjca.2016.05.005
  • Cakmak V, Pakyuz SC. (2020). A methodological study: development of the rational drug use scale. Journal of Anatolia Nursing and Health Sciences, 23(4): 498-507. doi: 10.17049/ataunihem.595394
  • Ewen S, Baumgarten T, Ewen VR, Mahfoud F, Mammen NG, Schulz M. Böhm M, Laufs U. (2015). Analyses of drugs stored at home by elderly patients with chronic heart failure. Clinical Research in Cardiology, 104(4):320-327. doi:10.1007/s00392-014-0783-2
  • Faul F, Erdfelder E, Lang AG, Buchner A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2):175–191. doi:10.3758/bf03193146
  • Groenewegen A, Rutten FH, Mosterd A, Hoes AW. (2020). Epidemiology of heart failure. Eur J Heart Fail, 22(8):1342- 1356. doi:10.1002/ejhf.1858
  • Gyasi RM, Phillips DR. (2019). Aging and the rising burden of noncommunicable diseases in Sub-Saharan Africa and other low- and middle-income countries: a call for holistic action. The Gerontologist, 60(5): 806-811. doi:10.1093/ geront/gnz102
  • Hoekstra H, Leegte IL, Van Veldhuisen DJ, Sanderman R, Jaarsma T. (2011). Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. Eur J Heart Fail, 13(9):1013-1018. doi:10.1093/ eurjhf/hfr072.
  • Hyde M, Wiggins RD, Higgs P, Blane DB. (2003). A measure of quality of life in early old age: the theory, development and properties of a needs satisfaction model (CASP-19). Aging & Mental Health, 7(3):186-94. doi:10.1080/1360786031000101157
  • Jüngst C, Graber S, Simons S, Wedemeyer H, Lammert F. (2019). Medication adherence among patients with chronic diseases: a survey- based study in pharmacies. QJM, 112(7):505-512. doi:10.1093/qjmed/hcz058.
  • Kitaw TA, Haile RN. (2023). Prevalence of polypharmacy among older adults in Ethiopia:a systematic review and meta-analysis. Meta-Analysis Scientific Report, 13(1):17641. doi:10.1038/s41598-023-45095-2.
  • Mastromarino V, Casenghi M, Testa M, Gabriele E, Coluccia R, Rubattu S, Volpe M. (2014). Polypharmacy in heart failure patients. Curr Heart Fail Rep, 11(2):212-219. doi:10.1007/ s11897-014-0186-8
  • Maxwell SRJ. (2016). Rational prescribing: the principles of drug selection. Clin Med (Lond), 16(5):459-464. doi: 10.7861/ clinmedicine.16-5-459
  • MSD Manual Professional Version (MSD) (2021). Overview of drug therapy in older adults. https://www.msdmanuals. com/professiona l/geriatrics (accessed September 11, 2023).
  • Olsson IN, Runnamo R, Engfeldt P. (2011). Medication quality and quality of life in the elderly, a cohort study. Health Qual Life Outcomes, 9(95):1-9. doi: 10.1186/1477-7525-9-95
  • Open Source Epidemiologic Statistics for Public Health (2013). Sample size for a proportion or descriptive study. http:// www.openepi.com/SampleSize/SSPropor.htm (accessed December 17, 2023).
  • Ragbaoui Y, Nouamou I, El Hammiri A, Habbal R. (2017). Predictive factors of medication adherence in patients with chronic heart failure: Morocco’s experience. Pan Afr Med J, 26(115):1-4. doi:10.11604/pamj.2017.26.115.11471
  • Savarese G, Hund LH. (2017). Global public health burden of hearth failure. Card Fail Rev, 3(1):7-11. doi:10.15420/ cfr.2016:25:2
  • Shrestha R, Prajapati S. (2019). Assessment of prescription pattern and prescription error in outpatient department at tertiary care district hospital, central Nepal. J Pharm Policy Pract, 16(12):1-9. doi:10.1186/s40545-019-0177-y
  • Silavanich V, Nathisuwan S, Phrommintikul A, Permsuwan U. (2018). Relationship of medication adherence and quality of life among heart failure patients. Heart&Lung, 48(2):105- 110. doi:10.1016/j.hrtlng.2018.09.009
  • Turkoglu N, Adıbelli D. (2014). Adaptation of quality of life scale in older people (CASP-19) to Turkish society. The Journal of Academic Geriatrics, 6:98-105.
  • https://toad.halileksi.net/wp-content/uploads/2022/07/ yaslilarda-yasam-kalitesi-olcegi-casp-19-toad_0.pdf (accessed November 15, 2023).
  • Unlu O, Levitan, EB, Reshetnyak E, Hayek JK, Diaz I, Archambault A, Chen L, Hanlon JT, Maurer MS, Safford MM, Lachs MS, Goyal P. (2020). Polypharmacy in older adults hospitalized for heart failure. Circ Heart Fail, 13(11):1-22. doi:10.1016/CIRCHEARTFAILURE.120.006977

Kalp Yetersizliği Olan Geriatrik Bireylerde Akılcı İlaç Kullanımının Hastalığa Uyum Ve Yaşam Kalitesine Etkisi

Year 2024, Volume: 7 Issue: 2, 98 - 105, 30.05.2024
https://doi.org/10.53493/avrasyasbd.1435125

Abstract

Amaç: İlerleyen yaşla birlikte ortaya çıkan kronik hastalıklar nedeniyle geriatrik bireylerde ilaç kullanım miktarı artar. Bu artış ilaçların bir program dâhilinde akılcı bir şekilde kullanılmasını zorunlu kılar. Akılcı ilaç kullanımı bireylerin hastalığa uyumunu ve yaşam kalitesini etkileyebilir. Bu araştırma geriatrik ve kalp yetersizliği olan hastalarda akılcı ilaç kullanımının hastalığa uyum ve yaşam kalitesine etkisini incelemek amacıyla yapılmıştır.
Yöntem: Araştırmanın örneklemini 65 yaş üstü 322 kişi oluşturmuştur. Katılımcılara hasta tanıtım bilgi formu, Akılcı İlaç Kullanım Ölçeği, Kronik Hastalıklara Uyum Ölçeği ve Yaşlılarda Yaşam Kalitesi Ölçeği (CASP-19) uygulandı. Verilerin analizinde; karşılaştırmalar için t-testi, Mann-Whitney U ve ANOVA testi kullanılırken, ölçek skorları arasında ilişkiyi incelemek için ise Pearson korelasyon analizi kullanıldı. p<0,05 olduğu durum anlamlı kabul edildi.
Bulgular: Hastaların akılcı ilaç kullanım düzeyinin hastalığa uyum üzerinde anlamlı bir ilişkisi yarattığı görüldü. (r=0,226; p<0,001) Akılcı ilaç kullanım düzeyi ile yaşam kalitesi ilişkilendirildiğinde herhangi bir ilişkinin var olmadığı görüldü (r=-0,039; p=0,486). Ancak, akılcı ilaç kullanım ölçeği ile yaşlılarda yaşam kalitesi ölçeğinin alt boyutlarından kontrol, otonomi ve zevk arasında anlamlı ilişki bulundu (sırasıyla; r=0,160; p=0,004 ; r=-0,119; p=0,032 ; r=-0,191; p˂0,0001). Polifarmasi ve polifarmasi olmayan gruplar arasında AİKÖ, KHUÖ ve CASP-19 ölçek puanlarının ve altı boyut toplam puanlarının karşılaştırılmasında anlamlı fark bulunmadı (p>0,05). Ancak, sadece polifarmasi olan grupta KHUÖ’de fiziksel uyum alt boyut toplam puan anlamlı düşük bulundu (p=0,011).
Sonuç ve Öneriler: Çalışmada, geriatrik bireylerde akılcı ilaç kullanımının hastalığa uyum süreci üzerinde daha olumlu bir etki yarattığı, yaşam kalitesi arasında ise alt boyutlarda daha zayıf bir değişime neden olduğu sonucuna ulaşılmıştır. Akılcı ilaç kullanımının değerlendirilip kalp yetersizliği olan hastalarda semptom kontrolü, hastanın memnuniyeti ve yaşam kalitesi üzerine etkisinin yeni çalışmalarda araştırılmasına gereksinim vardır.

Ethical Statement

Çalışmada Helsinki kriterlerine göre yürütülmüştür. Aydın Adnan Menderes Üniversitesinden Etik kurul izin onayı ve çalışmanın yapılacağı kurum izni alınmıştır.

Supporting Institution

YOK

Thanks

Çalışmaya gönüllü katılım sağlayan bireylere teşekkür ederiz.

References

  • Alkan S, Nural N. (2017). Can be prevented re-hospitalizations in heart failure? Turkish J Card Nur, 8(16):28-34. doi:10.5543/ khd.2017.25238
  • Appleton, SC, Abel GA, Payne RA. (2014). Cardiovascular polypharmacy is not associated with unplanned hospitalisation: evidence from a retrospective cohort study. BMC Family Practice, 15(1):1-8. https://link.springer. com/article/10.1186/1471-2296-15-58 (accessed October 14, 2023).
  • Atik D, Karatepe H. (2016). Scale development study: adaptation to chronic illness. Acta Medica Mediterranea, 32(1):135-142. doi:10.19193/0393-6384_2016_1_21
  • Burch, JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC. (2014). Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci, 69(1):1-3. doi:10.1093/gerona/glu041
  • Butrous H, Hummel SL. (2016). Heart failure in older adults. Canadian J Cardiol, 32(9):1140-1147. doi:10.1016/j. cjca.2016.05.005
  • Cakmak V, Pakyuz SC. (2020). A methodological study: development of the rational drug use scale. Journal of Anatolia Nursing and Health Sciences, 23(4): 498-507. doi: 10.17049/ataunihem.595394
  • Ewen S, Baumgarten T, Ewen VR, Mahfoud F, Mammen NG, Schulz M. Böhm M, Laufs U. (2015). Analyses of drugs stored at home by elderly patients with chronic heart failure. Clinical Research in Cardiology, 104(4):320-327. doi:10.1007/s00392-014-0783-2
  • Faul F, Erdfelder E, Lang AG, Buchner A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2):175–191. doi:10.3758/bf03193146
  • Groenewegen A, Rutten FH, Mosterd A, Hoes AW. (2020). Epidemiology of heart failure. Eur J Heart Fail, 22(8):1342- 1356. doi:10.1002/ejhf.1858
  • Gyasi RM, Phillips DR. (2019). Aging and the rising burden of noncommunicable diseases in Sub-Saharan Africa and other low- and middle-income countries: a call for holistic action. The Gerontologist, 60(5): 806-811. doi:10.1093/ geront/gnz102
  • Hoekstra H, Leegte IL, Van Veldhuisen DJ, Sanderman R, Jaarsma T. (2011). Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. Eur J Heart Fail, 13(9):1013-1018. doi:10.1093/ eurjhf/hfr072.
  • Hyde M, Wiggins RD, Higgs P, Blane DB. (2003). A measure of quality of life in early old age: the theory, development and properties of a needs satisfaction model (CASP-19). Aging & Mental Health, 7(3):186-94. doi:10.1080/1360786031000101157
  • Jüngst C, Graber S, Simons S, Wedemeyer H, Lammert F. (2019). Medication adherence among patients with chronic diseases: a survey- based study in pharmacies. QJM, 112(7):505-512. doi:10.1093/qjmed/hcz058.
  • Kitaw TA, Haile RN. (2023). Prevalence of polypharmacy among older adults in Ethiopia:a systematic review and meta-analysis. Meta-Analysis Scientific Report, 13(1):17641. doi:10.1038/s41598-023-45095-2.
  • Mastromarino V, Casenghi M, Testa M, Gabriele E, Coluccia R, Rubattu S, Volpe M. (2014). Polypharmacy in heart failure patients. Curr Heart Fail Rep, 11(2):212-219. doi:10.1007/ s11897-014-0186-8
  • Maxwell SRJ. (2016). Rational prescribing: the principles of drug selection. Clin Med (Lond), 16(5):459-464. doi: 10.7861/ clinmedicine.16-5-459
  • MSD Manual Professional Version (MSD) (2021). Overview of drug therapy in older adults. https://www.msdmanuals. com/professiona l/geriatrics (accessed September 11, 2023).
  • Olsson IN, Runnamo R, Engfeldt P. (2011). Medication quality and quality of life in the elderly, a cohort study. Health Qual Life Outcomes, 9(95):1-9. doi: 10.1186/1477-7525-9-95
  • Open Source Epidemiologic Statistics for Public Health (2013). Sample size for a proportion or descriptive study. http:// www.openepi.com/SampleSize/SSPropor.htm (accessed December 17, 2023).
  • Ragbaoui Y, Nouamou I, El Hammiri A, Habbal R. (2017). Predictive factors of medication adherence in patients with chronic heart failure: Morocco’s experience. Pan Afr Med J, 26(115):1-4. doi:10.11604/pamj.2017.26.115.11471
  • Savarese G, Hund LH. (2017). Global public health burden of hearth failure. Card Fail Rev, 3(1):7-11. doi:10.15420/ cfr.2016:25:2
  • Shrestha R, Prajapati S. (2019). Assessment of prescription pattern and prescription error in outpatient department at tertiary care district hospital, central Nepal. J Pharm Policy Pract, 16(12):1-9. doi:10.1186/s40545-019-0177-y
  • Silavanich V, Nathisuwan S, Phrommintikul A, Permsuwan U. (2018). Relationship of medication adherence and quality of life among heart failure patients. Heart&Lung, 48(2):105- 110. doi:10.1016/j.hrtlng.2018.09.009
  • Turkoglu N, Adıbelli D. (2014). Adaptation of quality of life scale in older people (CASP-19) to Turkish society. The Journal of Academic Geriatrics, 6:98-105.
  • https://toad.halileksi.net/wp-content/uploads/2022/07/ yaslilarda-yasam-kalitesi-olcegi-casp-19-toad_0.pdf (accessed November 15, 2023).
  • Unlu O, Levitan, EB, Reshetnyak E, Hayek JK, Diaz I, Archambault A, Chen L, Hanlon JT, Maurer MS, Safford MM, Lachs MS, Goyal P. (2020). Polypharmacy in older adults hospitalized for heart failure. Circ Heart Fail, 13(11):1-22. doi:10.1016/CIRCHEARTFAILURE.120.006977
There are 26 citations in total.

Details

Primary Language English
Subjects Aged Health Care
Journal Section Articles
Authors

Taner Akarsu 0000-0002-1337-3178

Çağdaş Akgüllü 0000-0003-4978-1955

Publication Date May 30, 2024
Submission Date February 11, 2024
Acceptance Date May 8, 2024
Published in Issue Year 2024 Volume: 7 Issue: 2

Cite

APA Akarsu, T., & Akgüllü, Ç. (2024). The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency. Avrasya Sağlık Bilimleri Dergisi, 7(2), 98-105. https://doi.org/10.53493/avrasyasbd.1435125
AMA Akarsu T, Akgüllü Ç. The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency. EurasianJHS. May 2024;7(2):98-105. doi:10.53493/avrasyasbd.1435125
Chicago Akarsu, Taner, and Çağdaş Akgüllü. “The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients With Cardiac Insufficiency”. Avrasya Sağlık Bilimleri Dergisi 7, no. 2 (May 2024): 98-105. https://doi.org/10.53493/avrasyasbd.1435125.
EndNote Akarsu T, Akgüllü Ç (May 1, 2024) The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency. Avrasya Sağlık Bilimleri Dergisi 7 2 98–105.
IEEE T. Akarsu and Ç. Akgüllü, “The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency”, EurasianJHS, vol. 7, no. 2, pp. 98–105, 2024, doi: 10.53493/avrasyasbd.1435125.
ISNAD Akarsu, Taner - Akgüllü, Çağdaş. “The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients With Cardiac Insufficiency”. Avrasya Sağlık Bilimleri Dergisi 7/2 (May 2024), 98-105. https://doi.org/10.53493/avrasyasbd.1435125.
JAMA Akarsu T, Akgüllü Ç. The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency. EurasianJHS. 2024;7:98–105.
MLA Akarsu, Taner and Çağdaş Akgüllü. “The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients With Cardiac Insufficiency”. Avrasya Sağlık Bilimleri Dergisi, vol. 7, no. 2, 2024, pp. 98-105, doi:10.53493/avrasyasbd.1435125.
Vancouver Akarsu T, Akgüllü Ç. The Effect of Rational Drug Usage on Disease Adaptation and Quality of Life in Geriatric Patients with Cardiac Insufficiency. EurasianJHS. 2024;7(2):98-105.