Development of PLGA wound dressing containing silver nanoparticles synthesized from licorice extract

Abstract

Nanofiber wound dressings are developed using various polymers and adding different active agents to the polymers during the production phase. In this study, PLGA, PLGA containing silver nanoparticles (AgNP/PLGA), PLGA nanofibers containing 1%, 2%, 3% licorice root, and silver nanoparticle doped (LR-AgNP/PLGA) were produced by electrospinning method. The green synthesis method was used to produce licorice-containing silver nanoparticles (LR-AgNP). The morphological analysis of nanofibers was determined using diameter measurements on SEM images. The average fiber diameters of PLGA, AgNP/PLGA, and LR-AgNP/PLGA nanofibers are 344 nm, 260 nm, and 357 nm, respectively. FTIR analysis was used for the determination of chemical bonds. The FTIR graph of PLGA, AgNP/PLGA and LR-AgNP/PLGA nanofibers showed similar peaks in the 3008-2883 cm-1, 1500-1412 cm-1, 1181-1086 cm-1 and 1755-1750 cm-1 bands. The wound healing potential of the produced nanofibers was evaluated on an in vitro wound scratch model. According to the results obtained, LR-AgNP/PLGA nanofibers showed the fastest wound closure. As a result of these studies, it was determined that PLGA nanofibers with silver nanoparticles containing licorice root extract could accelerate the wound healing process.

Keywords

• Electrospinning
• Wound healing
• Nanofibers
• Silver nanoparticle doped PLGA

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