Platin ve Bakır Temelli N-Heterosiklik Karben (NHC) Komplekslerinin Antikanser Özellikleri ve Etki Mekanizmaları

Year 2019, Volume: 8 Issue: 2, 713 - 724, 28.06.2019

Aydın Aktaş

https://doi.org/10.17798/bitlisfen.480144

https://izlik.org/JA77YL58ZH

Abstract

Metal-N-Heterosiklik Karben (M-NHC) kompleksleri
uzun yıllardır organometalik kimyada katalitik aktivite gösteren bileşikler
olarak ön plana çıkmaktadırlar. Son yıllarda bu bileşiklerin biyolojik
özelliklerini ön plana çıkaran çalışmalar yoğun ilgi görmektedir. Kanser
çağımızın önemli bir hastalığı olup tedavisinde kullanılacak ilaçların keşfi
oldukça önemlidir. Bu nedenle M-NHC komplekslerinin antikanser özellikleri ile
ilgili çalışmalar önem kazanmıştır. Antikanser etki gösteren platin ve bakır
temelli M-NHC kompleksleri, bu komplekslerin en önemli olanlarındandır. NHC’lere
bağlı bulunan sübstitüentlerin değiştirilmesi ile M-NHC komplekslerinin antikanser
aktiviteleride değişmektedir. Bu bileşiklerin antikanser etki mekanizmaları DNA
mutasyonları ve Reaktif Oksijen Türleri (ROT)‘nden oluşur. Bununla beraber
M-NHC komplekslerinin antikanser etki mekanizmalarını tam olarak ortaya koyacak
ve yeni sentezlenecek komplekslere yol gösterecek çalışmalara ihtiyaç vardır.

Keywords

N-heterosiklik karben , Metal-NHC kompleksleri , Antikanser ajan , DNA mutasyonu , Reaktif oksijen türleri

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