BibTex RIS Kaynak Göster

Yıl 2001, Cilt: 3 Sayı: 1, 148 - 174, 01.06.2001

Rivhard G. Brereton Conrad Bessant

Öz

Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry

Yıl 2001, Cilt: 3 Sayı: 1, 148 - 174, 01.06.2001

Rivhard G. Brereton Conrad Bessant

Öz

It is now common to obtain information from two or more detectors in HPLC simultaneously. Conventionally both DAD-HPLC and LC-MS data are obtained independently, often using quite different approaches, but there will be common features in both types of information. However, these will be distorted, for example, Electrospray MS profiles are typically more noisy and tailing compared to those from DAD-HPLC due to the different physical processes of passing from the chromatographic column to the detector. A method for obtaining and processing both types of data simultaneously is described. The analysis of isomers with identical molecular weights and similar elution times is particularly important in the pharmaceutical industry where small impurities can have a major influence on biological activity. The approach is illustrated by application to a mixture of 2- and 3-hydroxypyridine at varying levels of overlap

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Ayrıntılar

Diğer ID JA22DV68SY
Bölüm Araştırma Makalesi
Yazarlar

Rivhard G. Brereton Bu kişi benim

Conrad Bessant Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2001
Gönderilme Tarihi 1 Haziran 2001
Yayımlandığı Sayı Yıl 2001 Cilt: 3 Sayı: 1

Kaynak Göster

APA Brereton, R. G., & Bessant, C. (2001). Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 3(1), 148-174.
AMA Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. BAUN Fen. Bil. Enst. Dergisi. Haziran 2001;3(1):148-174.
Chicago Brereton, Rivhard G., ve Conrad Bessant. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3, sy. 1 (Haziran 2001): 148-74.
EndNote Brereton RG, Bessant C (01 Haziran 2001) Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3 1 148–174.
IEEE R. G. Brereton ve C. Bessant, “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”, BAUN Fen. Bil. Enst. Dergisi, c. 3, sy. 1, ss. 148–174, 2001.
ISNAD Brereton, Rivhard G. - Bessant, Conrad. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 3/1 (Haziran 2001), 148-174.
JAMA Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. BAUN Fen. Bil. Enst. Dergisi. 2001;3:148–174.
MLA Brereton, Rivhard G. ve Conrad Bessant. “Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry”. Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 3, sy. 1, 2001, ss. 148-74.
Vancouver Brereton RG, Bessant C. Simultaneous Resolution of Overlapping Tailing Peaks of Isomers Using Dual Detector Diode Array Liquid Chromatography Electrospray Mass Spectrometry. BAUN Fen. Bil. Enst. Dergisi. 2001;3(1):148-74.