Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Gökçe Ceren Boya; Fatma Gökçe Apaydın

EN

Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Öz

Fenamiphos is a broad-spectrum organophosphate insecticide. It is used in agriculture to control soil nematodes in several cops like peanuts, tomatoes, ginger, as well as in pineapples, cotton in worldwide. Naringenin is one of the flavonoids and was found to display strong anti-inflammatory and antioxidant effect. In this study, we investigated how naringenin had protective effects on the damaged rat heart tissue caused by fenamiphos. In the study, experimental rats were organized into four equal groups. These; control, naringenin, fenamiphos and fenamiphos plus naringenin. The chemicals were given to the rats by orally during for 28 days. After 4th week, malondialdehyde (MDA) levels and antioxidant enzyme activities (SOD, CAT, GPx and GST) in rat heart tissues were investigated spectrophotometrically by various methods. Also, histopathological changes were analysed by light microscope. Any important changes were observed between control and naringenin treated groups. End of the experimental timeline, fenamiphos caused increasing the levels of MDA while a decrease in antioxidant enzyme activities were detected in comparison with the control animals. In addition, many pathological changes were observed in fenamiphos treated group. Fewer pathological changes and less oxidative damage were detected in the group in which fenamiphos and naringenin were administered together. In the study it is observed that fenamiphos caused oxidative stress and histopathological changes in rat heart tissue, naringenin treatment reduced this toxicity.

Anahtar Kelimeler

Fenamiphos, Naringenin, Heart, Oxidative stress, Histopathology

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Hayvan Fizyolojisi - Ekofizyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Gökçe Ceren Boya
0009-0006-5035-0596
Türkiye

Fatma Gökçe Apaydın ^*
0000-0002-2771-7488
Türkiye

Yayımlanma Tarihi

30 Kasım 2023

Gönderilme Tarihi

21 Ağustos 2023

Kabul Tarihi

25 Eylül 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 1 Sayı: 2

IZ

https://izlik.org/JA93GZ22RU

APA

Boya, G. C., & Apaydın, F. G. (2023). Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. Bozok Journal of Science, 1(2), 73-80. https://izlik.org/JA93GZ22RU

AMA

1.Boya GC, Apaydın FG. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS. 2023;1(2):73-80. https://izlik.org/JA93GZ22RU

Chicago

Boya, Gökçe Ceren, ve Fatma Gökçe Apaydın. 2023. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science 1 (2): 73-80. https://izlik.org/JA93GZ22RU.

EndNote

Boya GC, Apaydın FG (01 Kasım 2023) Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. Bozok Journal of Science 1 2 73–80.

IEEE

[1]G. C. Boya ve F. G. Apaydın, “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”, BJS, c. 1, sy 2, ss. 73–80, Kas. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA93GZ22RU

ISNAD

Boya, Gökçe Ceren - Apaydın, Fatma Gökçe. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science 1/2 (01 Kasım 2023): 73-80. https://izlik.org/JA93GZ22RU.

JAMA

1.Boya GC, Apaydın FG. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS. 2023;1:73–80.

MLA

Boya, Gökçe Ceren, ve Fatma Gökçe Apaydın. “Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats”. Bozok Journal of Science, c. 1, sy 2, Kasım 2023, ss. 73-80, https://izlik.org/JA93GZ22RU.

Vancouver

1.Gökçe Ceren Boya, Fatma Gökçe Apaydın. Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats. BJS [Internet]. 01 Kasım 2023;1(2):73-80. Erişim adresi: https://izlik.org/JA93GZ22RU

Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Öz

Anahtar Kelimeler

Öz

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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