The Effect of Anesthesia Induction with Midazolam and Propofol on Hemodynamics in Abdominal Hysterectomy Surgeries

Year 2024, Volume: 13 Issue: 2, 354 - 359, 28.08.2024

Serkan Uçkun , Emine Nur Tozan

https://doi.org/10.53424/balikesirsbd.1406575

Abstract

Objective: The primary task of anesthesiology is to control the patient's hemodynamic values, including blood pressure and heart rate, from pre-operative to post-operative. Many drugs are used alone or in combination for induction and maintenance of anesthesia. Various hemodynamic responses may develop to these drugs. In our study, we aimed to compare the effects of midazolam and propofol used alone in intravenous anesthesia induction on hemodynamics in patients undergoing abdominal hysterectomy. Materials and Methods: A total of 60 ASA I-II patients scheduled for abdominal hysterectomy were included in the study. During anesthesia induction, midazolam (0.2 mg/kg) was administered to Group M (n:30) and propofol 1% (2 mg/kg) was administered to Group P (n:30). Noninvasive systolic blood pressure, diastolic blood pressure, mean blood pressure and minute heart rate values were recorded. Results: Systolic blood pressure was significantly lower in group P than in M during intubation, skin incision, extubation and recovery. Conclusion:As a result, anesthesia induction with intravenous 0.2 mg/kg midazolam may cause higher systolic blood pressure values than 2 mg/kg propofol. It should not be overlooked that the hemodynamic response that will occur after the use of midazolam during anesthesia monitoring will vary depending on the anesthetic drugs and doses used together.

Keywords

General anesthesia, midazolam, hemodynamic

Abdominal Histerektomi Ameliyatlarında Midazolam ile Anestezi İndüksiyonunun Hemodinami Üzerine Etkisi

Abstract

Amaç: Anesteziyolojinin birincil görevi, ameliyat öncesinden ameliyat sonrasına kadar hastanın kan basıncı ve kalp atış hızı dahil olmak üzere hemodinamik değerlerini kontrol etmektir. Anestezi indüksiyonu ve idamesi için birçok ilaç tek başına veya kombinasyon halinde kullanılır. Bu ilaçlara karşı çeşitli hemodinamik yanıtlar gelişebilmektedir. Çalışmamızda abdominal histerektomi yapılan hastalarda intravenöz anestezi indüksiyonunda tek başına kullanılan midazolam ve propofolün hemodinami üzerine etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Abdominal histerektomi planlanan toplam 60 ASA I-II hasta çalışmaya dahil edildi. Anestezi indüksiyonu sırasında Grup M'ye (n:30) midazolam (0.2 mg/kg) ve Grup P'ye (n:30) propofol %1 (2 mg/kg) uygulandı. Noninvaziv sistolik kan basıncı, diyastolik kan basıncı, ortalama kan basıncı ve dakika kalp atım hızı değerleri kaydedildi. Bulgular: Entübasyon, cilt insizyonu, ekstübasyon ve derlenme sırasında sistolik kan basıncı P grubunda M grubuna göre anlamlı olarak daha düşüktü. Sonuç: İntravenöz 0,2 mg/kg midazolam ile anestezi indüksiyonu 2 mg/kg propofolden daha yüksek sistolik kan basıncı değerlerine neden olabilir. Anestezi takibi sırasında midazolam kullanımı sonrası oluşacak hemodinamik yanıtın birlikte kullanılan anestezik ilaçlara ve dozlarına bağlı olarak değişeceği göz ardı edilmemelidir.

Keywords

Genel anestezi, midazolam, hemodinami

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