Inflammation in Patients with Opiate Use Disorder: Neutrophil/Lymphocyte, Platelet/Lymphocyte, Monocyte/Lymphocyte Ratios and Mean Platelet Volume

Abstract

Objective: The aim of this study was to retropeectivelyt analyse the inflammation markers such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLO), and monocyte-lymphocyte ratio (PLO), of the patients with opiate use disorder (OUD) by comparing them with healthy controls. Method: 201 people (101 people OUD, 100 control) were included in the study. A demographic data form containing demographic data such as age and gender of all participants was created. Afterwards, laboratory parameters evaluated by complete blood count were examined. Results: All participants were male and mean age 30.68±10.60. Hemoglobin values 14.78±1.29, hematocrit values 44.02±3.70 for patients group. Erythrocyte 5.00±0.39 and RDW-SD values 43.90±4.26; These values were higher in patients than in healthy controls. NLR, MLR and PLR values were lower in the patient group compared to the controls. Conclusion: There are changes in some inflammatory parameters in OUD patients. Complications that may occur due to these changes in inflammatory parameters; should be considered in both the treatment plan and the evaluation of the patient's symptoms.

Keywords

• Opiate use disorder
• inflammation
• neutrophil/lymphocyte ratio

Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Öz

Amaç: Bu çalışmada; Opiyat Kullanım Bozukluğu (OpKB) tanılı hastaların nötrofil/lenfosit (NLO), platelet/lenfosit (PLO), monosit/lenfosit (PLO) oranı gibi periferik inflamasyon belirteçlerini kontroller ile karşılaştırarak retrospektif incelemeyi amaçladık. Yöntem: Çalışmaya; 201 kişi (101 kişi OpKB ve 100 kontrol) alındı. Tüm katılımcıların yaş, cinsiyet gibi demografik verilerini içeren demografik veri formu oluşturuldu. Sonrasında tam kan sayımı ile değerlendirilen laboratuvar parametreleri incelendi. Bulgular: Tüm katılımcılar erkek ve yaş ortalaması 30,68±10,60 idi. Hasta grubunun hemoglobin değeri 14,78±1,29, hematokrit değeri 44,02±3,70 olarak hesap edildi. Yine hastalarda eritrosit 5,00±0,39 ve RDW-SD 43,90±4,26 ile sağlıklı kontrollerden yüksekti. NLO, MLO ve PLO değerleri hasta grubunda sağlıklı kontrollere göre düşük olarak hesap edildi. Sonuç: OpKB hastalarında bazı inflamatuvar parametrelerinde değişiklikler olduğu gösterilmiştir. İnflamatuvar parametrelerindeki bu değişikliklere bağlı oluşabilecek komplikasyonlar; hem tedavi planı hem hastanın semptomlarının değerlendirilmesinde dikkate alınmalıdır.

Anahtar Kelimeler

• Opiyat kullanım bozukluğu
• inflamasyon
• nötrofil/lenfosit oranı
• trombosit/lenfosit oranı
• monosit/lenfosit oranı.
• Opiate use disorder
• inflammation
• neutrophil/lymphocyte ratio

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