Antimicrobial activities of different extracts from Centaurea iberica

Derya Doğanay; Esra Mertoğlu; Bahar Gürdal; Gizem Gülsoy Toplan

doi:10.53445/batd.1840067

EN TR

Antimicrobial activities of different extracts from Centaurea iberica

Abstract

Across different regions of the world, plants have long been valued for their wide range of functional properties. Aromatic plants, in particular, are cultivated to obtain natural compounds used in cosmetic scenting, food enhancement, and preservation. Within this category, species belonging to the Asteraceae family have gained increasing attention in recent years due to their expanding relevance in numerous applied disciplines. The objective of this study was to evaluate the antibacterial and antifungal potential of different solvent extracts (n-hexane, ethyl acetate, and methanol) and an infusion of Centaurea iberica L. against five bacterial (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumannii ATCC 19606, Pseudomonas aeruginosa ATCC 27853) and two yeast (Candida albicans ATCC 10231 and Candida parapsilosis ATCC 22019) strains using the microdilution method. The minimum inhibitory concentration (MIC) values for all tested microorganisms ranged between 78.125 and 5000 µg/mL. According to the results, all studied extracts exhibited stronger antifungal activity than antibacterial activity. Among them, the ethyl acetate extract demonstrated the most potent antifungal effect with MIC values between 78.125 and 156.25 µg/mL, whereas the infusion extract showed the weakest overall activity. In conclusion, further phytochemical investigations are required to identify the secondary metabolites responsible for these activities, which may contribute to the development of novel antifungal agents.

Keywords

Antibacterial, antifungal, Centaurea, Asteraceae

Centaurea iberica bitkisinden elde edilen farklı ekstrelerin antimikrobiyal aktiviteleri

Abstract

Bitkiler dünyanın farklı bölgelerinde, geniş işlevsel özellikleri nedeniyle uzun zamandır değer görmektedir. Özellikle aromatik bitkiler, kozmetik ürünlerde koku verici olarak, gıdalarda lezzet artırıcı ve koruyucu doğal bileşiklerin elde edilmesi amacıyla yetiştirilmektedir. Bu kategoride yer alan Asteraceae familyasına ait türler, çeşitli uygulamalı disiplinlerde artan önemleri nedeniyle son yıllarda giderek daha fazla ilgi görmektedir. Bu çalışmanın amacı, Centaurea iberica L. bitkisinin farklı çözücü ekstrelerinin (n-heksan, etil asetat ve metanol) ve infüzyonunun beş bakteri (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumannii ATCC 19606, Pseudomonas aeruginosa ATCC 27853) ve iki maya (Candida albicans ATCC 10231 ve Candida parapsilosis ATCC 22019) suşuna karşı mikrodilüsyon yöntemi kullanılarak antibakteriyel ve antifungal potansiyelinin değerlendirilmesidir. Tüm test mikroorganizmaları için minimum inhibitör konsantrasyon (MİK) değerleri 78,125-5000 µg/mL aralığında değişmiştir. Elde edilen bulgulara göre, incelenen tüm ekstreler antibakteriyel aktiviteye kıyasla daha güçlü antifungal aktivite göstermiştir. Tüm ekstreler arasında etil asetat ekstresi, 78,125-156,25 µg/mL aralığındaki MİK değerleriyle en güçlü antifungal aktiviteyi sergilerken, genel olarak en zayıf aktivite infüzyon ekstresinde görülmüştür. Sonuç olarak, bu biyolojik aktivitelerden sorumlu ikincil metabolitleri tanımlayabilmek için daha ileri fitokimyasal araştırmalara ihtiyaç duyulmakta olup, bu bileşikler yeni antifungal ajanların geliştirilmesine katkı sağlayabilir.

Keywords

Antibakteriyel, antifungal, Centaurea, Asteraceae

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Details

Primary Language

English

Subjects

Plant Biochemistry

Journal Section

Research Article

Authors

Derya Doğanay
0000-0001-9147-4110
Türkiye

Esra Mertoğlu
0009-0005-5759-0958
Türkiye

Bahar Gürdal
0000-0003-4009-100X
Türkiye

Gizem Gülsoy Toplan ^*
0000-0002-0544-2532
Türkiye

Publication Date

December 30, 2025

Submission Date

December 11, 2025

Acceptance Date

December 28, 2025

Published in Issue

Year 2025 Volume: 6 Number: 3

DOI

https://doi.org/10.53445/batd.1840067

IZ

https://izlik.org/JA63DH77MY

APA

Doğanay, D., Mertoğlu, E., Gürdal, B., & Gülsoy Toplan, G. (2025). Antimicrobial activities of different extracts from Centaurea iberica. Journal of Integrative and Anatolian Medicine, 6(3), 186-195. https://doi.org/10.53445/batd.1840067

AMA

1.Doğanay D, Mertoğlu E, Gürdal B, Gülsoy Toplan G. Antimicrobial activities of different extracts from Centaurea iberica. J. Integr. Anatol. Med. 2025;6(3):186-195. doi:10.53445/batd.1840067

Chicago

Doğanay, Derya, Esra Mertoğlu, Bahar Gürdal, and Gizem Gülsoy Toplan. 2025. “Antimicrobial Activities of Different Extracts from Centaurea Iberica”. Journal of Integrative and Anatolian Medicine 6 (3): 186-95. https://doi.org/10.53445/batd.1840067.

EndNote

Doğanay D, Mertoğlu E, Gürdal B, Gülsoy Toplan G (December 1, 2025) Antimicrobial activities of different extracts from Centaurea iberica. Journal of Integrative and Anatolian Medicine 6 3 186–195.

IEEE

[1]D. Doğanay, E. Mertoğlu, B. Gürdal, and G. Gülsoy Toplan, “Antimicrobial activities of different extracts from Centaurea iberica”, J. Integr. Anatol. Med., vol. 6, no. 3, pp. 186–195, Dec. 2025, doi: 10.53445/batd.1840067.

ISNAD

Doğanay, Derya - Mertoğlu, Esra - Gürdal, Bahar - Gülsoy Toplan, Gizem. “Antimicrobial Activities of Different Extracts from Centaurea Iberica”. Journal of Integrative and Anatolian Medicine 6/3 (December 1, 2025): 186-195. https://doi.org/10.53445/batd.1840067.

JAMA

1.Doğanay D, Mertoğlu E, Gürdal B, Gülsoy Toplan G. Antimicrobial activities of different extracts from Centaurea iberica. J. Integr. Anatol. Med. 2025;6:186–195.

MLA

Doğanay, Derya, et al. “Antimicrobial Activities of Different Extracts from Centaurea Iberica”. Journal of Integrative and Anatolian Medicine, vol. 6, no. 3, Dec. 2025, pp. 186-95, doi:10.53445/batd.1840067.

Vancouver

1.Derya Doğanay, Esra Mertoğlu, Bahar Gürdal, Gizem Gülsoy Toplan. Antimicrobial activities of different extracts from Centaurea iberica. J. Integr. Anatol. Med. 2025 Dec. 1;6(3):186-95. doi:10.53445/batd.1840067

J. Integr. Anatol. Med. (Abbreviated Title)

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e-ISSN: 2687-6345

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This work is licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).

Antimicrobial activities of different extracts from Centaurea iberica

Abstract

Keywords

Centaurea iberica bitkisinden elde edilen farklı ekstrelerin antimikrobiyal aktiviteleri

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

J. Integr. Anatol. Med. (Abbreviated Title)