Prevalence of Gabapentin and Pregabalin Use in Patients with Opioid Use Disorder

Abstract

Objective: The aim of this study is to investigate the frequency of use of gabapentin and pregabalin in patients who applied to the AMATEM outpatient clinic for opioid use. Method: The study included one hundred forty-four patients with opioid use disorder who were currently using opioids or were receiving buprenorphine/naloxone treatment. Opioid and gabapentinoid use were evaluated with a semi-structured interview protocol. Results: The lifetime prevalence of gabapentin and pregabalin use was 51.4% and 50.7%, respectively. At the time of admission to the outpatient clinic, 35.4% of the patients were using gabapentin and 26.4% were using pregabalin. 46% of the patients using buprenorphine/naloxone used both pregabalin and gabapentin. There was no difference in the frequency of gabapentinoid use between the patients using opioids with foil and the patients using IV opioids. Conclusion: Patients with a history of opioid use appear to constitute a high-risk group for gabapentinoid abuse. It may be appropriate for physicians following patients using opioids to be careful while prescribing gabapentinoids for patients at risk of abuse and to recommend alternative drugs to gabapentinoids.

Keywords

• Gabapentin
• pregabalin
• opioid

Opioid Kullanım Bozukluğu Olan Hastalarda Gabapentin ve Pregabalin Kullanım Sıklığı

Öz

Amaç: Bu çalışmanın amacı AMATEM polikliniğine opioid kullanımı nedeniyle başvuran hastalarda gabapentin ve pregabalin kullanım sıklığının araştırılmasıdır. Yöntem: Çalışmaya halen opioid kullanan veya buprenorfin/ naloksan tedavisi alan 144 opioid kullanım bozukluğu olan hasta alındı.Yarı yapılandırılmış görüşme protokolü ile opioid ve gabapentinoid kullanımları değerlendirildi. Bulgular:Yaşam boyu gabapentin ve pregabalin kullanım sıklığı sırasıyla %51,4 ve %50,7 olarak bulundu. Polikliniğe başvurduğu sırada hastaların %35,4’ü gabapentin, %26,4’ü pregabalin kullanıyordu. Buprenorfin/naloksan kullanan hastaların %46’sının hem pregabalin hem de gabapentin kullandığı bulundu. Folyo ile opioid kullanan hastalar ile damardan kullanan hastalar arasında gabapentinoid kullanım sıklığı arasında herhangi bir fark bulunmadı. Sonuç: Opioid kullanım öyküsü olan hastaların gabapentinoid kötüye kullanımı için yüksek riskli bir grup oluşturduğu görülmektedir. Opioid kullanan hastaları takip eden hekimlerin kötüye kullanma riski olan hastalarda gabapentinoid reçete ederken dikkatli olmaları ve hastalara gabapentinoidlere alternatif ilaçlar önermeleri uygun olabilir.

Anahtar Kelimeler

• Gabapentin
• Pregabalin
• Opioid

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