Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Gökçe Ceren Boya; Fatma Gökçe Apaydın

EN

Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Abstract

Fenamiphos is a broad-spectrum organophosphate insecticide. It is used in agriculture to control soil nematodes in several cops like peanuts, tomatoes, ginger, as well as in pineapples, cotton in worldwide. Naringenin is one of the flavonoids and was found to display strong anti-inflammatory and antioxidant effect. In this study, we investigated how naringenin had protective effects on the damaged rat heart tissue caused by fenamiphos. In the study, experimental rats were organized into four equal groups. These; control, naringenin, fenamiphos and fenamiphos plus naringenin. The chemicals were given to the rats by orally during for 28 days. After 4th week, malondialdehyde (MDA) levels and antioxidant enzyme activities (SOD, CAT, GPx and GST) in rat heart tissues were investigated spectrophotometrically by various methods. Also, histopathological changes were analysed by light microscope. Any important changes were observed between control and naringenin treated groups. End of the experimental timeline, fenamiphos caused increasing the levels of MDA while a decrease in antioxidant enzyme activities were detected in comparison with the control animals. In addition, many pathological changes were observed in fenamiphos treated group. Fewer pathological changes and less oxidative damage were detected in the group in which fenamiphos and naringenin were administered together. In the study it is observed that fenamiphos caused oxidative stress and histopathological changes in rat heart tissue, naringenin treatment reduced this toxicity.

Keywords

Fenamiphos, Naringenin, Heart, Oxidative stress, Histopathology

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Details

Primary Language

English

Subjects

Animal Physiology-Ecophysiology

Journal Section

Research Article

Authors

Gökçe Ceren Boya
0009-0006-5035-0596
Türkiye

Fatma Gökçe Apaydın ^*
0000-0002-2771-7488
Türkiye

Publication Date

November 30, 2023

Submission Date

August 21, 2023

Acceptance Date

September 25, 2023

Published in Issue

Year 2023 Volume: 1 Number: 2

IZ

https://izlik.org/JA93GZ22RU

APA

Boya, G. C., & Apaydın, F. G. (2023). Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. Bozok Journal of Science, 1(2), 73-80. https://izlik.org/JA93GZ22RU

AMA

1.Boya GC, Apaydın FG. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS. 2023;1(2):73-80. https://izlik.org/JA93GZ22RU

Chicago

Boya, Gökçe Ceren, and Fatma Gökçe Apaydın. 2023. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science 1 (2): 73-80. https://izlik.org/JA93GZ22RU.

EndNote

Boya GC, Apaydın FG (November 1, 2023) Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. Bozok Journal of Science 1 2 73–80.

IEEE

[1]G. C. Boya and F. G. Apaydın, “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”, BJS, vol. 1, no. 2, pp. 73–80, Nov. 2023, [Online]. Available: https://izlik.org/JA93GZ22RU

ISNAD

Boya, Gökçe Ceren - Apaydın, Fatma Gökçe. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science 1/2 (November 1, 2023): 73-80. https://izlik.org/JA93GZ22RU.

JAMA

1.Boya GC, Apaydın FG. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS. 2023;1:73–80.

MLA

Boya, Gökçe Ceren, and Fatma Gökçe Apaydın. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science, vol. 1, no. 2, Nov. 2023, pp. 73-80, https://izlik.org/JA93GZ22RU.

Vancouver

1.Gökçe Ceren Boya, Fatma Gökçe Apaydın. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS [Internet]. 2023 Nov. 1;1(2):73-80. Available from: https://izlik.org/JA93GZ22RU

Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Abstract

Keywords

Abstract

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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