Ratlarda 7, 12-DMBA ile oluşturulan kanser modelinde α-lipoik asit ve resveratrol’un etkileri

Abstract

α-Lipoik asit LA diyabetik polinöropati ve hepatik hasarları kapsayan çeşitli hastalıklarda terapatik ajan olarak yoğun olarak araştırılmıştır. Bununla birlikte LA ve indirgenmiş formu olan dihidrolipoik asit DHLA kanserin, kimyasal yollardan önlenmesi üzerine etkileri rapor edilmiştir. Bu çalışmada DHLA/LA’in 7,12-dimetilbenzentrasen tarafından oluşturulan kanser modeline etkileri araştırılmıştır. Diğer bir terapatik ajan olan resveratrol, antioksidan ve antimutajen olarak dut, üzüm, fıstık, çam ve şarapta yüksek konsatrasyonlarda bulunmuştur. Bunlara ek olarak LA ve resveratrol, ratlarda oluşturulan kanser modelinde kanserojen tedavide preneoplastik lezyonların gelişimini inhibe etmiştir. Bu çalışmada elde edilen veriler, resveratrol ve α-lipoik asitin insanların beslenmelerinde yaygın bir bileşen ve insanlarda kanserin kimyasal olarak önlenmesinde potansiyel bir ajan olduğunu göstermiştir

Keywords

• α-Lipoik asit,resveratrol,DMBA,yağ asitleri,vitaminler

Effects of ?-lipoic acid and resveratrol on rats cancer model induced by 7, 12-DMBA

Abstract

α-Lipoic acid LA has been intensely investigated as a therapeutic agent for several diseases, including hepatic disorder and diabetic polyneuropathy. However, the effects of LA or its reduced form, dihydrolipoic acid DHLA , on cancer chemoprevention has been slightly reported. In the present study, we examined the effects of DHLA/LA on rat cancer model induced by 7,12-dimethylbenz a anthracene DMBA . Another therapeutic agent; Resveratrol, was found in high concentrations in berry, grape, peanut, pine and wine and act as an antioxidant and antimutagen. In addition, resveratrol and α-lipoic acid inhibited the development of preneoplastic lesions in carcinogen-treated rat cancer model. Datas in this study suggest that resveratrol and α-Lipoic acid, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans

Keywords

• α-Lipoic acid,resveratrol,DMBA,fatty acids,vitamins

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