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KANSER TEDAVİSİNDE GÜNCEL YAKLAŞIMLAR

Year 2016, Volume: 5 Issue: 3, 154 - 165, 31.12.2016

Abstract


Kanser, hücrelerin kontrolsüz bölünmesi ve çoğalması ile ortaya çıkan ve genetik ve çevresel koşulların etkisi altında olan kompleks bir hastalıktır. Bilinen 100’den fazla kanser türü olmasına ve belli tipteki kanserler için olabildiğince standart yaklaşımlar geliştirilmesine rağmen kanser aynı zamanda kişisel bir hastalıktır. Dünya üzerindeki hiçbir insanın DNA’sı birbirine benzemediği için kişilerin benzer tedavilere farklı cevaplar vermesi şaşırtıcı olmayan bir gerçektir. Teknolojinin ilerlemesi ile birlikte günümüzde var olan tedavilere ek olarak yeni tedavi yöntemleri geliştirilmektedir. Standart olarak kabul edilen kemoterapi, radyoterapi ve cerrahi yöntemlere ek olarak aşılar, biyolojik, hormonal, hedeflenmiş ve gen terapiler giderek artan sayıda kullanılmaya başlanmıştır. Kanser ve tedavisi hakkında bilgi edinmek isteyen bir kişinin karşısına farklı tedaviler, yaklaşımlar, bilimsel makaleler ve hurafelerden oluşan sonsuz bir kaynak denizi ortaya çıkmaktadır. Gerekli bilgiye ulaşmak için uzun ve detaylı araştırmalar yapmak gerekebilir. Bu derlemenin amacı çok basit veya çok karmaşık bilgiler arasında bir köprü oluşturmak, başarı ile uygulanan yöntemleri karşılaştırmak, günümüzde kullanılan tüm metodlar hakkında okuyucuya bilgi vermektir.


References

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CURRENT MODALITIES IN TREATMENT OF CANCER

Year 2016, Volume: 5 Issue: 3, 154 - 165, 31.12.2016

Abstract




Cancer is a complex disease emerging from uncontrolled cell proliferation and division due to various genetic and environmental factors. Even though standard procedures are applied to specific types of cancers, it is also a personal disease with more than 100 types. It is not surprising why every human being responses same to treatments as human DNA is unique. As technology progresses, new therapies including but not limited to biological, hormonal, targeted and gene therapies are developed besides current approaches such as chemotherapy, radiotherapy and surgery. One can easily get lost in a huge ocean of knowledge when he wants to learn about cancer as different types of treatments, approaches, scintific papers and superstitions are widely accesible through internet and it may take a while for the average person to reach the desired information. The aim of this review is to bridge over very simple or very complex information, compare the methods and inform the reader about modalities in cancer.


References

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  • 2. Pavlopoulou A, Spandidos DA, Michalopoulos I. Human cancer databases (review). Oncol Rep. 2015 Jan;33(1):3-18.
  • 3. Blackadar CB. Historical review of the causes of cancer. World J Clin Oncol. 2016;7(1):54-86.
  • 4. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5-29.
  • 5. Wagner SC, Ichim TE, Ma H, Szymanski J, Perez JA, Lopez J, Bogin V ve ark. Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique? J Transl Med. 2015;13:340.
  • 6. Guo C, Manjili MH, Subjeck JR, Sarkar D, Fisher PB, Wang XY. Therapeutic cancer vaccines: past, present, and future. Adv Cancer Res. 2013;119:421-75.
  • 7. Kinhikar RA, Pawar AB, Mahantshetty U, Murthy V, Dheshpande DD, Shrivastava SK. Rapid Arc, helical tomotherapy, sliding window intensity modulated radiotherapy and three dimensional conformal radiation for localized prostate cancer: a dosimetric comparison. J Cancer Res Ther. 2014 ;10(3):575-82.
  • 8. Chen H, Louie AV, Boldt RG, Rodrigues GB, Palma DA, Senan S. Quality of Life After Stereotactic Ablative Radiotherapy for Early-Stage Lung Cancer: A Systematic Review. Clin Lung Cancer. 2015 Dec 22. pii: S1525-7304(15)00303-4
  • 9. Varela G, Gómez-Hernández MT. Stereotactic ablative radiotherapy for early stage non-small cell lung cancer: a word of caution. Transl Lung Cancer Res. 2016 Feb;5(1):102-5.
  • 10. Salama JK, Gu L, Wang X, Pang HH, Bogart JA, Crawford J, Schild SE ve ark. Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE). J Thorac Oncol. 2016;11(3):361-9.
  • 11. Wan B, Lang J, Wang P, Ma CM. Treatment optimization with concurrent SBRT and intracavitary brachytherapy for locally advanced cervical cancer. J Appl Clin Med Phys. 2016;17(1):5610.
  • 12. Peters M, van der Voort van Zyp JR, Moerland MA, Hoekstra CJ, van de Pol S, Westendorp H ve ark. Development and internal validation of a multivariable prediction model for biochemical failure after whole-gland salvage iodine-125 prostate brachytherapy for recurrent prostate cancer. Brachytherapy. 2016. pii: S1538-4721(16)00013-1.
  • 13. Hendriks LE, Hermans BC, van den Beuken-van Everdingen MH, Hochstenbag MM, Dingemans AM. Effect of Bisphosphonates, Denosumab, and Radioisotopes on Bone Pain and Quality of Life in Patients with Non-Small Cell Lung Cancer and Bone Metastases: A Systematic Review. J Thorac Oncol. 2016;11(2):155-73.
  • 14. Mian M, Tinelli M, DE March E, Turri G, Meneghini V, Pescosta N, Berno T ve ark. Bortezomib, Thalidomide and Lenalidomide: Have They Really Changed the Outcome of Multiple Myeloma? Anticancer Res. 2016;36(3):1059-65.
  • 15. Yang IA, Shaw JG, Goddard JR, Clarke M, Reid DW. Use of inhaled corticosteroids in COPD: improving efficacy. Expert Rev Respir Med. 2016; 10(3):339-50.
  • 16. Lee CH, Hyun MK, Jang EJ, Lee NR, Kim K, Yim JJ. Inhaled corticosteroid use and risks of lung cancer and laryngeal cancer. Respir Med. 2013;107(8):1222-33.
  • 17. Patil Y, Amitay Y, Ohana P, Shmeeda H, Gabizon A. Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity. J Control Release. 2016;225:87-95.
  • 18. Michalska M, Schultze-Seemann S, Bogatyreva L, Hauschke D, Wetterauer U, Wolf P. In vitro and in vivo effects of a recombinant anti-PSMA immunotoxin in combination with docetaxel against prostate cancer. Oncotarget. 2016 Mar 9. doi: 10.18632/oncotarget.8001.
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  • 22. Lucena SR, Salazar N, Gracia-Cazaña T, Zamarrón A, González S, Juarranz Á, Gşlaberte Y ve ark. Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer. Int J Mol Sci. 2015;16(10):25912-33.
  • 23. Takahashi K, Yamanaka S. Induced pluripotent stem cells in medicine and biology. Development. 2013;140(12):2457-61.
  • 24. Jung YW, Hysolli E, Kim KY, Tanaka Y, Park IH. Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies. Curr Opin Neurol. 2012;25(2):125-30
  • 25. Cho DY, Lin SZ, Yang WK, Lee HC, Hsu DM, Lin HL, Chen CC ve ark. Targeting cancer stem cells for treatment of glioblastoma multiforme. Cell Transplant. 2013;22(4):731-9.
  • 26. Takeuchi A, Eto M, Tatsugami K, Yamada H, Yokomizo A, Shiota M, Itsumi M ve ark. Renal cancer treatment with recipient lymphocyte infusion enhanced the antitumor effect of nonmyeloablative allogeneic stem cell transplantation. Transpl Immunol. 2015;32(2):131-9.
  • 27. Beitinjaneh A, Saliba RM, Medeiros LJ, Turturro F, Rondon G, Korbling M, Fayad L ve ark. Comparison of survival in patients with T cell lymphoma after autologous and allogeneic stem cell transplantation as a frontline strategy or in relapsed disease. Biol Blood Marrow Transplant. 2015;21(5):855-9.
  • 28. Kundu N, Ma X, Kochel T, Goloubeva O, Staats P, Thompson K, Martin S ve ark. Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res Treat. 2014;143(1):19-31.
  • 29. Ali S, Mondal N, Choudhry H, Rasool M, Pushparaj PN, Khan MA, Mahfooz M ve ark. Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players. Front Oncol. 2016;6:45.
  • 30. Sakai M, Elhilali M, Papadopoulos V. The GnRH Antagonist Degarelix Directly Inhibits Benign Prostate Hyperplasia Cell Growth. Horm Metab Res. 2015;47(12):925-31
  • 31. Groom AG, Younis T. Endocrine therapy for breast cancer prevention in high-risk women: clinical and economic considerations. Expert Rev Pharmacoecon Outcomes Res. 2016 Mar 17:1-11.
  • 32. Li F, Dou J, Wei L, Li S, Liu J. The selective estrogen receptor modulators in breast cancer prevention. Cancer Chemother Pharmacol. 2016 Jan 20. [Epub ahead of print]
  • 33. Chlebowski RT, Manson JE, Anderson GL, Cauley JA, Aragaki AK, Stefanick ML, Lane DS ve ark. Estrogen plus progestin and breast cancer incidence and mortality in the Women's Health Initiative Observational Study. J Natl Cancer Inst. 2013;105(8):526-35.
  • 34. Ohlmann CH. Chemotherapy of prostate cancer. Urologe A. 2015; 54(10):1461-9.
  • 35. Grover NS, Park SI. Novel Targeted Agents in Hodgkin and Non-Hodgkin Lymphoma Therapy. Pharmaceuticals (Basel). 2015 Sep 17;8(3):607-36.
  • 36. Müller P, Kreuzaler M, Khan T, Thommen DS, Martin K, Glatz K, Savic S ve ark. Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade. Sci Transl Med. 2015;7(315):315ra188.
  • 37. Luo TY, Cheng PC, Chiang PF, Chuang TW, Yeh CH, Lin WJ. 188Re-HYNIC-trastuzumab enhances the effect of apoptosis induced by trastuzumab in HER2-overexpressing breast cancer cells. Ann Nucl Med. 2015;29(1):52-62.
  • 38. Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY ve ark. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012;367(19):1783-91.
  • 39. Illés Á, Jóna Á, Miltényi Z. Brentuximab vedotin for treating Hodgkin's lymphoma: an analysis of pharmacology and clinical efficacy. Expert Opin Drug Metab Toxicol. 2015;2:1-9.
  • 40. Rael E, Rakszawski K, Koller K, Bayerl M, Butte M, Zheng H. Treatment with rituximab and brentuximab vedotin in a patient of common variable immune deficiency-associated classic Hodgkin lymphoma. Biomark Res. 2016;4:7.
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Details

Primary Language Turkish
Journal Section Derlemeler
Authors

Onur Baykara

Publication Date December 31, 2016
Submission Date May 2, 2016
Published in Issue Year 2016 Volume: 5 Issue: 3

Cite

APA Baykara, O. (2016). KANSER TEDAVİSİNDE GÜNCEL YAKLAŞIMLAR. Balıkesir Sağlık Bilimleri Dergisi, 5(3), 154-165.

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