Sphingolipids are structural molecules of cellular membranes, that regulate biological processes such growth, proliferation, migration, metastasis by controlling signaling functions of cancer cells. Recent research in cancer therapy has sought to find mechanical details of tumor growth and roles of sphingolipids and their downstream targets in chemotherapy, radiotherapy and/or immunotherapy responses, by innovative molecular and pharmacological tools targeting sphingolipid signaling nodes in cancer cells.
Lung cancer is one of the most common cancers in our country and in the world. An important part of cancer-derived deaths is lung cancer-derived. New and effective treatment modalities for lung cancer are increasingly needed.
This research investigated the novel and effective treatment approach by inhibiting the formation of ceramidase-1-phosphate, which inhibits apoptosis, with synthesis of solid lipid nanoparticles of the ceramidase inhibitor-ARN14974=BOC, thereby increasing the intracellular level of cell and promoting cell viability and proliferation.
Results showed, cytotoxicity, antiproliferative effect, morphological and ultrastructural changes indicating apoptosis caused by ARN14974=BOC and its nanoparticle formulation on A549 cells. Apoptosis was induced by the agents via raising ROS, causing cell cycle arrest. The results underlined and prooved that cell death is trigered more effectively by the nanoparticle formulation of ARN14974=BOC on human non-small cell lung cancer cells.
1901S014
Sfingolipidler hücre membran yapısında bulunan ve kanser hücresinde sinyalleşme işlevlerini kontrol ederek büyüme, proliferasyon, göç, metastaz gibi biyolojik fonksiyonları düzenlemekte olan moleküllerdir. Kanser tedavisinde son yıllardaki araştırmalar, kanser hücrelerindeki sfingolipid sinyalleşmesini hedef alan, yenilikçi moleküler ve farmakolojik araçlar kullanılarak tümör büyümesinin ve kemoterapi, radyoterapi ve/veya immünoterapiye yanıtta sfingolipidlerin ve alt hedeflerinin rolü hakkında mekanik ayrıntılar bulmayı amaçlamıştır.
Akciğer kanseri ülkemizde ve dünyada en sık görülen kanser türlerindendir. Kanser kaynaklı ölümlerin önemli bir kısmı akciğer kanserine bağlıdır. Akciğer kanseri için yeni ve etkili tedavi yöntemlerinin geliştirilmesine her gün daha çok ihtiyaç duyulmaktadır.
Bu çalışmada, ARN14974=BOC seramidaz inhibitörünün katı lipit nanopartikül formunun sentezlenmesi ile seramidin hücre içi seviyesini arttırarak hücrenin yaşamını ve proliferasyonunu sağlayan ve apoptozu inhibe eden seramidaz-1-fosfatın oluşumunu engelleyerek yeni ve etkili bir tedavi yaklaşımının küçük hücreli dışı akciğer kanseri hücre hattı A549 hücrelerinde araştırılması amaçlanmıştır.
Çalışma sonuçları ARN14974=BOC’un ve nanopartikül formunun A549 hücrelerinde sitotoksik ve antiproliferatif etkileri tespit edilmiş ve bu hücrelerde apoptozu gösteren morfolojik ve ince yapısal değişiklikler saptanmıştır. Bu moleküllerin A549 hücrelerinde reaktif oksijen türlerinin artması ve hücre döngüsünün durdurulmasına neden olarak apoptozu tetiklemiştir. Bu sonuçlar, insan küçük hücreli dışı akciğer kanseri hücrelerinde hücre ölümünün sentezlenen ARN14974=BOC’un nanopartikül formu tarafından daha etkin bir biçimde gerçekleştirildiğini göstermiştir.
Anadolu Üniversitesi BAP
1901S014
Bu çalışma Anadolu Üniversitesi Bilimsel Araştırma Projeleri Kapsamında 1901S014 proje numarası ile desteklenmiştir.
Primary Language | Turkish |
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Subjects | Cell Development, Proliferation and Death, Traditional, Complementary and Integrative Medicine (Other) |
Journal Section | Research Articles |
Authors | |
Project Number | 1901S014 |
Early Pub Date | January 18, 2024 |
Publication Date | April 15, 2024 |
Submission Date | August 24, 2023 |
Acceptance Date | October 7, 2023 |
Published in Issue | Year 2024 Volume: 17 Issue: 1 |
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❖ Correspondance Adres: Prof. Ersin YÜCEL, Sazova Mahallesi, Ziraat Caddesi, No.277 F Blok, 26005 Tepebaşı-Eskişehir/Türkiye
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❖ Biological Diversity and Conservation/ Biyolojik Çeşitlilik ve Koruma
❖ ISSN 1308-5301 Print; ISSN 1308-8084 Online
❖ Start Date Published 2008
❖ © Copyright by Biological Diversity and Conservation/Biyolojik Çeşitlilik ve Koruma-Available online at www.biodicon.com/All rights reserved
❖ Publisher : ERSİN YÜCEL (https://www.ersinyucel.com.tr/)
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❖ Editör / Editor-In-Chief : Prof.Dr. Ersin YÜCEL, https://orcid.org/0000-0001-8274-7578