Platin ve Bakır Temelli N-Heterosiklik Karben (NHC) Komplekslerinin Antikanser Özellikleri ve Etki Mekanizmaları

Abstract

Metal-N-Heterosiklik Karben (M-NHC) kompleksleri uzun yıllardır organometalik kimyada katalitik aktivite gösteren bileşikler olarak ön plana çıkmaktadırlar. Son yıllarda bu bileşiklerin biyolojik özelliklerini ön plana çıkaran çalışmalar yoğun ilgi görmektedir. Kanser çağımızın önemli bir hastalığı olup tedavisinde kullanılacak ilaçların keşfi oldukça önemlidir. Bu nedenle M-NHC komplekslerinin antikanser özellikleri ile ilgili çalışmalar önem kazanmıştır. Antikanser etki gösteren platin ve bakır temelli M-NHC kompleksleri, bu komplekslerin en önemli olanlarındandır. NHC’lere bağlı bulunan sübstitüentlerin değiştirilmesi ile M-NHC komplekslerinin antikanser aktiviteleride değişmektedir. Bu bileşiklerin antikanser etki mekanizmaları DNA mutasyonları ve Reaktif Oksijen Türleri (ROT)‘nden oluşur. Bununla beraber M-NHC komplekslerinin antikanser etki mekanizmalarını tam olarak ortaya koyacak ve yeni sentezlenecek komplekslere yol gösterecek çalışmalara ihtiyaç vardır.

Keywords

• N-heterosiklik karben,Metal-NHC kompleksleri,Antikanser ajan,DNA mutasyonu,Reaktif oksijen türleri

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