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Year 2001, Volume: 3 Issue: 1, 148 - 174, 01.06.2001

Rivhard G. Brereton Conrad Bessant

Abstract

Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry

Year 2001, Volume: 3 Issue: 1, 148 - 174, 01.06.2001

Rivhard G. Brereton Conrad Bessant

Abstract

It is now common to obtain information from two or more detectors in HPLC simultaneously. Conventionally both DAD-HPLC and LC-MS data are obtained independently, often using quite different approaches, but there will be common features in both types of information. However, these will be distorted, for example, Electrospray MS profiles are typically more noisy and tailing compared to those from DAD-HPLC due to the different physical processes of passing from the chromatographic column to the detector. A method for obtaining and processing both types of data simultaneously is described. The analysis of isomers with identical molecular weights and similar elution times is particularly important in the pharmaceutical industry where small impurities can have a major influence on biological activity. The approach is illustrated by application to a mixture of 2- and 3-hydroxypyridine at varying levels of overlap

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Other ID JA22DV68SY
Authors

Rivhard G. Brereton This is me

Conrad Bessant This is me

Submission Date June 1, 2001
Publication Date June 1, 2001
Published in Issue Year 2001 Volume: 3 Issue: 1

Cite

APA Brereton, R. G., & Bessant, C. (2001). Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 3(1), 148-174.
AMA Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi. June 2001;3(1):148-174.
Chicago Brereton, Rivhard G., and Conrad Bessant. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3, no. 1 (June 2001): 148-74.
EndNote Brereton RG, Bessant C (June 1, 2001) Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3 1 148–174.
IEEE R. G. Brereton and C. Bessant, “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”, Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 3, no. 1, pp. 148–174, 2001.
ISNAD Brereton, Rivhard G. - Bessant, Conrad. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3/1 (June2001), 148-174.
JAMA Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2001;3:148–174.
MLA Brereton, Rivhard G. and Conrad Bessant. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 3, no. 1, 2001, pp. 148-74.
Vancouver Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2001;3(1):148-74.