Alkol Kullanım Bozukluğunun Detoksifikasyon Tedavisi Sırasında Yoksunluk Şiddeti İle İnflamasyon Parametreleri Arasındaki İlişki ̇

Öz

Amaç: Alkol yoksunluğu, alkol alımının kesilmesinden veya azaltılmasından sonra görülebilen, potansiyel olarak yaşamı tehdit eden bir durumdur. İnflamatuar süreçler alkol yoksunluk süresinde yer alır. Bu çalışmada alkol yoksunluk şiddeti ile inflamasyon parametreleri arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntem: Bu retrospektif çalışma Ağustos-2021 ve Ağustos-2022 tarihleri arasında bir alkol ve uyuşturucu madde tedavi merkezinde elektronik sağlık kayıtları üzerinden gerçekleştirilmiştir. Alkol kullanım bozukluğu olan 141 hasta ve 134 kontrol grubu çalışmaya dahil edilmiştir. Katılımcıların sosyodemografik, klinik ve biyokimyasal verileri toplanmıştır. Bulgular: Hastaların ve kontrol grubunun yaş, cinsiyet ve eğitim durumu açısından benzer oldukları görülmüştür. Hasta grubunun, kontrol grubundan daha yüksek nötrofil seviyelerine ve daha düşük lenfosit seviyelerine sahip olduğu; nötrofil-lenfosit oranı (NLO) ve monosit-lenfosit oranı (MLO) düzeylerinin de hasta grubunda daha yüksek olduğu saptanmıştır. Hastaların alkol yoksunluk şiddetinin NLO düzeyleri, MLO düzeyleri, günlük alkol miktarı ve ağır alkol tüketim süresi ile pozitif korelasyon gösterdiği görülmüştür. Sonuç: NLO ve MLO, alkol yoksunluk şiddetini tahmin etmek için kullanılabilecek ucuz ve kolay erişilebilir belirteçlerdir

Anahtar Kelimeler

• alkol ilişkili bozukluklar
• inflammasyon
• nötrofil
• lenfosit
• alkol yoksunluk semptomları

Relationship between Withdrawal Severity and Inflammation Parameters during the Detoxification Treatment of Alcohol Use Disorder

Abstract

Objective: Alcohol withdrawal is a potentially life-threatening condition that could be seen after discontinuation or a decrease in alcohol consumption. Inflammatory processes take part in alcohol withdrawal duration. This study aimed to investigate the relationship between withdrawal severity and inflammation parameters. Method: This retrospective study was performed via electronic health records in an alcohol and drug treatment center between August-2021 and August-2022. One hundred forty-one inpatients with alcohol use disorder and 134 controls were enrolled. Sociodemographic, clinical, and biochemical data of the participants were collected. Results: The patients and the control group were similar in age, gender, and educational status. The patients’ group had higher levels of neutrophils and lower levels of lymphocytes than the control group. Neutrophil-to-lymphocyte (NLR) and monocyte-to-lymphocyte ratio (MLR) levels were higher in the patients’ group. The alcohol withdrawal severity of patients was positively correlated with NLR levels, MLR levels, the amount of daily alcohol, and years of heavy alcohol consumption. Conclusion: NLR and MLR are inexpensive and easily accessible markers that could be used to estimate alcohol withdrawal severity.

Keywords

• alcohol-related disorders
• inflammation
• neutrophils
• lymphocytes
• withdrawal symptoms

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