Ghrelin ve Egzersiz İlişkisi

Year 2019, Volume: 3 Issue: 2, 40 - 50, 26.12.2019

Şükran Arıkan

Abstract

Enerji homeostazı ve
vücut ağırlığının düzenlenmesi, sinirsel ve hormonal kontrollerle elde edilen enerji
alımı ve harcaması arasındaki karmaşık dengeye dayanır. Egzersizin genel
sağlığı, iştah kontrolü, insülin duyarlılığı, obezite, tip II diyabet, kanser
ve hipertansiyon gibi kronik hastalıkları korumada ve önlenmesinde birçok
yararı bilinmektedir. Fakat egzersizin bu etkilerine aracılık eden moleküler
mekanizmalar tam olarak anlaşılamamıştır. İştah ve enerji alımının
düzenlenmesinde çok sayıda hormon görev almaktadır. Egzersizin besin alımı ve
iştah üzerindeki etkileri son yıllarda araştırıcıların ilgisini çekmiştir.  Enerji düzenlenmesinde görev aldığı düşünülen
ghrelin hormonunun keşfi ile bu konu üzerindeki çalışmalar hız kazanmıştır.
Ghrelin, yeme davranışı ve kilo dengesini düzenleyen insanlarda iştahı artırdığı
saptanan 28 aminoasitten oluşan peptid yapısında bir hormondur. Bu derlemenin
amacı literatürde yapılan çalışmalar ışığında ghrelin hormununun yapısı, etki
mekanizması, diğer hormonlarla ve egzersizle ilişkisi hakkında güncel bilgileri
biraraya getirerek bundan sonra yapılacak araştırmalara yol göstermektir.

Keywords

ghrelin, iştah, egzersiz

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