Pistacia lentiscus L. (Sakız Ağacı)’nın Etnomedikal Kullanımları ve Fitokimyasalları

Abstract

Anacardiaceae familyasının önemli bir üyesi olan Pistacia lentiscus L. yeşil ve aromatik yaprak özelliğine sahip Akdeniz ülkelerinin sahile yakın bölgelerinde yetişen çalılık formunda bir bitkidir. Günümüze kadar yapılan birçok farmakolojik çalışmada, sakız ağacının içeriğinde bulunan metabolitlerin çok sayıda hastalığın tedavisinde (antifungal, antibakteriyal, antimikrobiyal, antienflamatuvar, anti-helicobakter pylorii aktivitesi, antiatherogenik aktivite, antitümör aktivite, yara iyileştirici aktivitesi, karaciğer koruyucu aktivite, antiproliferatif ve proapototik aktivite ve tansiyon düşürücü ve antikanser aktivite gibi) kullanıldığı rapor edilmiştir. Çalışmada, Pistacia lentiscus L.'nin reçine ve değişik bitki kısımlarından izole edilen terpenoid, flavonoid, ve fenolik ve fenolik olmayan asitler, yağ asitleri ve uçucu yağlar gibi fitokimyasalları üzerine yapılmış çalışmalar derlenmiştir. Sakız ağacının majör yağ asiti bileşenleri palmitik, linoleik ve linolenik asit, uçucu yağının majör bileşenleri ise germakren-D, trans karyofillen, δ-kardinen, limonen, α-pinen, α-mirsen olarak tespit edilmiştir. Pistacia lentiscus L.'nin majör fenolik ve fenolik olmayan asitleri malik asit, quinik asit ve tannik asit' olup majör flavonoid içerikleri ise hyperoside, luteolin, kaempferol'dır.

Keywords

• Sakız ağacı
• terpenler
• fenolik bileşenler
• yağ asitleri
• flavonoidler

Pharmacological Applications and Phytochemicals of Pistacia lentiscus L. (Lentisk Tree)

Abstract

Pistacia lentiscus L. is an important member of the family of Anacardiaceae and it is in the form of green bushes that grow in areas close to the coast of the Mediterranean countries. A large number of secondary metabolites has been reported in gum mastic trees. These metabolites were tested for many pharmacological applications . It was reported that mastic gum from lentisk has been used by traditional dealers for several medical applications in the folk medicine such as antifungal, antibacterial, antimicrobial, anti-inflammatory, anti-Helicobacter pylori activity, antiatherogenik activity, antitumor activity, wound-healing activity, liver protective activity, such as antiproliferative and proapototik activity and blood pressure-lowering and anti-cancer activity. In this study, we reviewed the phytochemicals such as terpenoids, flavonoids, phenolic and nonphenolic acids, fatty acids and essential oils extracted from resin and various plant parts of Pistacia lentiscus L. The major fatty acid components of the mastic tree were identified as palmitic, linoleic and linolenic acid, while the major components of the essential oil were germacrene-D, trans caryophyllene, δ-cardia, limonene, α-pinene and α-myrcene. Major phenolic and non-phenolic acids of Pistacia lentiscus L. were identified as malic acid, quinik acid and tannic acid. The major flavonoids of mastic gum trees were hyperoside, luteolin and kaempferol.

Keywords

• Lentisk
• terpenes
• phenolic compounds
• fatty acids
• flavonoids

References

1. Acıduman, A., İlgili, Ö. 2010. Chapters related to “geriatrics” in the canon of medicine by Avicenna. Ankara Üniversitesi Tıp Fakültesi Mecmuası 63(2):41-47.
2. Aksoy, A., Duran, N., Toroglu, S., Koksal, F., 2007. Short-term effect of mastic gum on salivary concentrations of cariogenic bacteria in orthodontic patients. Angle Orthod, 77:124–128.
3. Al-Habbal, M. J., Al-Habbal, Z., Huwez, F.U. 1984. A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin. Exp. Pharmacol. Physiol., 11:541–544.
4. Al-Said, M.S., Ageel, A.M., Parmar, N.S., Tariq, M., 1986. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J. Ethnopharmacol., 15:271–278.
5. Andrikopoulos, N.K., Kaliora, A.C., Assimopoulou, A.N., Papapeorgiou, V.P. 2003. Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother. Res., 17:501–507.
6. Assimopoulou, A.N., Zlatanos, S.N., Papageorgiou, V.P., 2005. Antioxidant activity of natural resins and bioactive triterpenes in oil substrates. Food Chem., 92:721–727.
7. Dalby, A., 2003. Food in the Ancient World. From A to Z. London: Taylor and Francis Group.
8. Dedoussis, G.V., Kaliora, A.C., Psarras, S., Chiou, A., Mylona, A., 2004. Antiatherogenic effect of Pistacia lentiscus via GSH restoration and down regulation of CD36 mRNA expression. Atherosclerosis, 174:293–303.

9. Duke, J.A., 1983. Medical Plants of the Bible. New York: Conch Publishers.
10. Giaginis, C., Theocharis, S., 2011. Current evidence on the anticancer potential of Chios mastic gum. Nutr. and Cancer, 63(8):1174-1184.
11. Grieve, M., 1994. A Modern Herbal. London: CG Leyel (Ed.).
12. Huwez, F.U., Al-Habbal, M.J., 1986. Mastic in treatment of benign gastric ulcers. Gastroenterol. Japan, 21:273–241.
13. Iauk, L., Ragusa, S., Rapisarda, A., Franco, S., Nicolosi, V.M., 1996. ‘In vitro antimicrobial activity of Pistacia lentiscus L. extracts preliminary report. J. Chemother, 8:207–209.
14. Janakat, S., Al-Merie, H., 2002. Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia, and Nicotiana glauca. J. Ethnopharmacol., 83:135–138.
15. Kaliora, A.C., Stathopoulou, M.G., Triantafillidis, J.K., Dedoussis, G.V., Andrikopoulos, N.K., 2007-a. Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic. World J Zastroenterol, 13:6031–6036.
16. Kaliora, A.C., Stathopoulou, M.G., Triantafillidis, J.K., Dedoussis, G.V., Andrikopoulos, N.K., 2007-b. Chios mastic treatment of patients with active Crohn’s disease. World J. Gastroenterol., 13:748–753.
17. Kim, H.J., Neophytou, C., 2009. Natural anti-inflammatory compounds for the management and adjuvant therapy of inflammatory bowel disease and its drug delivery system., Arch. Pharm. Res., 32:997–1004.
18. Koutsoudaki, C., Krsek, M., Rodger, A., 2005. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia. J. Agric. Food Chem., 53:7681–7685.
19. Ljubuncic, P., Song, H., Cogan, U., Azaizeh, H., Bomzon, A., 2005. The effect of aqueous extracts prepared from the leaves of Pistacia lentiscus in experimental liver disease. J. Ethnopharmacol., 100:198–204.
20. Loizou, S., Paraschos, S., Mitakou, S., Chrousos, G.P., Lekakis, I., 2009. Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells. Exp. Biol. Med. (Maywood), 234:553–561.
21. Mills, J.S., White, R., 1989. The identity of the resins from the Late Bronze Age shipwreck at Ulu Burum (Kas). Archaeometry, 31:37-44.
22. Mills, J.S., White, R., 1977. Natural resins of art and archaeology: their sources, chemistry and identification. Stud. Conserv., 22:12–31.
23. Orhan, I., Kupeli, E., Aslan, M., Kartal, M., Yesilada, E., 2006. Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. J. Ethnopharmacol., 105:235–240.
24. Özdemir, E.,2014. Sakız Ağacı. Çeşmeline. http://www.cesmeline.com/index.php/emin/120-sak-z-agac-pistacia-lentiscus; http://www.cesmeline.com/haber/?p=290 (Erişim: 20 Temmuz 2014).
25. Paraschos, S., Magiatis, P., Mitakou, S., Petraki, K., Kalliaropoulos, A., 2007. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob. Agents Chemother, 51:551–559.
26. Paula Alexandra da Silva Veiga, 2014. Pistacia lentiscus. Mastic or lentisc resin was found in residues inside Egyptian amphorae, in Serpico. Health and Medicine in Ancient Egypt: Magic and Science. https://www.academia.edu/health_and_medic ine_in_ancient_egypt_magic_and_science18 Ağustos2014
27. Said, S.A., Fernandez, C., Greff, S., Torre, F., Derridj, A., Gauquelin, T., Mevy, J.P., 2011. Inter-population variability of terpenoid composition in leaves of Pistacia lentiscus L. from Algeria: A chemo ecological approach. Molecules, 16(3):2646-2657.
28. Serpico, M., 2000. Resins, Amber and Bitumen. In: Nicholson, P.T., Shaw, I., (Eds.). Ancient Egyptian Materials and Technology, Cambridge University Press.
29. Takahashi, K., Fukazawa, M., Motohira, H., Ochiai, K., Nishikawa, H., 2003. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J. Periodontol., 74:501–505.
30. Triantafyllou, A., Chaviaras, N., Sergentanis, T.N., Protopapa, E., Tsaknis, J., 2007. Chios mastic gum modulates serum biochemical parameters in a human population. J. Ethnopharmacol., 111:43–49.
31. Süzerer, V., Onay, S., Yılmaz, M.A., Ertaş, A., Onay, A., Ersalı, Y., Tilkat, E., 2015. In vitro production of anticancer phenolic compounds from lentisk, Pistacia lentiscus L. May-June 2015, In vitro Biology Meeting of the SIVB, p:11, Tucson, Arizona, USA.
32. Włodarczyk, Z., 2007. Review of plant species cited in the Bible. Folia Horticulturae, Ann. 19(1):67-85.
33. Zhou, L., Satoh, K., Takahashi, K., Watanabe, S., Nakamura, W., 2009. Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In Vivo, 23:583–589.