Re-visiting lactate dehydrogenase from a different dimension: a model bioinformatics study for wrestling

Year 2023, , 17 - 23, 30.06.2023

Levent Cavas Onder Daglioglu Bülent Cavas

https://doi.org/10.38042/biotechstudies.1276399

Abstract

Sports bioinformatics is of great importance in the understanding of sports performance from different perspectives. Accumulated bio-sequences in databases provide considerable contributions to compare proteins in different organisms. In Kingdom of Animalia, some animals have experienced evolution for excellent athletic performances in nature. The present paper exhibits a model in silico approach for the evaluation of sports performance by comparing lactate dehydrogenases (LDH) in humans (Homo sapiens) and saltwater crocodiles (Crocodylus porosus). The results show that a high sequence similarity is observed between the LDHs from H. sapiens and C. porosus with minor modifications. The stability and grand averages of hydrophobicity index values for studied LDHs were found as 24.79–25.18 and -0.006 –0.020 in H. sapiens and C. porosus, respectively. In conclusion, the identification of amino acid modifications in important enzymes of specific animals that are related to sports physiology are lessons we learn from from nature, which can open a new gate for the development of sports performance and talent selection.

Keywords

Athletic Performance, Bioinformatics, Sport Bioinformatics, Lactate Dehydrogenase, Amino Acids

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