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Ankilozan Spondilit Hastalarında Nikotin Bağımlılığı Riski ve Sigarayı Bırakma Zorluğunun Değerlendirilmesi

Year 2025, Volume: 26 Issue: 4, 451 - 458, 30.12.2025
https://doi.org/10.51982/bagimli.1651164

Abstract

Amaç: Sigara romatizmal hastalıklar için bir risk faktörüdür. Bu çalışmanın amacı ankilozan spondilit (AS) hastalarında yüksek nikotin bağımlılığı riski ile hastalık aktivitesi arasındaki ilişkiyi ve bağımlılık riski düzeyi ile sigarayı bırakma zorluğunu değerlendirmektir.
Yöntem: Bu çalışma kesitsel bir çalışmadır. Çalışmaya Kasım 2022 ve Eylül 2023 tarihleri arasında AS tanısı konmuş toplam 65 hasta dahil edilmiştir. Hasta tanımlama formu, Bath Ankilozan Spondilit Hastalık Aktivite İndeksi, Ankilozan Spondilit Yaşam Kalitesi Anketi, Fagerström Nikotin Bağımlılık İndeksi ve Sigarayı Bırakma Zorlukları Anketi kullanılmıştır.
Bulgular: 36 hastanın (%55,4) orta ile şiddetli nikotin bağımlılığı riski mevcuttu. Hastaların 50'sinin (%77) hastalık aktivitesinin orta -yüksek olduğu ve bu hastaların nikotin bağımlılık riski skorları yüksek ve yaşam kalitesi skorları düşük bulundu. Tüm hastalar arasında 42'si (%65) sigarayı bırakmaya istekli olduğunu ifade etti, ancak bu durum orta-yüksek hastalık aktivitesi olanlarda önemli ölçüde daha zorlayıcıydı.
Sonuç: Sigara AS' de hastalık aktivitesini etkilediği düşünülen değiştirilebilir faktörlerden biridir. Sigaranın bırakılması AS tedavisinde tedavi önerileri arasında yer alsa da, sigara içenlerin önemli bir kısmı (yaklaşık üçte ikisi) çok istemelerine rağmen yüksek nikotin bağımlılık riski nedeniyle sigarayı bırakamamaktadır.

Project Number

-

References

  • Chen CH, Chen HA, Lu CL, et al. Association of cigarette smoking with Chinese ankylosing spondylitis patients in Taiwan: a poor disease outcome in systemic inflammation, functional ability, and physical mobility. Clin Rheumatol 2013; 32(5): 659-663.
  • Stolt P, Bengtsson C, Nordmark B, et al. EIRA study group. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population-based case-control study, using incident cases. Ann Rheum Dis 2003; 62(9): 835-841.
  • Criswell LA, Merlino LA, Cerhan JR, et al. Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study. Am J Med 2002; 112(6): 465-471.
  • Costenbader KH, Kim DJ, Peerzada J, et al. Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 2004; 50(3): 849-857.
  • Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum 2012; 64: 1388-1398.
  • Kaut IK, Abourazzak FE, Jamila E, el al. Axial spondyloarthritis and cigarette smoking. The Open Rheumatology J 2017; 11: 53-61.
  • Akar S, Kaplan YC, Ecemiş S, et al. The role of smoking in the development and progression of structural damage in axial SpA patients: A systematic review and meta-analysis. Eur J Rheumatol 2019; 6(4): 184-192.
  • Peters MJ, Symmons DP, McCarey D, et al. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis 2010; 69: 325-331.
  • Akkoç Y, Karatepe AG, Kirazlı Y, et al. Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index: reliability and validity. Rheumatol Int 2005; 25(4): 280-284
  • Mısırcı S, Alp A, Altan L, Yılmaz BB. Systemic ımmune ınflammation ındex in ankylosing spondylitis patients. Turk J Osteoporos 2024; 30(1): 22-29.
  • Özer HT, Sarpel T, Gulek B, et al. The Turkish version of the Bath Ankylosing Spondylitis Functional Index: reliability and validity. Clin Rheumatol 2005; 24(2): 123-128.
  • Duruöz MT, Doward L, Turan Y, et al. Translation and validation of the Turkish version of the Ankylosing Spondylitis Quality of Life (ASQOL) questionnaire. Rheumatol Int 2013; 33(11): 2717-2722.
  • Uysal MA, Kadakal F, Karşidağ C, et al. Fagerström test for nicotine dependence: reliability in a Turkish sample and factor analysis. Tuberk Toraks 2004; 52: 115-121.
  • Can-Gür G. Psychometric properties of the Turkish version: The Challenges to Stopping Smoking (CSS-21) Scale. J Subst Use 2021; 26(1): 107-113.
  • Sugiyama D, Nishimura K, Tamaki K, et al. Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 2010; 69(1): 70-81.
  • Videm V, Cortes A, Thomas R, Brown MA. Current smoking is associated with ıncident ankylosing spondylitis : The HUNT Population-based Norwegian Health Study. J Rheumatol 2014; 41(10): 2041-2048.
  • Chung HY, Machado P, van der Heijde D, et al. Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIRE cohort. Ann Rheum Dis 2012; 71(6): 809-816.
  • Villaverde-García V, Cobo-Ibáñez T, Candelas-Rodríguez G, et al. The effect of smoking on clinical and structural damage in patients with axial spondyloarthritis: A systematic literature review. Semin Arthritis Rheum 2017; 46(5): 569-583.
  • Tuğsal HY, Artin GK, Can G, et al. The impact of smoking on response to tumor necrosis factor-α inhibitor treatment in patients with ankylosing spondylitis. Turk J Med Sci 2023; 53(4): 970-978.
  • Zurita Prada PA, Urrego Laurín CL, Guillén Astete CA, et al. Influence of smoking and obesity on treatment response in patients with axial spondyloarthritis: a systematic literature review. Clin Rheumatol 2021; 40(5): 1673-1686.
  • Aykurt Karlıbel İ, Dülger S, Kasapoğlu Aksoy M, et al. Effect of cigarette smoking on sexual functions, psychological factors, and disease activity in male patients with ankylosing spondylitis, Aging Male 2019; 22(2): 109-115.
  • Naranjo A, Bilbao A, Erausquin C, et al. Results of a specific smoking cessation program for patients with arthritis in a rheumatology clinic. Rheum Int 2014; 34(1) : 93-99.
  • Stead LF, Buitrago D, Preciado N, et al. Physician advice for smoking cessation. Cochrane Database Syst Rev 2013; (5): CD000165.
  • Kaya MN, Yurumez S, Tekgöz E, et al. The role of rheumatologist in smoking cessation of ankylosing spondylitis patients: a single-center cross-sectional study. Cureus 2023; 15(9): e45461.
  • Slama K, Redman S, Perkins J, Reid AL, Sanson-Fisher RW. The effectiveness of two smoking cessation programs for use in general practice. A randomized clinical trial. BMJ 1990; 300: 1707-9.
  • Bozkurt N, Bozkurt Aİ, Erdoğan A. What is the most ımportant problem in smoking cessation? Akdeniz Medical Journal 2020; 6(3): 430-438.

Assessment of Nicotine Addiction Risk and Challenges to Stopping Smoking among Ankylosing Spondylitis Patients

Year 2025, Volume: 26 Issue: 4, 451 - 458, 30.12.2025
https://doi.org/10.51982/bagimli.1651164

Abstract

Objective: Smoking is a risk factor for rheumatic diseases. The objective of this study was to evaluate the relationship between high nicotine addiction risk and disease activity in patients with ankylosing spondylitis (AS) and the level of addiction risk and difficulty in quitting smoking.
Method: This was a cross-sectional study. A total of 65 patients diagnosed with AS were included in the study between November 2022 and September 2023. The following instruments were utilized: a patient identification form, the Bath Ankylosing Spondylitis Disease Activity Index, the Ankylosing Spondylitis Quality of Life Questionnaire, the Fagerström Nicotine Dependence Index, and the Challenges to Stopping Smoking.
Results: The results indicated that 36 patients (55.4%) exhibited moderate to severe nicotine addiction risk. The disease activity of 50 patients (77%) was found to be moderate to high, and these patients exhibited high smoking addiction risk scores and low quality of life scores. Among all patients, 42 (65%) expressed willingness to quit smoking, but this was significantly more challenging in those with moderate-high disease activity.
Conclusion: Smoking is one of the modifiable factors thought to influence disease activity in AS. Although quitting smoking is among the treatment recommendations in the treatment of AS, a significant portion of smokers (approximately two-thirds) are unable to quit smoking due to nicotine addiction, despite their desire to do so.

Ethical Statement

The study was approved by the Malatya clinical trials ethics committee (number 2022/3957).

Supporting Institution

yok

Project Number

-

Thanks

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References

  • Chen CH, Chen HA, Lu CL, et al. Association of cigarette smoking with Chinese ankylosing spondylitis patients in Taiwan: a poor disease outcome in systemic inflammation, functional ability, and physical mobility. Clin Rheumatol 2013; 32(5): 659-663.
  • Stolt P, Bengtsson C, Nordmark B, et al. EIRA study group. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population-based case-control study, using incident cases. Ann Rheum Dis 2003; 62(9): 835-841.
  • Criswell LA, Merlino LA, Cerhan JR, et al. Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study. Am J Med 2002; 112(6): 465-471.
  • Costenbader KH, Kim DJ, Peerzada J, et al. Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 2004; 50(3): 849-857.
  • Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum 2012; 64: 1388-1398.
  • Kaut IK, Abourazzak FE, Jamila E, el al. Axial spondyloarthritis and cigarette smoking. The Open Rheumatology J 2017; 11: 53-61.
  • Akar S, Kaplan YC, Ecemiş S, et al. The role of smoking in the development and progression of structural damage in axial SpA patients: A systematic review and meta-analysis. Eur J Rheumatol 2019; 6(4): 184-192.
  • Peters MJ, Symmons DP, McCarey D, et al. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis 2010; 69: 325-331.
  • Akkoç Y, Karatepe AG, Kirazlı Y, et al. Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index: reliability and validity. Rheumatol Int 2005; 25(4): 280-284
  • Mısırcı S, Alp A, Altan L, Yılmaz BB. Systemic ımmune ınflammation ındex in ankylosing spondylitis patients. Turk J Osteoporos 2024; 30(1): 22-29.
  • Özer HT, Sarpel T, Gulek B, et al. The Turkish version of the Bath Ankylosing Spondylitis Functional Index: reliability and validity. Clin Rheumatol 2005; 24(2): 123-128.
  • Duruöz MT, Doward L, Turan Y, et al. Translation and validation of the Turkish version of the Ankylosing Spondylitis Quality of Life (ASQOL) questionnaire. Rheumatol Int 2013; 33(11): 2717-2722.
  • Uysal MA, Kadakal F, Karşidağ C, et al. Fagerström test for nicotine dependence: reliability in a Turkish sample and factor analysis. Tuberk Toraks 2004; 52: 115-121.
  • Can-Gür G. Psychometric properties of the Turkish version: The Challenges to Stopping Smoking (CSS-21) Scale. J Subst Use 2021; 26(1): 107-113.
  • Sugiyama D, Nishimura K, Tamaki K, et al. Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 2010; 69(1): 70-81.
  • Videm V, Cortes A, Thomas R, Brown MA. Current smoking is associated with ıncident ankylosing spondylitis : The HUNT Population-based Norwegian Health Study. J Rheumatol 2014; 41(10): 2041-2048.
  • Chung HY, Machado P, van der Heijde D, et al. Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIRE cohort. Ann Rheum Dis 2012; 71(6): 809-816.
  • Villaverde-García V, Cobo-Ibáñez T, Candelas-Rodríguez G, et al. The effect of smoking on clinical and structural damage in patients with axial spondyloarthritis: A systematic literature review. Semin Arthritis Rheum 2017; 46(5): 569-583.
  • Tuğsal HY, Artin GK, Can G, et al. The impact of smoking on response to tumor necrosis factor-α inhibitor treatment in patients with ankylosing spondylitis. Turk J Med Sci 2023; 53(4): 970-978.
  • Zurita Prada PA, Urrego Laurín CL, Guillén Astete CA, et al. Influence of smoking and obesity on treatment response in patients with axial spondyloarthritis: a systematic literature review. Clin Rheumatol 2021; 40(5): 1673-1686.
  • Aykurt Karlıbel İ, Dülger S, Kasapoğlu Aksoy M, et al. Effect of cigarette smoking on sexual functions, psychological factors, and disease activity in male patients with ankylosing spondylitis, Aging Male 2019; 22(2): 109-115.
  • Naranjo A, Bilbao A, Erausquin C, et al. Results of a specific smoking cessation program for patients with arthritis in a rheumatology clinic. Rheum Int 2014; 34(1) : 93-99.
  • Stead LF, Buitrago D, Preciado N, et al. Physician advice for smoking cessation. Cochrane Database Syst Rev 2013; (5): CD000165.
  • Kaya MN, Yurumez S, Tekgöz E, et al. The role of rheumatologist in smoking cessation of ankylosing spondylitis patients: a single-center cross-sectional study. Cureus 2023; 15(9): e45461.
  • Slama K, Redman S, Perkins J, Reid AL, Sanson-Fisher RW. The effectiveness of two smoking cessation programs for use in general practice. A randomized clinical trial. BMJ 1990; 300: 1707-9.
  • Bozkurt N, Bozkurt Aİ, Erdoğan A. What is the most ımportant problem in smoking cessation? Akdeniz Medical Journal 2020; 6(3): 430-438.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Research
Authors

Raikan Büyükavcı 0000-0002-2234-7158

Semra Aktürk 0000-0001-9960-6851

Ümmühan Aktürk 0000-0003-2203-5223

Project Number -
Publication Date December 30, 2025
Submission Date March 4, 2025
Acceptance Date May 28, 2025
Published in Issue Year 2025 Volume: 26 Issue: 4

Cite

AMA Büyükavcı R, Aktürk S, Aktürk Ü. Assessment of Nicotine Addiction Risk and Challenges to Stopping Smoking among Ankylosing Spondylitis Patients. Bağımlılık Dergisi. December 2025;26(4):451-458. doi:10.51982/bagimli.1651164