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Year 2002, Volume: 4 Issue: 2, 17 - 19, 01.12.2002

A. Pappa Louisi P. Agrafiotou G. Zissopoulou P. Liatsi

Abstract

Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography

Year 2002, Volume: 4 Issue: 2, 17 - 19, 01.12.2002

A. Pappa Louisi P. Agrafiotou G. Zissopoulou P. Liatsi

Abstract

The reversed-phase (RP) chromatographic behaviour of the macrolide antibiotics clarithromycin (Clari) and roxithromycin (Roxi) was extensively studied as a function of mobile phase composition - modified with one, two or three of organic solvents - and column temperature. The results of our study provide a satisfactory thermodynamic explanation for the retention processes of these macrolides in RP-HPLC and give additional information on the selection of optimal separation conditions for the determination of Clari in human plasma using Roxi as an internal standard and vice versa

Keywords

clarithromycin roxithromycin HPLC retention

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Details

Other ID JA22DT68TM
Journal Section Research Articles
Authors

A. Pappa Louisi This is me

P. Agrafiotou This is me

G. Zissopoulou This is me

P. Liatsi This is me

Publication Date December 1, 2002
Submission Date December 1, 2002
Published in Issue Year 2002 Volume: 4 Issue: 2

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APA Pappa Louisi, A., Agrafiotou, P., Zissopoulou, G., Liatsi, P. (2002). Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 4(2), 17-19.
AMA Pappa Louisi A, Agrafiotou P, Zissopoulou G, Liatsi P. Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography. BAUN Fen. Bil. Enst. Dergisi. December 2002;4(2):17-19.
Chicago Pappa Louisi, A., P. Agrafiotou, G. Zissopoulou, and P. Liatsi. “Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-Phase Liquid  Chromatography”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 4, no. 2 (December 2002): 17-19.
EndNote Pappa Louisi A, Agrafiotou P, Zissopoulou G, Liatsi P (December 1, 2002) Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 4 2 17–19.
IEEE A. Pappa Louisi, P. Agrafiotou, G. Zissopoulou, and P. Liatsi, “Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography”, BAUN Fen. Bil. Enst. Dergisi, vol. 4, no. 2, pp. 17–19, 2002.
ISNAD Pappa Louisi, A. et al. “Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-Phase Liquid  Chromatography”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 4/2 (December 2002), 17-19.
JAMA Pappa Louisi A, Agrafiotou P, Zissopoulou G, Liatsi P. Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography. BAUN Fen. Bil. Enst. Dergisi. 2002;4:17–19.
MLA Pappa Louisi, A. et al. “Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-Phase Liquid  Chromatography”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 4, no. 2, 2002, pp. 17-19.
Vancouver Pappa Louisi A, Agrafiotou P, Zissopoulou G, Liatsi P. Influence of Temperature and Mobile Phase Composition on Retention Properties of the Macroline Antibiotics Clarithromicin and Roxithromcin  in Reversed-phase Liquid  Chromatography. BAUN Fen. Bil. Enst. Dergisi. 2002;4(2):17-9.