Streptozosin İndüklü Deneysel Diyabet Modelinde Poliherbal Karışımın Hematoprotektif Etkileri

Year 2024, , 353 - 363, 27.08.2024

İsa Kıran , İlknur Kulcanay Şahin , Mustafa Cengiz , Canan Vejselova Sezer , Rıfat Ertekin , Suzan Onur , Namık Bilici , Adnan Ayhancı

https://doi.org/10.58605/bingolsaglik.1506656

Abstract

Bu çalışmada streptozotosin ile indüklenen diyabetik sıçanlarda Curcuma longa, Nigella sativa, Prunus mahaleb ve Vitis vinifera çekirdeğinden oluşan poliherbal ekstraktının ve metforminin; periferik kan, kemik iliği ve antioksidan parametreler üzerine etkisi araştırıldı. 60 adet wistar cinsi albino sıçanlar; kontrol, STZ, STZ + MET, STZ + PH I (500 mg/kg) ve STZ + PH II (1000 mg/kg) şeklinde 5 gruba ayrıldı. Hemoglobin, hematokrit, eritrosit, lökosit ve trombosit değerlerinde, STZ’de kontrol’e kıyasla yaklaşık %12-20 azalma, tedavi gruplarında STZ’ye kıyasla artış görüldü. Poliherbal bileşimin metformin grubuna kıyasla artış eğilimi yüksek bulundu. Kemik iliği, kontrol ve STZ grubu ile karşılaştırıldığında STZ’de azalma, tedavi gruplarında ise artış gösterdi. Poliherbal bileşimin metformin grubuna kıyasla artış eğilimi yüksek olarak değerlendirildi. Süperoksit dismutaz, katalaz ve nonenzimatik antioksidan glutatyon, kontrol ve STZ grubu karşılaştırıldığında STZ’de azalma, tedavi gruplarında STZ’ye kıyasla artış görüldü. Poliherbal bileşimin metformin grubuna kıyasla artış eğilimi yüksek saptandı. Malondialdehit, kontrol ve STZ ile karşılaştırıldığında STZ grubunda artış saptandı. Metformin ile STZ grubu arasında değişme görülmedi ancak poliherbal gruplarda STZ’ye kıyasla azalma eğilimi görüldü.
Hematolojik veriler, kemik iliği ve antioksidan değerlerin poliherbal fomülasyonlar ile değişim gösterdiği saptandı. Sonuçlar, metformin ile kıyaslandığında poliherbal bileşiklerin iyileşme potansiyeli olabileceğini göstermektedir.

Keywords

Diyabet, Poiherbal karışım, Metformin, Streptozotosin, Antioksidan, Hematoprotektif etki

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